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At a cost of $460 for founder mutation testing, the cost of the program is $8300 (discounted) per year of quality-adjusted life gained. In populations with a high prevalence of BRCA1/2 founder mutations, genetic screening may be cost-effective when compared with recommended public health interventions such as mammographic screening.
Since this seems to be too great a mutation load, we may assume 0·5 v is located within the specified interval if the physiological cost of a twofold reduction of the mutation rate is within the range 10–80%.
MAIN RESULTS AND THE ROLE OF CHANCE At a willingness-to-pay threshold of $50 000 per QALY, IVF/PGT-M is a cost-effective intervention for carriers of either BRCA mutation.
Maintenance of mutation rates higher than the minimum set by this “cost of fidelity” is likely only under special circumstances.
Open accessProceedings Article
01 Jan 2010
10 Citations
Additionally, the results suggest that some of the proposed approaches are more effective than others making it possible to reduce the mutation testing application cost with only a limited impact on its
We found that cost reduction for mutation is increasingly becoming interdisciplinary, often combining multiple techniques.
Indeed, some mutations do not result in a fitness cost, and in case they do, the cost may be compensated for by a secondary mutation.
At a WTP of 10,000 € per QALY, the probability of the intervention being cost-effective was 80%.From the SHI perspective, undergoing BM plus immediate BSO should be recommended to BRCA 1 or 2 mutation carriers due to its favorable comparative cost-effectiveness.
The high cost is due, in part, to redundant mutants generated by commonly used mutation operators.
The result obtained or the cost of congestion estimated for the city of Kolkata indicates that there is a considerable monetary loss that is being incurred.

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