scispace - formally typeset
Search or ask a question

What is IPSC? 

Best insight from top research papers

Induced pluripotent stem cells (iPSCs) are a powerful modeling system for medical discovery and translational research. iPSCs can be generated from any person and have the potential to differentiate into various cell types, making them a promising resource for regenerative medicine and personalized cell therapy-based strategies . iPSCs have been used as disease models for drug screening and development, particularly in the field of neurology for understanding and treating neurodegenerative diseases . They have also been utilized in cancer immunotherapies, specifically in the generation of natural killer (NK) cells, which can be modified to exert a desired response to tumor cells . Overall, iPSCs offer a versatile and valuable tool in studying disease mechanisms, drug mechanisms, and cell therapies, with potential applications in various fields of medicine.

Answers from top 3 papers

More filters
Papers (3)Insight
The paper does not provide a direct answer to the query. The paper is about long non-coding RNAs in induced pluripotent stem cells and their differentiation.
The paper does not provide a direct answer to the query. The paper discusses the use of induced Pluripotent Stem Cells (iPSCs) as a disease model for drug development in neurological disorders.
IPSC stands for induced pluripotent stem cells.

Related Questions

What is spss?5 answersSPSS, which stands for Statistical Package for the Social Sciences, is a software used for statistical analysis, data management, and data documentation. It is a popular software package used in various fields such as health sciences, marketing, and tourism management and marketing. SPSS provides capabilities for data preparation, data import, parametric and nonparametric statistical tests, export and editing of statistical results, and creation of charts and tables. It is known for its user-friendly interface and compatibility with popular software like Microsoft Office. SPSS is widely used in Indonesia, even by individuals with limited knowledge of statistics and computers. The software is specifically designed for statistical analysis and the information provided in this book refers to version for Windows.
How did IPSC come to be?5 answersInduced pluripotent stem cells (iPSCs) were derived from various sources, including human somatic cells and embryonic stem cells (ESCs). The iPSC technology provided a breakthrough in the field of regenerative medicine by allowing the generation of patient-specific cells for disease modeling and drug discovery. The process of iPSC derivation involves reprogramming somatic cells using factors such as Oct3/4, Sox2, Klf4, and c-Myc. Different methods, such as viral delivery or episomal reprogramming, have been used to generate iPSCs. The resulting iPSCs exhibit pluripotency and can differentiate into various cell types representing the three germ layers. iPSCs have the potential to become a valuable source material for cell-based therapies and personalized medicine. They offer opportunities for disease modeling, drug testing, and the development of new therapies for neurodegenerative disorders and other diseases.
How can ipsc cells be used to help patients?5 answersInduced pluripotent stem cells (iPSCs) can be used to help patients in several ways. Firstly, iPSCs can be reprogrammed from adult somatic cells and used to develop personalized cell-based therapies for various human diseases. This offers the potential for permanent corrective therapies for currently incurable disorders. Secondly, iPSCs can be differentiated into specific cell types, such as cardiomyocytes, providing a platform for studying cardiovascular diseases and drug-induced cardiotoxicity. This enables the investigation of disease mechanisms and the development of personalized precision medicine. Thirdly, iPSCs can be programmed into neurons, particularly glial cells, to better understand neurodegenerative diseases like Alzheimer's and Parkinson's disease. This allows for more accurate disease modeling and the potential for developing disease-modifying therapies. Lastly, iPSCs can be used as models for studying genetic mutations and for high-throughput drug screenings, aiding in the development and testing of gene therapies for neuromuscular and motor neuron disorders.
How can ipsc cells help kidney disease?3 answersInduced pluripotent stem cells (iPSCs) have the potential to help in the treatment of kidney disease. iPSCs can be reprogrammed from adult somatic cells and have the ability to differentiate into any cell type in the body, including kidney cells. This makes them a promising tool for disease modeling and drug discovery, as well as for developing personalized cell-based therapies for currently incurable kidney disorders. Studies have shown that iPSC-derived extracellular vesicles (EVs) can support renal recovery after injury, reducing cell death and inflammatory response, protecting functional mitochondria, and regulating genes associated with oxidative stress. iPSCs can also be used to generate nephron progenitor cells (NPCs) and reconstruct kidney organoids in vitro, which can be used for cell therapies against kidney diseases like acute kidney injury (AKI). However, further research is needed to fully understand iPSC differentiation and to address challenges related to safety, efficacy, and integration as autograft therapies.
What is IP?0 answersIP refers to intellectual property, which encompasses various forms of intangible assets such as patents, copyrights, trademarks, and trade secrets. It is a term used to describe the legal protection that allows the rightsholder to exclude others from interfering with or using their property rights in specified ways. IP has become increasingly important in business practice, as it is integrated into organizations' overall business models and innovation activities. IP protection strategies need to consider factors such as the subject matter, timeframe of protection, and total expense. IP departments play a crucial role in weighing these considerations and performing essential IP protection functions. In the context of communication, IP is the basic method used by over a billion people through the public Internet. It provides a connectionless, unreliable, best efforts packet delivery system.
What does IPS stand for in supply chain?10 answers

See what other people are reading

What is hm4di function?
3 answers
The hM4Di receptor is a chemogenetic DREADD (designer receptor exclusively activated by designer drugs) system that is used to suppress neuronal activities. Activation of the hM4Di receptor reduces membrane excitability, which is thought to be mediated by the opening of GIRK channels. Previous studies have suggested that GIRK channels are barely expressed in the striatum, raising the question of whether the hM4Di receptor activation-induced reduction in membrane excitability in striatal medium spiny neurons (MSNs) is truly mediated by endogenous GIRK channels. However, recent research using a GIRK channel-selective blocker, tertiapin-Q (TPNQ), has shown that TPNQ-sensitive GIRK channels, although expressed at low levels, are likely the major mediator downstream of hM4Di receptor activation to reduce membrane excitability in striatal MSNs.
Does ID4 play a role in cancer progression?
5 answers
ID4 plays a role in cancer progression. It is enriched in LGR5-high colon cancer stem cells and its high expression is associated with poor pathological differentiation and shorter survival in colorectal cancer patients. In pancreatic cancer, ID4 is upregulated and its expression is closely associated with TNM stage and low survival rates. In breast cancer, ID4 is associated with a stem-like phenotype and poor prognosis, and it enhances angiogenesis by increasing the expression of pro-angiogenic cytokines. In myeloid malignancies, ID4 hypermethylation is correlated with shorter overall survival and leukaemia-free survival time, and it acts as an independent risk factor affecting overall survival in acute myeloid leukaemia. Additionally, ID4 methylation is increased during disease progression in chronic myeloid leukaemia. Overall, these findings suggest that ID4 is involved in cancer progression and may serve as a potential biomarker for diagnosis, prognosis, and treatment outcome in various types of cancer.
Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?
4 answers
Akkermansia muciniphila exhibits positive effects on host health by improving immunological and metabolic functions, making it a potential probiotic for neuropsychiatric disorders. It plays a vital role in various neurological and psychiatric disorders, such as depression, anxiety, Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, strokes, and autism spectrum disorders, by influencing the microbiota-gut-brain axis. A. muciniphila can restore the gut microbiota, regulate host immunity, and modulate gut and neuroinflammation to improve symptoms. However, its exact mechanism of action remains controversial. A. muciniphila has been studied extensively in metabolic diseases and shows potential as a therapeutic target in neuropsychiatric disorders. It protects the intestinal mucosal barrier, modulates the immune system, and influences metabolites, such as short-chain fatty acids, amino acids, and amino acid derivatives. Clinical studies assessing the therapeutic effects of A. muciniphila interventions in neuropsychiatric disorders are limited. A. muciniphila has been shown to alleviate depression in animal models, but further research is needed. The use of A. muciniphila should be evaluated on an individual basis, considering its potential effects in specific microenvironments and in patients with certain disorders. A specific subtype of A. muciniphila has been found to reduce body weight gain, improve spatial memory, and restore tryptophan metabolism in high-fat diet-fed mice.
What are the potential applications of genomics in osteoporosis management?
5 answers
Genomics has the potential to revolutionize osteoporosis management by providing insights into disease pathophysiology, identifying novel therapeutic targets, and improving clinical decision-making. Genome-wide association studies have identified multiple loci associated with bone mineral density and fracture risk, increasing our understanding of the disease. Implementing genetic information in drug development can help overcome current shortcomings in pharmaceutical research and lead to the identification of more successful drug targets. By revealing the underlying genetics and biology of osteoporosis, new and effective treatments can be developed. Additionally, pharmacogenetics, the utilization of individual genetic data to predict drug response, has the potential to tailor pharmacological treatments for osteoporosis patients. Overall, genomics offers opportunities for personalized medicine and improved management strategies for osteoporosis.
What are the downside of a cocktail syrup?
5 answers
Cocktail syrups can have several downsides. One major concern is the potential for drug interactions when multiple drugs are combined in a cocktail approach. This method of combining drugs to target specific molecules can lead to unpredictable effects and may not be suitable for all patients. Additionally, the use of cocktail syrups can increase the risk of adverse effects and toxicity, especially if the combination of ingredients is not well-studied or validated. Another downside is the potential for the "cocktail effect" in food and beverages, where the combination of multiple chemicals can have a more harmful impact on human health and the environment compared to individual chemicals. Furthermore, when it comes to alcoholic beverages, the sugars mixed with alcohol can impact the neurochemical and biological mechanisms influencing alcohol drinking and the development of alcohol use disorder. Overall, the downsides of cocktail syrups include drug interactions, increased risk of adverse effects, potential harm from chemical mixtures, and impacts on alcohol consumption and addiction.
What is the genetic diversity of cowpea populations?
3 answers
Cowpea populations exhibit significant genetic diversity, as revealed by multiple studies. The genetic diversity of cowpea landraces from Greece was assessed using seed phenotyping and SSR genotyping, which identified significant variation in seed morphological traits and genetic polymorphism. De novo genome assemblies of cultivated cowpea accessions from different subpopulations showed the presence of core and noncore genes, with noncore genes contributing to diversity within domesticated cowpea. Another study analyzed the genetic diversity of cowpea accessions from Sub-Saharan Africa using SNP markers, revealing four subpopulations and a low level of heterozygosity. Genetic diversity analysis of cowpea accessions from Portugal and Mozambique indicated the existence of two different gene pools, suggesting the potential for individual selection within landraces adapted to specific conditions. Additionally, RAPD marker analysis of different cowpea genotypes demonstrated a high degree of genetic variation. These findings highlight the rich genetic diversity present in cowpea populations, which can be valuable for breeding programs and the conservation of genetic resources.
Where are Langhans giant cells found?
5 answers
Langhans giant cells are found in granulomas of infectious etiology. They are a specific type of multinucleated giant cell characterized by a horseshoe-shaped ring of nuclei. These cells have been observed in mycobacterium-induced granulomasand are present in the tubercles of tuberculosis patients. The molecular characteristics of Langhans giant cells differ from those of macrophages, with unique gene expression patterns and functions. They are involved in maintaining hemostasis in granulomas. Langhans giant cells can be induced by cytokines such as IL-15, which triggers their formation through the direct interaction of activated T cells and myeloid cells.
What is the role of miR-93 in adipose-derived stem cells proliferation?
5 answers
miR-93 has not been specifically mentioned in the provided abstracts. None of the abstracts discuss the role of miR-93 in the proliferation of adipose-derived stem cells.
How to explain the inference results of Bayesian networks?
3 answers
Inference results of Bayesian networks can be explained by considering the representation of uncertainty and the computational resources required for the inference process. Bayesian networks use prior distributions and observed evidence to calculate posterior distributions, which quantify uncertainty in the predictions. The representation of uncertainty can be separated into aleatoric and epistemic uncertainty, with the joint distribution of predictive and epistemic uncertainty providing insights into the model's accuracy and the complexity of the dataset. The computational resources required for Bayesian inference can be analyzed using parameterized complexity classes, such as W[1]PP and XLPP, which relate to the number of variables and the topological vertex separation number. These results contribute to a better understanding of the computational aspects and uncertainty representation in Bayesian inference.
What is the role of miR-184 in adipose-derived stem cells proliferation?
5 answers
miR-184 has not been mentioned in any of the provided abstracts.
What impact do pharmaceutical companies have when risk-based monitoring is incorporated into whole?
5 answers
Pharmaceutical companies have a significant impact when risk-based monitoring is incorporated into their practices. By shifting monitoring processes from excessive source data verification to comprehensive risk-driven monitoring, companies can increase efficiencies, enhance patient safety, and maintain data integrity. This shift involves using available data to monitor, assess, and mitigate overall trial risks, while also deploying centralized and off-site mechanisms to monitor trial parameters holistically. The incorporation of risk-based monitoring strategies can lead to cost savings for pharmaceutical companies, as traditional on-site monitoring methods can be resource-intensive and expensive. Regulatory agencies, such as the U.S. Food and Drug Administration and the European Medicines Agency, have encouraged the adoption of risk-based monitoring approaches, emphasizing the importance of analyzing data regularly and targeting on-site monitoring activities. Overall, the integration of risk-based monitoring into pharmaceutical companies' practices can improve efficiency, reduce costs, and ensure the quality and safety of clinical trials.