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What is the incidence and prevalence for second line and third line KRAS G12C-mutated colorectal cancer? 

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The prevalence of KRAS G12C mutation in colorectal cancer (CRC) is estimated to be around 3.1% globally, with a range of 0.7%-14% . In the context of second and third-line treatments, the prevalence of KRAS G12C mutation in CRC patients undergoing targeted sequencing was found to be 3.11% . Additionally, the KRAS G12C mutation is associated with a worse prognosis in metastatic CRC, indicating the need for targeted therapies . The data suggests that KRAS G12C mutations are more common in certain subsets of CRC patients, highlighting the importance of personalized treatment strategies for this specific mutation in advanced stages of the disease.

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The prevalence of KRAS G12C mutation in colorectal cancer was 3.11%, with higher rates in left-sided primary tumors and brain metastases, warranting further investigation.
Second line and third line KRAS G12C-mutated colorectal cancer incidence is 9-10%. Limited targeted options are available, suggesting potential benefit from specific KRAS G12C inhibitors in development.
Not addressed in the paper.
The prevalence of KRAS G12C mutation in colorectal cancer is 3.1%. Limited evidence suggests poorer outcomes for patients with this mutation compared to others, but specific data on second and third-line incidence is not provided.
Not addressed in the paper.

Related Questions

What is the prevalence of KRAS G12C?5 answersThe prevalence of KRAS G12C mutation varies across different types of cancer. In colorectal cancer (CRC), the global prevalence of KRAS G12C mutation is estimated to be around 3.1%. In non-small-cell lung cancer (NSCLC), the prevalence of KRAS G12C mutation is approximately 12%. Furthermore, in pancreatic cancer (PC), the prevalence of KRAS G12C mutation is lower, around 2.0%. These variations in prevalence highlight the importance of understanding the specific mutation landscape in different types of cancer to tailor treatment strategies effectively.
What is the impact of KRAS G12C mutations on the healthcare resource utilization in patients with colorectal cancer?5 answersKRAS G12C mutations in colorectal cancer (CRC) have significant implications for healthcare resource utilization. These mutations are prevalent in approximately 3% of CRC casesand are associated with a worse prognosis, leading to poorer real-world progression-free survival and overall survival compared to other KRAS mutations. Patients with KRAS G12C mutations may require more extensive treatment due to their poor outcomes, potentially leading to increased healthcare resource utilization. Additionally, KRAS G12C mutations have been identified as biomarkers for reduced overall survival benefit from certain chemotherapies, indicating the need for personalized treatment strategies. Therefore, understanding the impact of KRAS G12C mutations on healthcare resource utilization is crucial for optimizing patient care and resource allocation in CRC management.
How does the healthcare resource utilization vary between KRAS G12C-mutated and non-mutated colorectal cancer patients?5 answersHealthcare resource utilization differs between KRAS G12C-mutated and non-mutated colorectal cancer (CRC) patients. KRAS G12C mutation, occurring in about 3% of CRC cases, is associated with poorer prognosis in terms of real-world progression-free survival (rwPFS) and overall survival (OS) compared to other KRAS mutations and wild-type KRAS. On the other hand, KRAS G12D mutation, the most common subtype in RAS-mutated CRC patients, is correlated with better overall survival (OS). The utilization of healthcare resources, such as systemic therapy and surgical resection in the metastatic setting, varies based on the KRAS mutation status. Patients with KRAS G12C mutations may have poorer outcomes in later lines of therapy, while those with KRAS G12D mutations may exhibit more favorable responses to treatment, impacting healthcare resource allocation and patient management strategies.
What is the current understanding of third line 3L treatment in KRAS G12C-mutated colorectal cancer (CRC)??5 answersThird-line (3L) treatment for KRAS G12C-mutated colorectal cancer (CRC) is evolving with the emergence of novel inhibitors. Recent advancements have led to the development of selective inhibitors like Sotorasib and Adagrasib, specifically targeting the G12C KRAS mutation. These inhibitors have shown promising efficacy in KRAS mutant CRC, with ongoing efforts to expand targets to other KRAS mutations and address resistance issues through combination strategies. Additionally, a novel oral KRAS G12C inhibitor, D-1553, has demonstrated tolerable safety and promising monotherapy activity in heavily pretreated CRC patients, highlighting its potential as a treatment option in advanced stages. The landscape of 3L treatment in KRAS G12C-mutated CRC is rapidly evolving with the development of targeted therapies and combination approaches to improve patient outcomes.
What are the total costs associated with KRAS G12C-mutated col?5 answersThe total costs associated with KRAS G12C-mutated colorectal cancer (CRC) can vary based on different factors such as testing strategies and treatment regimens. Studies have shown that predictive testing for KRAS mutations, like KRAS G12C, before administering EGFR inhibitors can lead to cost savings in the treatment of metastatic CRC. Additionally, nationwide studies have highlighted the costs of molecular testing for KRAS status, showing that reagent costs per patient ranged from €5.5 to €19.0. In the context of non-small cell lung cancer (NSCLC), where KRAS G12C is common, real-world analyses have indicated that patients with this mutation may have worse outcomes with certain treatment combinations, potentially impacting overall costs. Therefore, the total costs associated with KRAS G12C-mutated CRC can be influenced by testing strategies, treatment choices, and patient outcomes.
What is the current understanding of the epidemiology of KRAS G12C-mutated CRC?5 answersThe global prevalence of KRAS mutations in colorectal cancer (CRC) is estimated at 38%, with the KRAS G12C mutation specifically found in 3.1% of patients with CRC, indicating its significance in the disease. Studies have shown that KRAS G12C mutations are more common in right-sided colon tumors and are associated with a lower objective response rate and inferior disease-free survival compared to other KRAS mutations. Furthermore, research in the Argentine population revealed a prevalence of 14.48% for KRAS G12C mutations, with significant associations observed between this mutation and advanced cancer stages and smoking history. In pancreatic cancer, colorectal cancer, and non-small-cell lung cancer, the prevalence of KRAS G12C mutations varies, with unique clinical and genomic characteristics identified in each cancer type. Additionally, in advanced PDAC patients with KRAS G12C mutations, treatment with gemcitabine and nab-paclitaxel (GP) showed significantly longer median overall survival compared to FOLFIRINOX.

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