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Here, we further demonstrate that such glia-to-neuron conversion can rebalance neuron-glia ratio and reverse glial scar back to neural tissue.
This drug may be able to reduce the detrimental effects to the neuron during postischemic recirculation and may thus help the neuron to survive during this critical period.
This study leads us to introduce a new neuron mode...
Somatic voltage clamp also helps to partially correct for the apparent depression, but a good model of the neuron can do even better in providing a more accurate view of the underlying synaptic conductances.

Related Questions

Why do nerve cells pump out sodium ions instead of potassium to keep a resting potential?5 answersNerve cells pump out sodium ions instead of potassium to maintain the resting potential due to the specific functions of the Na+-K+ ATPase pump and the membrane permeability for each ion. The Na+-K+ ATPase pump, located in the plasma membrane, actively transports 3 Na+ out and 2 K+ into the cell for every ATP consumed, contributing to the establishment and maintenance of the resting membrane potential. This process is essential for stabilizing the cell's resting potential, regulating cell volume, and facilitating cell signaling. The asymmetric distribution of sodium and potassium ions across the membrane, along with the selective permeability of the membrane to these ions, plays a crucial role in establishing the resting potential of nerve cells.
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In mouse what characterizes layer 5 pyramidal prefrontal cortex neurons?
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N2A cells, when transfected with tau plasmids, show a downregulation of mRNA levels of several Kv channels, including Kv2.1, Kv3.1, Kv4.1, Kv9.2, and KCNH4, and a reduction in macroscopic currents through Kv channels, indicating an impact on electrical activity. On the other hand, NT2 neurons (NT2Ns) derived from stem cells exhibit sodium-dependent action potentials and responses to depolarization and neurotransmitters, showcasing their ability to generate action potentials. Additionally, exposure to 17β-estradiol inhibits Kv currents in N2A cells in a concentration-dependent manner, affecting peak and steady-state currents through Kv channels, suggesting a modulation of electrical activity. Therefore, while N2A cells can exhibit changes in Kv channel activity under certain conditions, stem cell-derived neurons like NT2Ns are capable of firing action potentials.