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What is the quality of life in KRAS G12C-mutated CRC? 


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Patients with KRAS G12C-mutated colorectal cancer (CRC) exhibit poor outcomes, including real-world progression-free survival (rwPFS) and overall survival (OS). In metastatic CRC (mCRC) patients with KRAS G12C mutation, median OS from the start of first-line therapy was 33.5 months, with rwPFS of 20.9 months from the same point. However, in later lines of therapy, outcomes were notably poorer, with median OS decreasing to 15.8 months and rwPFS dropping to 3.1 months from the start of the third line of therapy. These findings suggest that while initial outcomes may be more favorable, the quality of life in KRAS G12C-mutated CRC deteriorates in subsequent lines of treatment, highlighting the need for more effective targeted therapies for this patient population.

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KRAS p.G12C mutation in metastatic CRC is linked to a poorer prognosis. The paper discusses advancements in targeted therapies, highlighting KRAS G12C as a promising therapeutic target.
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What are the potential side effects and long-term outcomes associated with second-line 2L treatment in KRAS G12C-mutated col?5 answersSecond-line (2L) treatment in KRAS G12C-mutated colorectal cancer (CRC) may lead to poor outcomes and specific side effects. Research on KRAS G12C-mutated mCRC patients showed that median progression-free survival (rwPFS) from the start of second-line therapy was only 4.0 months, with a median overall survival (OS) of 20.7 months from the same point. Additionally, KRAS G12C-mutated mCRC patients had a median OS of 33.5 months from the start of the first line of therapy, indicating a decline in survival over subsequent treatments. These patients often experienced late-onset treatment-related toxicities, although these did not typically lead to treatment discontinuation. Therefore, second-line treatments for KRAS G12C-mutated CRC may offer limited benefits and potentially challenging side effects, necessitating the exploration of more effective therapeutic options.
What is quality of life?4 answersQuality of life is a multidimensional concept that encompasses an individual's perceptions, satisfaction, and evaluation of different areas of their own lives, such as physical health, psychological well-being, social roles, and relationships. It is a subjective and dynamic measure that varies among individuals and can change over time. The World Health Organization (WHO) defines quality of life as an individual's perception of their position in life in relation to their goals, expectations, and concerns, influenced by their physical health, psychological state, level of independence, social relationships, and environment. Quality of life is a broad and complex concept that presents challenges in its measurement and interpretation. It is an umbrella term that encompasses the quality of various domains in life. The term is broad and subjective, making it challenging to reach a consensus on its measurement, but measures are most meaningful when they measure key concepts in a logical and precise way.
How does in-stent restenosis affect the quality of life?4 answersIn-stent restenosis (ISR) is a common complication after percutaneous coronary intervention (PCI) and can have a significant impact on the quality of life. ISR is associated with an increased risk of death and rehospitalization, leading to higher healthcare costs. The treatment of ISR often requires repeat revascularization procedures, which can pose a therapeutic challenge and result in additional physical and emotional burden for patients. ISR can also lead to serious cardiac events, including myocardial infarction and stroke recurrence. The presence of ISR may require prolonged dual antiplatelet therapy, which can be associated with patient compliance issues and an increased risk of bleeding. Overall, ISR can negatively affect the quality of life by causing additional healthcare utilization, increased risk of adverse events, and the need for repeat procedures and prolonged medication regimens.
What is quality of life?5 answersQuality of life is a multidimensional concept that encompasses an individual's perceptions, satisfaction, and evaluation of different areas of their own lives, such as physical health, psychological well-being, social roles, and relationships. It is a subjective and dynamic measure that depends on people's values, priorities, experiences, and aspirations. The World Health Organization (WHO) defines quality of life as an individual's perception of their position in life in relation to their goals, expectations, standards, and concerns. It is influenced by physical health, psychological state, level of independence, social relationships, and the environment. Quality of life measures can be generic or disease-specific questionnaires, such as the WHOQOL instruments and QLQ questionnaire. Quality of life is also important in medical sciences as it helps in assessing the health status of individuals, choosing therapeutic strategies, and evaluating the clinical outcomes of patients. Overall, quality of life is a complex and subjective concept that plays a crucial role in understanding and improving individuals' well-being.
Quality of life in osteogenesis imperfecta?5 answersQuality of life in osteogenesis imperfecta (OI) is impacted by physical, social, and emotional factors. Individuals with OI experience reduced physical function, pain, fear, isolation, and dependence, which negatively affect their quality of life. However, mental and psychosocial quality of life in individuals with OI is comparable to or better than that of the general population. The severity of OI and physical manifestations such as fractures, bone deformity, and bone pain contribute to lower levels of physical quality of life. The impact of OI on the lives of young patients and their parents is characterized by stages of adjustment, challenges, and significant changes in daily life. A multidisciplinary approach to the treatment of OI, involving medical, surgical, and allied health professionals, aims to maximize function, independence, and well-being for children and young people with OI.
How to write quality of life?6 answers

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