What is the most biocompatible dialyzer membrane?
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23 Citations | Among cellulosic membranes, HE is the most biocompatible and appears to be an important step in preventing blood-membrane interactions and related complications. |
13 Citations | Current evidence implicates the dialyzer as the most likely culprit, and our experience suggests that none of the commonly used dialysis membranes are truly biocompatible. |
24 Citations | Meanwhile, the membrane is biocompatible and can support the adherence, growth, and survival of human cells. |
52 Citations | Key Messages: Highly biocompatible dialysis membranes can be developed when the overall correlations among biological reactions are examined by integrating all data on biological responses elicited by blood-membrane interactions or mutual interactions among blood cells. |
11 Citations | The two high-flux membranes were very hemocompatible and require only low doses of heparin, but the dialyzer with AN 69 membrane need its geometry improving. |
9 Citations | The choice of dialyzer membrane material does not affect most aspects of biocompatibility when patients have significant systemic inflammation. |
16 Citations | From these findings two lines of evidence emerge: First, not only the type of membrane material used in a dialyzer may influence its biocompatibility, but the geometry of the extracorporeal device also determines the degree of compatibility. |
38 Citations | Ideal membrane material should be biocompatible with tissue integration, be able to create and maintain space, be occlusive with selective permeability, and have good handling properties. |
| This retrospective analysis shows that bioincompatibility of dialyzer membranes may be more important for the outcome of patients with ARF than the dose of dialysis. | |
14 Citations | Biocompatible dialyzer membranes may both limit oxidative stress and decrease &bgr;2-microglobulin production, thereby reducing patient morbidity. |
Related Questions
Is the assertion that CaP's biocompatibility is limited to a Ca/P ratio from 1.5 to 1.67 overly restrictive?5 answersThe assertion that the biocompatibility of calcium phosphate (CaP) is limited to a Ca/P ratio from 1.5 to 1.67 may be overly restrictive. Studies have shown that the biocompatibility of CaP can be influenced by various factors beyond just the Ca/P ratio. Research has demonstrated that CaP composites incorporating poly (D,L-lactic-co-glycolic acid) (PLGA) microparticles exhibit minimal inflammatory responses and are considered biocompatible for bone tissue engineering applications. Additionally, the biocompatibility of nanoscaled CaP scaffolds was found to be affected by factors like pH value and metal ion concentration, indicating that these parameters significantly impact biocompatibility. Furthermore, surface functionalization of CaP nanoparticles has shown promising transfection efficacy and excellent biocompatibility, suggesting that factors beyond the Ca/P ratio play a role in determining biocompatibility.
What are the properties of an ideal membrane surface for hemodialysis membranes?5 answersAn ideal membrane surface for hemodialysis should possess characteristics such as outstanding hydrophilicity, hemocompatibility, charge neutrality, wettability, and functionality. It should also exhibit antifouling capabilities, stable protein-resistance properties, and be bio-inert, hydrophilic, and electrically neutral. The membrane should have a smooth surface, high biocompatibility, and a negatively charged surface for extracorporeal adsorptive filtration from blood/plasma, along with anti-inflammatory and anti-thrombogenic effects. Additionally, the membrane should be durable, have good tensile strength, and be capable of removing toxins efficiently through a combination of adsorption and diffusion mechanisms. These properties collectively contribute to enhancing dialysis efficiency, improving patient outcomes, and reducing the risk of complications associated with hemodialysis treatment.
What are the differences in the biocompatibility of alumina and hydroxyapatite?4 answersAlumina and hydroxyapatite have different levels of biocompatibility. Hydroxyapatite is known for its excellent biocompatibility, making it suitable for various biomedical applications such as bone tissue engineering, drug delivery systems, and dental applications. On the other hand, while alumina has high mechanical properties, its bioinertness limits its application for permanent bone implants. However, when combined with hydroxyapatite, the mechanical properties of alumina can be enhanced while still maintaining biocompatibility. The addition of hydroxyapatite to alumina can result in composites with improved bioactive properties and biocompatibility. The biocompatibility of the composites can be evaluated through in vitro and in vivo tests, which have shown good compatibility with cells and the ability to support cell attachment and growth. Overall, hydroxyapatite exhibits excellent biocompatibility, while the addition of hydroxyapatite to alumina can enhance the biocompatibility of the composite materials.
What are the most biocompatible resins for use in dentistry?5 answersPoly-methylmethacrylate (PMMA) based resins are widely used in dentistry and are considered cytotoxic due to the leaching of potential toxic substances, such as residual monomer. However, thermoplastic resins, including polyamides, acetal resins, and acrylic thermoplastic resins, have been introduced as alternatives to classic resins and are considered biocompatible and non-toxic. Additionally, new types of acrylic resins have been developed for use in Computer-Aided Design/Computer-Aided Manufacturing systems and three-dimensional printing, which have improved mechanical and biological properties. Furthermore, a study evaluated different adhesive restoration materials and found that some adhesive resins, such as Silorane Primer and Ketac N 100 Primer, showed low monomer release and were considered biocompatible. Overall, thermoplastic resins and certain adhesive resins have been shown to be biocompatible options for use in dentistry.
What makes an hydrogel biocompatible for bacteria encapsulation?5 answersBiocompatibility of hydrogels for bacteria encapsulation is determined by several factors. The hydrogel should have a stable and structurally robust architecture to prevent rupture and leakage of encapsulated cells. The composition and morphology of the hydrogel also play a role in its biocompatibility. Positively charged hydrogels based on azamacrocycles minimize electrostatic repulsions and exhibit a stable structure. Physical and chemical hydrogels based on chitosan and dextran sulfate can be tuned to have suitable swelling properties and robust structures for cell encapsulation. The design of the hydrogel itself is important, with an amphiphilic nature facilitating gelation and the ability to capture solvent molecules. Additionally, a biocompatible hydrogel should be noncytotoxic and provide a favorable environment for the growth of bacteria. Overall, a combination of structural stability, composition, morphology, and biocompatibility is necessary for a hydrogel to be suitable for bacteria encapsulation.
What is Mineral Bioacessibility by dialysis method?5 answersMineral bioaccessibility by dialysis method refers to the removal of mineral impurities from substances, such as mineral oil or the blood of dialysis patients, using a dialysis process. Dialysis is commonly used in the treatment of chronic kidney disease (CKD) and is known to be effective in removing excess minerals from the blood, such as calcium and phosphorus, which can lead to complications like vascular calcification and mineralization. In the context of dialysis patients, mineral bioaccessibility is important in maintaining optimal mineral and bone metabolism, as disorders in calcium, phosphorus, and parathyroid hormone levels are common in CKD and can contribute to poor outcomes. By effectively removing mineral impurities, dialysis can help prevent complications associated with mineral and bone disorders, such as cardiovascular risk, fracture, and mortality. Additionally, dialysis can also play a role in reducing "phosphate toxicity" and minimizing the risk of developing vascular mineralization in CKD patients.