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The novel COVID-19 has an affinity for ACE-2 receptors.
We find the gut as the putative hotspot of COVID-19, where a maturation correlated transcriptional signature is shared in small intestine enterocytes among coronavirus receptors (ACE2, DPP4, ANPEP).
This study demonstrates that Dex could bind to both the viral and host receptors as a potential drug candidate for COVID-19.
Based on these results, we suggest that severe COVID-19 symptoms may be determined by differential expression of glucocorticoid receptors and neutrophils.
Our data suggest that more research is needed to determine the effect of different medications, as well as medication combinations, on COVID-19 receptors.
We propose that blocking the B1 and B2 receptors might have an ameliorating effect on disease caused by COVID-19.
Restoring lipoprotein function with ApoA‐I raising agents or blocking relevant scavenger receptors with neutralizing antibodies could, therefore, be of value in the treatment of COVID‐19.
These results indicate that (i) Neu5,9Ac2 is the primary receptor determinant required for influenza C virus to attach to tissue culture cells and to initiate infection and (ii) gangliosides containing this type of sialic acid are potential receptors for influenza C virus.
These findings were consistent with what observed for mammalian virus receptors reported in previous studies, suggesting that viral protein receptors tend to have multiple interaction partners and high expressions.
Open accessJournal ArticleDOI
Sarah A. Nowak, Tom Chou 
29 Citations
In our model, receptors attach the cell membrane to the viral membrane, while subsequent binding of coreceptors enables fusion.

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