What is the role of interleukins in rheumatoid arthritis?5 answersInterleukins play a significant role in the pathogenesis of rheumatoid arthritis (RA) by contributing to joint inflammation, destruction of articular cartilage, and production of destructive enzymes. IL-4 and IL-13, members of the Th2 cytokine family, have been implicated in the development of autoimmune diseases and inflammatory arthritis, and they may downregulate inflammatory processes underlying RA pathology. Other interleukins such as IL-1, TNF-α, IL-6, IL-15, IL-17, and IL-18 are also involved in joint and cartilage destruction, inflammatory reactions, and comorbidities associated with RA. Blocking the activity of these biomarkers has shown successful treatment of RA. IL-23, another interleukin, plays a role in the development of RA by activating signaling pathways that lead to joint inflammation and destruction, mainly through IL-17 and Th17 cells. Monoclonal antibodies targeting IL-23 have been evaluated in clinical trials for RA treatment. Overall, interleukins contribute to the pathogenesis of RA through various mechanisms and targeting them may provide therapeutic benefits.
What are the potential therapeutic targets for KOA?5 answersThe potential therapeutic targets for knee osteoarthritis (KOA) include inhibition of tissue destruction, stimulation of natural repair processes, novel approaches to pain treatment, and addressing physical disability.
What are the most effective treatments for polyarticular arthritis?3 answersThe most effective treatments for polyarticular arthritis include nonsteroidal anti-inflammatory agents (NSAIDs), corticosteroids, disease modifying antirheumatic drugs (DMARDs) such as methotrexate (MTX), and biologic treatments. Biologic treatments, such as abatacept, adalimumab, etanercept, infliximab, and tocilizumab, have shown efficacy in managing polyarticular-course JIA (pcJIA) when used alone or in combination with MTX. Additionally, joint replacements have been employed to treat joint problems in patients with polyarticular arthritis, including rheumatoid arthritis (RA) and osteoarthritis. Early recognition and appropriate intervention are crucial in managing polyarticular septic arthritis (PASA) in patients with RA, as it is an emerging and difficult condition to manage. In the case of ochronotic arthropathy, prosthetic replacement, such as total knee arthroplasty and total hip arthroplasty, has been found to be an effective treatment option.
What are the protein targets of abrin?5 answersStep 1: Answer without citation
Abrin targets ribosomes, leading to inhibition of protein synthesis. It also induces apoptosis through caspase-dependent pathways, involving mitochondrial damage and reactive oxygen species production.
Step 2: Finding Citations
Step 3: Answer with citation
Abrin targets ribosomes, leading to inhibition of protein synthesis, as demonstrated by Wang et al.. Additionally, abrin induces apoptosis through caspase-dependent pathways, involving mitochondrial damage and reactive oxygen species production, as reported by Narayanan et al..
What is the target for inflammation mandated by the government?10 answers
What kind of CBD is good for rheumatoid arthritis?5 answers