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What is the appropriate measure of relative risk for a cohort study? 

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Open accessJournal ArticleDOI
01 Aug 2009-Stata Journal
270 Citations
The risk ratio can be a useful statistic for summarizing the results of cross-sectional, cohort, and randomized trial studies.
A competing-risk approach must be used to analyze the risk of events other than death in cohort studies, particularly when mortality rates are high.
It is suggested that the summary statistics of a cohort mortality experience should include relative risk, attributable risk, and life expectancy.
Given the same cohort method (historical prospective), cohort results vary widely according to different study designs, and this has implications for "generalizable" risk assessment or risk projections.
The case-cohort study design is a useful modification of the case-control design, which allows direct estimation of the risk ratio without the rare-disease assumption.
Results of this paper may be useful in assessing the validity of the model of a common relative risk before combining several 2 x 2 tables or in designing a prospective study for detecting heterogeneity of relative risks.
If there is reasonable agreement between cohort-specific relative risk estimates, a more powerful pooled summary estimate can be obtained.

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