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What is the target of rheumatoid factors ? 

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Rheumatoid factors (RFs) target the Fc region of immunoglobulin G (IgG) .

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Open accessJournal ArticleDOI
13 Nov 2013-Disease Markers
198 Citations
The target of rheumatoid factors is the Fc region of immunoglobulin G (IgG).
Book ChapterDOI
01 Jan 2007
1 Citations
The target of rheumatoid factors (RFs) is the constant regions of the heavy chain in the IgG Fc fragment.
The target of rheumatoid factors (RFs) is the Fc region of immunoglobulin (Ig)G.
The paper does not mention the specific target of rheumatoid factors. The paper discusses various targets for biologic therapies in rheumatoid arthritis, including cytokines, adipokines, and microparticles.
The target of rheumatoid factors (RFs) is the Fc region of IgG.

Related Questions

What are the national priorities for research on risk factors associated with the development of rheumatoid arthritis?5 answersCurrently, there is an increasing interest in treating patients at risk of rheumatoid arthritis (RA) to prevent the development of this chronic disease. The early identification of predictive factors for RA is crucial, including autoantibodies, markers of systemic inflammation, and clinical features such as articular affection and patient's clinical perception. Additionally, sociodemographic and environmental factors, such as lifestyle habits and periodontal disease, are also being considered as potential risk factors for RA. Furthermore, there is a need to investigate the role of cardiovascular disease (CVD) risk factors in RA outcomes. Low social support and low decision latitude at work have also been associated with an increased risk of RA. Sleep disorders (SDs) have been found to be associated with an increased risk of RA, particularly sleep apnea. Overall, the national priorities for research on risk factors associated with the development of RA include early identification of predictive factors, understanding the role of sociodemographic and environmental factors, investigating the impact of CVD risk factors, and exploring the association between sleep disorders and RA.
What are the most effective treatments for rheumatoid arthritis research articles?5 answersThe most effective treatments for rheumatoid arthritis (RA) include traditional anti-rheumatic drugs, biological agents, and disease-modifying antirheumatic drugs (DMARDs). Biological agents, such as inhibitors of tumor necrosis factor (TNF)-α and interleukin-1, have shown significant advantages in recent years and are widely used. DMARDs, including methotrexate, hydroxychloroquine, sulfasalazine, and leflunomide, are considered first-line therapy for newly diagnosed cases of RA. Additionally, targeted synthetic DMARDs and small molecule anti-rheumatic drugs have also been successful in treating RA. Other potential treatments for RA include microbial therapy, tuned cationic dendrimer therapy, and alternative topical and naturally based options such as Aloe vera and Curcumin (turmeric). Overall, a combination of pharmacologic therapies, including DMARDs and biological agents, along with early aggressive therapy, has shown promising results in the effective treatment of RA.
What is Therapeutic targets for inflammatory bowel disease?5 answersTherapeutic targets for inflammatory bowel disease (IBD) include proteins such as MST1, HGFAC, STAT3, ITPKA, and CXCL5. Polyphenols, a group of phytochemicals, have also shown potential as therapeutic targets for IBD due to their anti-inflammatory and antioxidant effects, as well as their ability to modulate the gut microbiome. In addition, the management of rare and extraordinary rare causes of non-variceal upper gastrointestinal bleeding (NVUGIB) is an important therapeutic target in IBD. The interorgan networks and molecular networks in immune cells are also potential therapeutic targets for IBD. Furthermore, transient receptor potential (TRP) channels in the gastrointestinal tract have been implicated as potential drug targets for IBD.
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What are the inflammatory factors related to B cells?5 answersB cells are associated with the production of inflammatory factors such as TNFα and IL-6. B cells can also produce proinflammatory cytokines like TNFa and IL-6 through B-cell receptor (BCR) ligation, binding of the costimulatory ligand on activated T-cells, or interaction with circulating cytokines. Additionally, B cells have been found to contribute to neurological diseases through peripheral immune mechanisms, including the production of cytokines and antibodies. The role of B cells in inflammation is complex, as they can also have anti-inflammatory functions. For example, B cell activating factor (BAFF) has been shown to select IL-10-B cells over IL-10+ regulatory B cells in inflammatory responses. Further research is needed to fully understand the specific inflammatory factors and mechanisms associated with B cells in different contexts.
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