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What is the target of the ACPA in rheumatoid arthritis? 

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Anti-citrullinated protein antibodies (ACPA) are the target in rheumatoid arthritis (RA) . ACPA are detectable in about two-thirds of RA patients and are used as a diagnostic criterion for the disease . These antibodies specifically target citrullinated proteins, which are proteins that have undergone a post-translational modification called citrullination . Citrullination is the conversion of the amino acid arginine to citrulline, and this modification is believed to play a role in the development and progression of RA . The presence of ACPA in the blood is associated with disease severity and is a major risk factor for RA progression . The specific targets of ACPA can vary between individuals, and the level of ACPA and their target cross-reactivity increase over time in RA patients .

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The paper does not provide information about the specific target of ACPA in rheumatoid arthritis.
The paper does not provide information about the specific target of the ACPA in rheumatoid arthritis.
The paper does not provide information about the specific target of ACPA in rheumatoid arthritis.
The paper does not provide information about the specific target of ACPA in rheumatoid arthritis.
The paper does not provide information about the specific target of ACPA in rheumatoid arthritis.

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