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What is the target of the ACPA in rheumatoid arthritis? 

Serology
Medicine
clone (Java method)
Arthritis
B cell
Best insight from top research papers

Anti-citrullinated protein antibodies (ACPA) are the target in rheumatoid arthritis (RA) . ACPA are detectable in about two-thirds of RA patients and are used as a diagnostic criterion for the disease . These antibodies specifically target citrullinated proteins, which are proteins that have undergone a post-translational modification called citrullination . Citrullination is the conversion of the amino acid arginine to citrulline, and this modification is believed to play a role in the development and progression of RA . The presence of ACPA in the blood is associated with disease severity and is a major risk factor for RA progression . The specific targets of ACPA can vary between individuals, and the level of ACPA and their target cross-reactivity increase over time in RA patients .

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Papers (5)Insight
Open access•Journal Article•DOI
Patients with ACPA-positive and ACPA-negative rheumatoid arthritis show different serological autoantibody repertoires and autoantibody associations with disease activity
Wilfried Kuhn
01 Apr 2023-Dental science reports
1 Citations
The paper does not provide information about the specific target of ACPA in rheumatoid arthritis.
Open access•Posted Content•DOI
Divergent and dominant anti-inflammatory effects of patient-derived anti-citrullinated protein antibodies (ACPA) in arthritis development
Bruno Raposo, Vivianne Malmström 
01 Oct 2022
1 Citations
The paper does not provide information about the specific target of the ACPA in rheumatoid arthritis.
Open access•Journal Article•DOI
Divergent and dominant anti-inflammatory effects of patient-derived anticitrullinated protein antibodies (ACPA) in arthritis development
Bruno Raposo, Marcelo Afonso, Lena Israelsson, Heidi Wähämaa, Ragnhild Stålesen, Fredrik Wermeling, Caroline Grönwall, Bence Rethi, Lars Klareskog, Vivianne Malmström 
27 Nov 2022-Annals of the Rheumatic Diseases
3 Citations
The paper does not provide information about the specific target of ACPA in rheumatoid arthritis.
Open access•Journal Article•DOI
Op0185 immunophenotypic abnormalities reminiscent of established rheumatoid arthritis are present in acpa(+) at-risk individuals
Mary Beth Gillespie, Z He, Samir Rachid Zaim, Lauren Y. Okada, Jacob Reading, Alexander T Heubeck, C. Roll, Palak C Genge, Morgan Da Weiss, C. A. Phalen, R Mettey, Cate Speake, J.M. Buckner, D. Boyle, Kristen Demoruelle, Kristine A. Kuhn, F. Zhang, Thomas F. Bumol, V. Michael Holers, Peter J Skene, Gs Firestein, Troy Torgerson, K. Deane, Adam K. Savage 
30 May 2023-Annals of the Rheumatic Diseases
The paper does not provide information about the specific target of ACPA in rheumatoid arthritis.
Journal Article•DOI
Pos1036 nf-κb signalling is critically important for functional responses of acpa-producing b cell clones from patients with rheumatoid arthritis
G. Frazzei, Youngna Kan, J. P. van Hamburg, R. van Vollenhoven, S. Tas 
30 May 2023-Annals of the Rheumatic Diseases
The paper does not provide information about the specific target of ACPA in rheumatoid arthritis.

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