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What is the role of NRF2 in diabetes? 


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NRF2 plays a crucial role in diabetes by regulating redox balance, inflammation, and fibrosis in major diabetic complications such as diabetic nephropathy (DN), diabetic cardiomyopathy (DC), and diabetic neuropathy. Activation of NRF2 signaling helps to dampen inflammation, oxidative damage, and interstitial fibrosis in these complications . Dysregulation of NRF2 signaling has been observed in various human diseases, including diabetes . NRF2 is a critical transcription factor that regulates redox, protein, and metabolic homeostasis, and its proper function is essential in preventing the onset of diabetic outcomes . Depletion of NRF2 in beta-cells leads to decreased glucose-stimulated beta-cell proliferation and mass expansion, while activating NRF2 increases beta-cell proliferation and mass, improving glucose tolerance . Therefore, NRF2 is a promising therapeutic target for expanding and protecting beta-cell mass in diabetes .

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NRF2 regulates β-cell mass by protecting β-cells from apoptosis and promoting β-cell proliferation, making it a potential therapeutic target for expanding and protecting β-cell mass in diabetes.
The paper discusses the role of NRF2 in diabetes progression and its regulation of redox, protein, and metabolic homeostasis. However, the mechanisms by which NRF2 modulates diabetes progression are still not fully understood.
The role of NRF2 in kidney dysfunction in diabetes is still unclear according to the provided paper.
The paper discusses the role of the nuclear factor-E2 p45-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway in combating excess oxidative stress in diabetes.
The role of NRF2 in diabetes is to regulate redox balance in cells and activate antioxidant enzymes, which helps to dampen inflammation and oxidative damage in diabetic complications.

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