scispace - formally typeset
Search or ask a question

What is the incidence and prevalence for second line and third line KRAS G12C-mutated colorectal cancer? 


Best insight from top research papers

The prevalence of KRAS G12C mutation in colorectal cancer (CRC) is estimated to be around 3.1% globally, with a range of 0.7%-14% . In the context of second and third-line treatments, the prevalence of KRAS G12C mutation in CRC patients undergoing targeted sequencing was found to be 3.11% . Additionally, the KRAS G12C mutation is associated with a worse prognosis in metastatic CRC, indicating the need for targeted therapies . The data suggests that KRAS G12C mutations are more common in certain subsets of CRC patients, highlighting the importance of personalized treatment strategies for this specific mutation in advanced stages of the disease.

Answers from top 5 papers

More filters
Papers (5)Insight
The prevalence of KRAS G12C mutation in colorectal cancer was 3.11%, with higher rates in left-sided primary tumors and brain metastases, warranting further investigation.
Second line and third line KRAS G12C-mutated colorectal cancer incidence is 9-10%. Limited targeted options are available, suggesting potential benefit from specific KRAS G12C inhibitors in development.
Not addressed in the paper.
The prevalence of KRAS G12C mutation in colorectal cancer is 3.1%. Limited evidence suggests poorer outcomes for patients with this mutation compared to others, but specific data on second and third-line incidence is not provided.
Not addressed in the paper.

Related Questions

What is the prevalence of KRAS G12C?5 answersThe prevalence of KRAS G12C mutation varies across different types of cancer. In colorectal cancer (CRC), the global prevalence of KRAS G12C mutation is estimated to be around 3.1%. In non-small-cell lung cancer (NSCLC), the prevalence of KRAS G12C mutation is approximately 12%. Furthermore, in pancreatic cancer (PC), the prevalence of KRAS G12C mutation is lower, around 2.0%. These variations in prevalence highlight the importance of understanding the specific mutation landscape in different types of cancer to tailor treatment strategies effectively.
What is the impact of KRAS G12C mutations on the healthcare resource utilization in patients with colorectal cancer?5 answersKRAS G12C mutations in colorectal cancer (CRC) have significant implications for healthcare resource utilization. These mutations are prevalent in approximately 3% of CRC casesand are associated with a worse prognosis, leading to poorer real-world progression-free survival and overall survival compared to other KRAS mutations. Patients with KRAS G12C mutations may require more extensive treatment due to their poor outcomes, potentially leading to increased healthcare resource utilization. Additionally, KRAS G12C mutations have been identified as biomarkers for reduced overall survival benefit from certain chemotherapies, indicating the need for personalized treatment strategies. Therefore, understanding the impact of KRAS G12C mutations on healthcare resource utilization is crucial for optimizing patient care and resource allocation in CRC management.
How does the healthcare resource utilization vary between KRAS G12C-mutated and non-mutated colorectal cancer patients?5 answersHealthcare resource utilization differs between KRAS G12C-mutated and non-mutated colorectal cancer (CRC) patients. KRAS G12C mutation, occurring in about 3% of CRC cases, is associated with poorer prognosis in terms of real-world progression-free survival (rwPFS) and overall survival (OS) compared to other KRAS mutations and wild-type KRAS. On the other hand, KRAS G12D mutation, the most common subtype in RAS-mutated CRC patients, is correlated with better overall survival (OS). The utilization of healthcare resources, such as systemic therapy and surgical resection in the metastatic setting, varies based on the KRAS mutation status. Patients with KRAS G12C mutations may have poorer outcomes in later lines of therapy, while those with KRAS G12D mutations may exhibit more favorable responses to treatment, impacting healthcare resource allocation and patient management strategies.
What is the current understanding of third line 3L treatment in KRAS G12C-mutated colorectal cancer (CRC)??5 answersThird-line (3L) treatment for KRAS G12C-mutated colorectal cancer (CRC) is evolving with the emergence of novel inhibitors. Recent advancements have led to the development of selective inhibitors like Sotorasib and Adagrasib, specifically targeting the G12C KRAS mutation. These inhibitors have shown promising efficacy in KRAS mutant CRC, with ongoing efforts to expand targets to other KRAS mutations and address resistance issues through combination strategies. Additionally, a novel oral KRAS G12C inhibitor, D-1553, has demonstrated tolerable safety and promising monotherapy activity in heavily pretreated CRC patients, highlighting its potential as a treatment option in advanced stages. The landscape of 3L treatment in KRAS G12C-mutated CRC is rapidly evolving with the development of targeted therapies and combination approaches to improve patient outcomes.
What are the total costs associated with KRAS G12C-mutated col?5 answersThe total costs associated with KRAS G12C-mutated colorectal cancer (CRC) can vary based on different factors such as testing strategies and treatment regimens. Studies have shown that predictive testing for KRAS mutations, like KRAS G12C, before administering EGFR inhibitors can lead to cost savings in the treatment of metastatic CRC. Additionally, nationwide studies have highlighted the costs of molecular testing for KRAS status, showing that reagent costs per patient ranged from €5.5 to €19.0. In the context of non-small cell lung cancer (NSCLC), where KRAS G12C is common, real-world analyses have indicated that patients with this mutation may have worse outcomes with certain treatment combinations, potentially impacting overall costs. Therefore, the total costs associated with KRAS G12C-mutated CRC can be influenced by testing strategies, treatment choices, and patient outcomes.
What is the current understanding of the epidemiology of KRAS G12C-mutated CRC?5 answersThe global prevalence of KRAS mutations in colorectal cancer (CRC) is estimated at 38%, with the KRAS G12C mutation specifically found in 3.1% of patients with CRC, indicating its significance in the disease. Studies have shown that KRAS G12C mutations are more common in right-sided colon tumors and are associated with a lower objective response rate and inferior disease-free survival compared to other KRAS mutations. Furthermore, research in the Argentine population revealed a prevalence of 14.48% for KRAS G12C mutations, with significant associations observed between this mutation and advanced cancer stages and smoking history. In pancreatic cancer, colorectal cancer, and non-small-cell lung cancer, the prevalence of KRAS G12C mutations varies, with unique clinical and genomic characteristics identified in each cancer type. Additionally, in advanced PDAC patients with KRAS G12C mutations, treatment with gemcitabine and nab-paclitaxel (GP) showed significantly longer median overall survival compared to FOLFIRINOX.

See what other people are reading

What is often used in the cathode chamber of double chambered microbial fuel cell?
5 answers
The cathode chamber of a double-chambered microbial fuel cell (MFC) often utilizes various materials and configurations to enhance performance. Studies have shown that different electrode combinations, such as carbon nanotube (CNT)-modified carbon graphite electrodes, stainless steel (SS) and graphite fibre brush (GFB) electrodes, and air cathodes, have been employed in the cathode chamber to improve power density, voltage, and decolorization efficiency. Additionally, the use of biocathodes with heat-treated electrodes has been explored to enhance cathode reaction performance in MFC systems. These findings highlight the versatility and importance of selecting suitable materials and configurations for the cathode chamber of double-chambered microbial fuel cells to optimize bioelectricity generation and dye removal processes.
What role does visual support play in packing for individuals with autism?
4 answers
Visual supports play a crucial role in assisting individuals with autism spectrum disorder (ASD) in various aspects of their lives. These supports, such as picture task cards, visual activity schedules, and video prompting, are beneficial tools for enhancing communication, understanding concepts, and navigating the environment. In the context of packing, visual supports can aid individuals with ASD by reducing anxiety, increasing predictability, and supporting organization. They provide clear expectations, routine, and structure, which are particularly helpful for individuals with ASD when preparing for activities like packing. Music therapists often utilize visual supports, such as pictures with written words and visual schedules, to enhance sessions and interventions for individuals with ASD. Therefore, incorporating visual supports in the packing process can significantly benefit individuals with autism by promoting independence and reducing stress.
Latest papers on motor learning within neurological rehabilitation?
5 answers
Recent research has highlighted the significance of motor learning in neurological rehabilitation. Studies emphasize incorporating motor control theoriesand utilizing tools like noninvasive brain stimulation to enhance motor learning. Motor learning principles have shown positive outcomes in stroke rehabilitation, aiding in the recovery of movement patterns. Additionally, the integration of neural substrates, behavioral drivers, cognitive load, and timescale development is crucial for effective motor learning strategies across different populations. Virtual reality applications are also being explored to facilitate sensorimotor recovery by manipulating practice structures and feedback. Overall, these findings underscore the importance of tailored motor learning interventions in enhancing sensorimotor recovery and promoting functional improvements in patients undergoing neurological rehabilitation.
Are there any psychology papers on how the prediction error determines the sensory attention?
5 answers
Research in psychology has extensively explored how prediction errors influence sensory attention. Studies have shown that prediction errors, such as the visual mismatch negativity (vMMN), play a crucial role in sensory processing. These prediction errors are indexed by event-related potentials like MMN and P300, reflecting automatic comparisons between stimuli and cognitive processes like attention. Furthermore, the relationship between prediction errors and attention has been investigated in visual perception, demonstrating their interaction and dissociation in distinct stages during information processing. Additionally, it has been suggested that attention optimizes the precision of predictions by modulating the gain of prediction errors, enhancing the selectivity for mismatch information in response to surprising stimuli. These findings collectively highlight the intricate interplay between prediction errors and sensory attention in shaping cognitive processes.
CD spectra of pure bacterial dna?
4 answers
CD spectra of pure bacterial DNA have been extensively studied using circular dichroism (CD) spectroscopy. Different forms of bacterial DNA, such as those from the Ff group of bacterial viruses, exhibit distinct CD signatures. The CD spectrum of a single-stranded DNA binding protein, g5p, shows significant changes upon binding to nucleic acids, with specific tyrosine residues playing a crucial role in these spectral perturbations. Additionally, CD analysis of various bacterial DNA forms, including A-, B-, and C-forms, in the vacuum-ultraviolet region has revealed characteristic positive and negative bands sensitive to the DNA source and base-base interactions, providing insights into their secondary structures and base pairing interactions. These studies highlight the utility of CD spectroscopy in elucidating the structural characteristics of bacterial DNA.
How accurate is the SIC score in predicting mortality among patients with sepsis-induced coagulopathy?
5 answers
The Sepsis-induced Coagulopathy (SIC) score demonstrates good accuracy in predicting mortality among patients with sepsis-induced coagulopathy. Studies have shown that the SIC score is effective in distinguishing patients at risk of adverse outcomes. It has been found that SIC subphenotypes can be identified through clinical and laboratory variables, aiding in the stratification of patients for targeted therapies. Additionally, the SIC score, when combined with other factors like lymphocyte count, enhances its predictive value for patient prognosis, making it a valuable tool for early assessment of patient condition and mortality risk. Overall, the SIC score is a reliable indicator for predicting mortality in patients with sepsis-induced coagulopathy, offering insights for better management and treatment decisions.
What is moore's law?
5 answers
Moore's Law refers to the observation made by Gordon Moore that the number of transistors on a microchip doubles approximately every two years, leading to exponential growth in computing power over time. Initially, this trend drove advancements in the semiconductor industry, but its relevance has evolved over the years. While some argue that Moore's Law is reaching its limits due to factors like atomic scales and energy consumption, others propose shifting towards a new perspective termed the Feynman Mandate for assessing progress more broadly. Moore's Law has played a crucial role in shaping the semiconductor industry, driving innovation, and setting the pace for technological development.
How does the age and overall health of a patient affect the success rate of meniscus debridement surgery?
5 answers
Age plays a crucial role in the success rate of meniscus debridement surgery. Younger patients, particularly those under 30 years old, are more likely to undergo meniscal repair, which is associated with better outcomes. Conversely, older patients, especially those aged 50 years or above, have a higher risk of clinical failure after arthroscopic partial meniscectomy (APM) for medial meniscus tears. Additionally, the overall health of the patient, as indicated by factors like body mass index (BMI) and the presence of osteoarthritis, can impact the efficacy of meniscus surgery. Therefore, considering age, BMI, and osteoarthritis status is essential in determining the success of meniscus debridement procedures, with younger age groups generally showing better outcomes compared to older individuals.
What is the definition of source of data in research methodology?
5 answers
The source of data in research methodology refers to the origin or location from which data is collected for analysis. It encompasses various categories such as information, network, devices, and visualization. Data can be derived from text, survey responses, ethnographies, experiments, and observational research, reflecting the diverse sources available in translation and interpreting studies (TIS) research. Understanding the source of data is crucial as it influences the quality and reliability of research findings. Researchers often employ different data collection techniques to gather information from these varied sources, ensuring a comprehensive and robust dataset for analysis. In essence, the source of data forms the fundamental basis for scholarly inquiry and shapes the research process in terms of data collection, analysis, and interpretation.
What is the Source of data about positive and negative effect?
5 answers
The data about positive and negative effectivity comes from the Chinese Longitudinal Healthy Longevity Survey conducted in 2008, 2012, 2014, and 2018, involving 10,993 elderly individuals aged 65 and above. This study compared the levels of positive and negative effectivity among different gender and age groups and analyzed their impact on the mortality risk of the elderly. The results highlighted that higher positive effectivity, including factors like "clean preference," "autonomy," and "sense of youth," was associated with a lower mortality risk, while negative effectivity, such as "tension and fear," "loneliness," and "uselessness," increased the mortality risk among the elderly. The study emphasizes the importance of addressing negative emotions promptly and promoting positive effectivity for better health outcomes in the elderly.
What is congo red?
4 answers
Congo red is a versatile compound with various applications. It is utilized in the detection and inhibition of protein aggregates related to diseases like Alzheimer's and diabetes. Additionally, Congo red enhances the bioavailability of doxorubicin in breast cancer cells by cutting doxorubicin aggregates and aiding in their transfer through membranes. Moreover, Congo red dye has been found to protect bacteriophages from UV radiation, facilitating membrane cleaning in biofoundries. In fungal studies, Congo red is used as a stressor to induce priming against UV-B radiation, enhancing tolerance in organisms like Metarhizium robertsii. Furthermore, Congo red has shown potential in optoelectronic applications, as demonstrated in the fabrication of photodiodes, indicating its sensitivity to light and suitability for such purposes.