What is the role of melatonin in osteoporosis?
Best insight from top research papers
Melatonin plays a significant role in osteoporosis by improving osteogenic differentiation and inhibiting inflammation in bone mesenchymal stem cells (BMSCs) . It also promotes osteogenesis and suppresses osteoclastogenesis, directly affecting bone remodeling . Additionally, melatonin has been found to regulate the biological rhythm of bone tissue and attenuate damage caused by oxidative stress and inflammation on osteoblasts . The hormone has demonstrated therapeutic potential in the bone microenvironment, with effects including the regulation of bone metabolism, acceleration of osteoblastogenesis, and inhibition of osteoclastogenesis . Furthermore, melatonin treatment has been shown to stimulate osteogenic differentiation and alleviate osteoporosis symptoms in mice, potentially through the upregulation of thioredoxin1 (TRX1) . Overall, melatonin has the potential to be used for the treatment of osteoporosis by improving bone metabolism, promoting osteogenesis, and reducing bone loss .
Answers from top 5 papers
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| Papers (5) | Insight |
|---|---|
07 Feb 2022 | Melatonin stimulates osteogenic differentiation and alleviates osteoporosis symptoms by upregulating thioredoxin1 (TRX1) expression. |
9 Citations | Melatonin has therapeutic potential in the bone microenvironment, including the regulation of bone metabolism, acceleration of osteoblastogenesis, and inhibition of osteoclastogenesis, suggesting it may be useful in treating osteoporosis. |
| The role of melatonin in osteoporosis is to promote osteogenesis, suppress osteoclastogenesis, regulate the biological rhythm of bone tissue, and attenuate damage from oxidative stress and inflammation. | |
| Melatonin has the potential to improve osteogenic differentiation and relieve inflammation in bone mesenchymal stem cells, suggesting it may have therapeutic potential for osteoporosis. | |
3 Citations | Melatonin is used in preventing senile, postmenopausal, and neurodegenerative osteoporosis, according to the paper. |
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