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What is the role of sirtuin7 homeostasis in regulating the receptor protein TβR1?

Bone remodeling

Calorie restriction

Glucose homeostasis

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Sirtuin7 (SIRT7) plays a role in regulating the receptor protein TβR1 .

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Journal Article•DOI SIRT1 Regulation in Ageing and Obesity. Patricia S. Pardo, Aladin M. Boriek - Show less +1 more 19 Apr 2020-Mechanisms of Ageing and Development 32 Citations	The provided paper does not mention anything about the role of sirtuin7 homeostasis in regulating the receptor protein TβR1.
Open access•Journal Article•DOI SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1 Nicolas G. Simonet, Joshua K. Thackray, Berta N. Vazquez, Alessandro Ianni, Maria Espinosa-Alcantud, Julia Morales-Sanfrutos, Sarah Hurtado-Bagès, Eduard Sabidó, Marcus Buschbeck, Jay A. Tischfield, Carolina De La Torre, Manel Esteller, Thomas Braun, Mireia Olivella, Lourdes Serrano, Lourdes Serrano, Alejandro Vaquero - Show less +16 more 01 Jul 2020-Science Advances 21 Citations	The provided paper does not mention anything about the role of sirtuin7 homeostasis in regulating the receptor protein TβR1.
Open access•Journal Article•DOI Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis Qiangqiang Li, Jack C. Y. Cheng, Qing Jiang, Wayne Yuk-Wai Lee - Show less +3 more 04 Jan 2021-Aging Cell 17 Citations	The provided paper does not mention the role of sirtuin7 homeostasis in regulating the receptor protein TβR1.
Journal Article•DOI A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism. Shahab Shahgaldi, Fatemeh Rezaei Kahmini - Show less +1 more 01 Oct 2021-Life Sciences 25 Citations	The provided paper does not mention the role of sirtuin7 homeostasis in regulating the receptor protein TβR1.

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What are the mechanisms by which mechanical homeostasis is regulated?5 answersMechanical homeostasis is regulated through various mechanisms. Negative feedback loops are activated when there are deviations from the optimal range, helping to return the system to the correct range. MicroRNAs (miRNAs) play a crucial role in maintaining mechanical homeostasis in different biological systems. Cells are sensitive to forces and convert mechanical stimuli into a chemical response through a phenomenon called mechanotransduction. Mechanotransduction is an integral part of cellular physiology and has a significant impact on organism development and homeostasis. Malfunctioning mechanical properties or mechanotransduction can lead to pathological conditions. Mechanotransduction is diverse and varies depending on cell type and environment. Mechanical forces are important in regulating tissue development and homeostasis in various cell types, and they are also implicated in the development of diseases. The activation of the Wnt signaling pathway is one of the mechanisms by which cells sense and respond to mechanical forces.

What are the potential therapeutic implications of targeting SIRT7 in cardiovascular diseases?5 answersTargeting SIRT7 in cardiovascular diseases has potential therapeutic implications. SIRT7 is involved in the regulation of cellular processes such as oxidative stress, inflammation, and metabolism, which are key factors in the development and progression of cardiovascular diseases. SIRT7 has been shown to play a role in cardiac hypertrophy, myocardial infarction, and heart failure, indicating its potential as a therapeutic target in these conditions. Additionally, SIRT7 has been implicated in the progression of various cardiovascular diseases, including heart failure, pulmonary hypertension, hypertension, and coronary atherosclerosis. Targeting SIRT7 activity and expression could lead to improvements in these disorders and provide new avenues for diagnosis and treatment. Further research is needed to fully understand the therapeutic implications of targeting SIRT7 in cardiovascular diseases and to develop specific SIRT7-targeted drugs.

What are the mechanisms by which Sirtuin 7 regulates cardiovascular diseases?3 answersSirtuin 7 (SIRT7) regulates cardiovascular diseases through various mechanisms. SIRT7 modulates senescence, DNA damage repair, ribosomal RNA synthesis, protein biosynthesis, angiogenesis, apoptosis, superoxide generation, cardiorenal metabolism, and dysfunction. It also plays a critical role in oxidative stress, inflammation response, endoplasmic reticulum stress, and mitochondrial homeostasis. SIRT7 is involved in cardiorenal hypertrophy, fibrosis, remodeling, heart failure, atherosclerosis, and renal acid-base and electrolyte homeostasis. Additionally, SIRT7 has been implicated in the prevention and treatment of cardiorenal diseases. The specific mechanisms by which SIRT7 regulates cardiovascular diseases are not mentioned in the abstracts provided.

What is the role of SIRT7 in cardiovascular diseases?4 answersSIRT7 plays a role in cardiovascular diseases by preventing endothelial senescence, which is believed to be the initial pathogenesis of atherosclerotic cardiovascular disease (ASCVD). It has been found that SIRT7 expression is decreased in human umbilical vein endothelial cells (HUVECs) exposed to risk factors such as high glucose, tumor necrosis factor-α (TNF-α), and H2O2, which induce cellular senescence. The down-regulation of SIRT7 expression in HUVECs can be attenuated by inhibiting the expression of microRNA-335-5p (miR-335-5p), which is significantly up-regulated in oxidative stress-induced endothelial cells. Furthermore, miR-335-5p has been shown to directly bind to SIRT7, leading to its down-regulation in human cells. These findings suggest that SIRT7 may be a potential therapeutic target for ASCVD and other age-related diseases.

How does activation of Sirtuin 7 affect the aging process?4 answersActivation of Sirtuin 7 (SIRT7) affects the aging process by regulating cellular activities and maintaining chromatin architecture. SIRT7 expression declines during aging, and its deficiency accelerates senescence in human mesenchymal stem cells (hMSCs). SIRT7 forms a complex with nuclear lamina proteins and heterochromatin proteins, maintaining the repressive state of heterochromatin at the nuclear periphery. Loss of SIRT7 leads to loss of heterochromatin, de-repression of retrotransposons, and activation of innate immune signaling via the cGAS-STING pathway. Activation of SIRT7 can reverse these aging-associated defects by restoring heterochromatin and inhibiting retrotransposon activity. Therefore, SIRT7 plays a crucial role in safeguarding chromatin architecture and controlling innate immune regulation during stem cell aging.

What is the structure of Sirtuin 7?3 answersسيرتوين 7 (SIRT7) هو عضو في عائلة بروتينات السرتوين. يحتوي على مجال أساسي تحفيزي ثابت للغاية مسؤول عن نشاطه الأنزيمي. المناطق الطرفية N و C في SIRT7 متباينة هيكليًا، مما يؤدي إلى اختلافات في التوطين تحت الخلوي والنشاط الأنزيمي وخصوصية الركيزة. يوجد SIRT7 بشكل أساسي في النواة.

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