What drugs block serotonin receptors?
Answers from top 10 papers
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| Papers (10) | Insight |
|---|---|
25 Citations | Drugs which selectively block the reuptake of serotonin are effective antidepressants with a low incidence of side effects. |
| This experiment supports the hypothesis that pipamperone, even in the low-dose range, significantly blocks serotonin-2A receptors. | |
| We found that widely used antiinflammatory drugs antagonize both biochemical and behavioral responses to selective serotonin reuptake inhibitors (SSRIs). | |
845 Citations | We describe a new class of drugs that selectively block serotonin M-receptors on peripheral neurones. |
97 Citations | Drugs blocking serotonin 5-HT2A or 5-HT2C receptors should be preferred over those whose sedative property is caused by histamine receptor blockade only. |
61 Citations | Furthermore, modification of serotonin receptor sensitivity is probably not relevant to the mode of action of antidepressant drugs. |
16 Citations | The similar affinities of non‐amines and conventional antidepressant drugs for the SERT support the view that an amine nitrogen is not essential for drugs to block serotonin transport with high affinity. |
10 Citations | The results suggest that all three antidepressants block muricide in part through their effects on serotonin. |
80 Citations | Ultimately, we propose that novel antidepressant drugs that selectively target these serotonin receptors could be developed to yield improvements over current treatments for major depressive disorders. |
Open access•Journal Article 33 Citations | Drugs that are even more specific in that they act on specific serotonin receptor subtypes, rather than only by blocking serotonin uptake, may provide efficacy and fewer side effects for patients who do not respond to or tolerate less specific agents. |
Related Questions
How do SSRIs work on serotonin receptors?5 answersSSRIs exert their therapeutic effects by inhibiting the serotonin transporter (SERT) and increasing extracellular serotonin levels. However, recent research suggests that the mechanism of action of SSRIs on serotonin receptors is more complex. Studies indicate that SSRIs can stimulate the 5-HT2B receptor, which is crucial for their antidepressant effects, and this stimulation is independent of SERT inhibition. Additionally, there is evidence of interactions between 5-HT receptors and key proteins in serotonin metabolism, contributing to the delay in therapeutic effects and treatment resistance to SSRIs. Furthermore, SSRIs may modulate other neurotransmitter systems, such as neuronal nicotinic acetylcholine receptors, impacting mood regulation and potentially influencing depression symptoms. These findings highlight the multifaceted ways in which SSRIs interact with serotonin receptors to produce their antidepressant effects.
What are the effects of serotonin levels on mood?5 answersSerotonin levels have been found to have an impact on mood. Low serotonin levels can lead to changes in mood, disrupt sleep patterns, and contribute to depression. On the other hand, increasing serotonin levels in the brain can enhance communication between brain cells, resulting in an uplifted mood and reduced depression symptoms. Studies have shown that low serotonin can contribute to lowered mood, but cannot cause lowered mood by itself. Other unknown systems may interact with serotonin to lower mood. Increased serotonin levels have been associated with decreased quarrelsomeness and increased agreeableness, which can lead to better mood and social interactions. Serotonin also plays a role in modulating emotional processing, attention, and recognition of positive and negative emotional material. Overall, serotonin levels have a significant impact on mood and can influence various aspects of emotional well-being.
What are the different types of drugs that act on serotonin receptors?4 answersThere are several types of drugs that act on serotonin receptors. Conventional serotonin-enhancing antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), increase synaptic neurotransmission of serotonin through stimulation and blockade of various subtypes of 5-HT receptors. Serotoninergic hallucinogens, such as lysergic acid diethylamide (LSD), dimethyltryptamine (DMT), and psilocybin, agonistically act on 5-HT2A receptors, leading to increased glutamatergic transmission and neuroplasticity. Additionally, there are selective ligands and drugs that target specific 5-HT receptor subtypes, such as lorcaserin and pimavanserin, which target the 5-HT2C and 5-HT2A receptors, respectively, and provide new treatments for obesity and Parkinson's disease psychosis. Serotonin receptor ligands, including aripiprazole, ziprasidone, risperidone, olanzapine, mianserin, and quetiapine, are used for the treatment of central nervous system-related disorders. These drugs and ligands interact with different serotonin receptor subtypes to modulate serotonin neurotransmission and have therapeutic effects on various neuropsychiatric disorders.
What substances or supplements increases serotonin in hippocampus?3 answersSubstances or supplements that increase serotonin in the hippocampus include the K+ channel blocker quinine, the 5-HT1/2/6 receptor antagonist methiothepin, and substance P. Additionally, the novel dopamine D3-preferring D3/D2 and serotonin 5-HT1A receptor partial agonist cariprazine has been shown to have activity in increasing serotonin in the hippocampus.
How does paroxetine interact with serotonin in PTSD?2 answersParoxetine, a selective serotonin reuptake inhibitor (SSRI), interacts with serotonin in the context of post-traumatic stress disorder (PTSD). Clinical studies have shown that SSRI treatment with paroxetine can induce remission of PTSD symptoms and increase prefrontal activation. The role of serotonin in PTSD has been explored through animal model studies and clinical investigations, including neuroimaging and pharmacologic challenges. Serotonin dysregulation has been implicated in PTSD, with symptoms such as aggression, impulsivity, depression, and suicidality being associated with serotonergic dysfunction. In the treatment of panic disorder, paroxetine has been found to be more effective in patients with specific allelic variations in the serotonin transporter gene. Overall, paroxetine's interaction with serotonin in PTSD involves its ability to modulate serotonin levels and receptor activity, leading to symptom remission and improved treatment outcomes.
What drug selectively kills serotonin neurons?4 answers