scispace - formally typeset
Search or ask a question

Answers from top 10 papers

More filters
Papers (10)Insight
Our results showed that graphene is a novel class of material promising for biological applications including future in vivo cancer treatment with various aromatic, low-solubility drugs.
The above results suggest that the functionalized graphene-based material has potential applications for targeted delivery and controlled release of anticancer drugs.
Considering that the combined use of two or more drugs, a widely adopted clinical practice, often displays much better therapeutic efficacy than that of a single drug, the controlled loading and targeted delivery of mixed anticancer drugs using these graphene-based nanocarriers may find widespread application in biomedicine.
Graphene based nanomaterials as an anticancer therapeutics can be applied in photothermal therapy, as a drug carrier but also as nano-drugs by themselves.
Moreover, graphene-modified composites are promising candidates to deliver growth factors, drugs and others bioactive compounds.
Here graphene plays the dual role of a versatile substrate for temporary storage of drugs and an effective transducer of NIR-light into heat.
When combined with anticancer drugs, graphene and its derivatives have been reported to increase the efficacy of the drug simultaneously reducing its side effects.
The loading and delivery of anticancer drugs using this kind of graphene-based nanocarrier may find potential application in biomedicine.
The proposed approach has the advantage of green production of an applicable graphene-based drug delivery system for improving the smart transportation of hydrophobic anti-cancer drugs.
Therefore, thiolated graphene represents a promising platform for oral delivery of hydrophobic drugs, possessing a long residence time on intestinal mucosa which allows the release of the loaded drug close to the adsorptive epithelium.

See what other people are reading

What are the applications of Mg alloys in implants?
4 answers
Magnesium (Mg) alloys are promising materials for biodegradable temporary implants due to their biodegradability, biocompatibility, and mechanical properties. However, their rapid corrosion rates in physiological environments hinder their widespread use. To address this, various coating methodologies have been explored, such as hydroxyapatite (HA) coatings and hybrid coatings with synthetic and natural polymers. These coatings enhance corrosion resistance, biocompatibility, and mechanical integrity of Mg alloys, making them suitable for biomedical applications. Surface modifications like plasma electrolytic oxidation (PEO) have also been successful in reducing corrosion rates and improving biological properties of Mg implants, promoting cell proliferation and extracellular matrix formation. Overall, the applications of Mg alloys in implants benefit from these coating and modification strategies to overcome corrosion challenges and enhance functionality.
What are the potential benefits of using hyaluronic acid supplements for joint health?
4 answers
Hyaluronic acid (HA) supplements offer various benefits for joint health. They can help restore the rheological properties of synovial fluid, reduce inflammation, alleviate pain, and improve joint function. HA supplements can also preserve viscoelasticity, reduce friction in joints, and expedite functional recovery post-arthroscopic surgery. High molecular weight HA, like GreenIuronic®, can promote tissue regeneration, maintain joint homeostasis, and prevent cartilage degradation in osteoarthritis. Studies have shown that intra-articular HA injections significantly improve symptoms in knee osteoarthritis patients, with effects peaking around 8-12 weeks post-administration. Combining HA with other substances like cyclodextrin and vitamin E can enhance viscoelastic and lubrication properties, provide antioxidant benefits, and improve clinical outcomes. Overall, HA supplements offer a promising approach for managing joint diseases effectively.
Why nitrigen doped graohene is better that graphene for gas sensing?
5 answers
Nitrogen-doped graphene exhibits enhanced gas-sensing capabilities compared to pristine graphene due to several key factors. Firstly, the introduction of nitrogen into the graphene lattice induces a band gap, which is absent in pristine graphene, thereby improving its electrical conductivity and sensitivity to gas molecules. This modification allows for a more pronounced modulation of electrical conductivity in response to gas adsorption, making nitrogen-doped graphene a superior material for detecting various gases. The doping process also generates defects and increases the surface area, which maximizes the interaction between the surface and gas molecules, further enhancing the gas-sensing performance. Density Functional Theory (DFT) studies have shown that nitrogen-doped graphene sheets exhibit selective binding to different gases, such as carbon monoxide, carbon dioxide, and oxygen, which is crucial for the development of selective gas sensors. The electronic structures of these doped graphene sheets are altered in a way that improves their ability to detect specific gases. Additionally, the presence of nitrogen creates special binding sites that are beneficial for near-surface interaction with gas molecules, significantly changing the electronic characteristics of graphene and its derivatives and expanding its potential use as gas sensors. Experimental research has demonstrated that nitrogen-doped graphene sensors are responsive to low concentrations of gases at room temperature, showcasing higher sensitivity and excellent reproducibility compared to their undoped counterparts. Furthermore, the introduction of nitrogen into graphene has been shown to facilitate stronger chemisorption of gas molecules, such as NO2, leading to higher sensitivity and selectivity towards these gases. The codoping of heteroatoms, including nitrogen, in graphene has been explored to further improve gas sensing properties, indicating that nitrogen doping is a key strategy in enhancing the performance of graphene-based gas sensors. In summary, nitrogen doping enhances the gas-sensing capabilities of graphene by introducing a band gap, generating defects, increasing surface area, and creating specific binding sites for gas molecules, which collectively contribute to improved sensitivity, selectivity, and overall performance of gas sensors.
What are the potential risks and complications associated with using composite restorations for amalgam restoration repair?
5 answers
Composite restorations used for repairing failed amalgam restorations pose risks and complications. Composite restorations have a higher failure rate due to recurrent decay compared to amalgam restorations. The inability of composites to seal discrepancies at the restoration-tooth interface leads to recurrent decay, necessitating larger replacements that can ultimately result in tooth loss. Additionally, composite resin restorations are associated with a higher risk of mucosal lesions, while no significant association was found between amalgam restorations and mucosal lesions. Therefore, when considering repair options for failed amalgam restorations, the increased risk of recurrent decay and potential mucosal lesions associated with composite restorations should be carefully evaluated.
Does a commercial absorbent diapers have high water retention? '?
4 answers
Commercial absorbent diapers typically have high water retention capabilities due to the presence of water-absorbing agents with specific physical properties. These agents, such as polyacrylic acid salt-based water-absorbing resins, particulate water absorbing agents with specific characteristics, and water-absorbent resins with high liquid-retention capacity under load, contribute to the overall water retention of the diaper. Additionally, the synthesis of high-retention water absorbents from materials like kraft pulp can further enhance water retention in diapers. The combination of these materials in the diaper structure ensures efficient absorption and retention of liquid, making commercial absorbent diapers effective in managing moisture.
What are the specific properties of PVA and sodium alginate for wound healing?
5 answers
Sodium alginate (SA) and polyvinyl alcohol (PVA) are polymers known for their wound healing properties. SA/PVA films exhibit enhanced physical, mechanical, and biological characteristics compared to individual polymers. These films can be crosslinked with Ca2+ to further improve their physicochemical and biological properties. Incorporating bioactive substances like collagen and hyaluronic acid into PVA-based hydrogel membranes enhances wound healing efficacy. Additionally, SA/PVA scaffolds blended with Moringa oleifera extract show high biocompatibility and excellent wound healing capacity, with higher extract content leading to better outcomes. Furthermore, PVA/Alginate mats containing Arnebia Euchroma extract demonstrate antimicrobial properties and promote wound closure through collagen synthesis and skin remodeling. These properties make SA and PVA promising materials for advanced wound dressings.
What are the current advancements in the development of piezoresistive pressure sensors based on poly-silicon?
5 answers
Current advancements in piezoresistive pressure sensors based on poly-silicon include the utilization of silicon nanowires (SiNWs) for enhanced sensing capabilities. SiNWs exhibit unique one-dimensional electronic structures, making them ideal for various applications such as biosensors, FETs, and piezoresistive pressure sensors. Additionally, the development of flexible piezoresistive membranes using polymer solutions has shown promising results, with increased sensitivity and gauge factors for piezoresistive sensing applications. Furthermore, the integration of ultra-thin graphene foam (GRF) with polydimethylsiloxane (PDMS) in piezoresistive pressure sensors has demonstrated sensitivity to pressures ranging from 0 to >100kPa, although not yet comparable to current sensors. These advancements highlight the diverse approaches being explored to enhance the performance and applications of poly-silicon-based piezoresistive pressure sensors.
Does oxidation of liposomal solutions influence the temperatur stability ?
4 answers
Oxidation of liposomal solutions can indeed influence temperature stability. Liposomes are sensitive to oxidation, which can lead to changes in their stability and behavior. Lipid peroxidation caused by reactive oxygen species can damage membranes and liposomal dispersions. Additionally, the oxidative stability of phosphatidylcholines (PCs) in liposomes is influenced by the positional distribution of polyunsaturated fatty acids (PUFAs) in the PC molecule. Moreover, the presence of antioxidants can help prevent oxidation and improve the stability of liposomes. Therefore, when liposomal solutions undergo oxidation, it can impact their temperature stability due to changes in the lipid structure and integrity, potentially affecting their performance as drug delivery systems.
How does chemical vapor growth of graphene work?
5 answers
Chemical vapor deposition (CVD) for graphene growth involves complex gas-phase surface reactions, mass, momentum, and energy transfer processes. Factors like temperature, pressure, and reactor design play crucial roles in optimizing graphene synthesis. Electric fields applied during CVD can significantly impact graphene growth, enabling selective or rapid growth of clean films. Direct CVD of graphene on specific substrates like 3C-SiC can be challenging due to low carbon atom diffusion, necessitating alternative methods like PECVD for successful growth. A modified CVD method utilizing ceramic plates and defect-rich vertical graphene accelerates graphene growth without increasing nucleation density, enabling rapid millimeter-sized graphene grain production in minutes. Overall, CVD processes involve intricate mechanisms combining chemical reactions, transport phenomena, and reactor optimization to achieve efficient graphene synthesis.
Solid state foaming process PCL possible?
4 answers
The solid-state foaming process of Poly(e-caprolactone) (PCL) is indeed feasible and has been extensively studied in various research papers. Studies have shown that utilizing supercritical carbon dioxide (scCO2) as a physical blowing agent enables the successful foaming of PCL. The incorporation of other materials such as Poly (lactic-co-glycolic acid) (PLGA), hydroxyapatite, nanocellulose, carboxymethylcellulose, and graphene oxide has been explored to enhance the properties of the foamed PCL structures. Optimal process parameters have been identified, including pressure, temperature, and time, to achieve structures suitable for biomedical applications. The biocompatibility of the resulting PCL foams has been confirmed, making them suitable for use in artificial scaffolds for cell culture in biomedical engineering.
Solid state foaming process pure PCL possible?
5 answers
Yes, the solid-state foaming process of pure poly(e-caprolactone) (PCL) is feasible. Research has shown that PCL can be foamed using supercritical carbon dioxide (scCO2) as a physical blowing agent, resulting in porous structures with controllable properties. Additionally, studies have explored the use of non-toxic and environmentally friendly blowing agents, such as supercritical mixtures of carbon dioxide (CO2) and ethyl lactate (EL), to foam PCL at relatively low temperatures. Furthermore, investigations into the foaming behavior of PCL with nitrogen as the foaming agent have provided insights into the correlation between foam structure and processing variables, aiding in the design of PCL foams with desired properties. Therefore, the solid-state foaming of pure PCL is not only possible but can also be tailored to achieve specific characteristics for various applications.