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These results demonstrate both structural and functional connections between grafts of spinal cord and skeletal muscle tissue in vivo.
This is because the mammalian spinal cord reacts to injury with only limited endogenous repair.
This may contribute to the lack of regeneration in the central nervous system after spinal cord injury.
Spinal cord mechanisms are possibly involved.

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Where are scaffold for neural tissues applied in?5 answersScaffolds for neural tissues are applied in various areas including peripheral nervous system (PNS) recovery, treatment of peripheral nerve injury, neural regeneration, tissue engineering, regenerative medicine, and drug discovery. These scaffolds, known as neural scaffolds, play a crucial role in promoting tissue regeneration and functional recovery by acting as carriers for transplanted peripheral nervous system cells or biological cues and providing structural support to direct growing nerve fibers towards the target area. They are composed of different biomaterials such as synthetic polymers, natural materials, extracellular matrix components, glass fabrics, ceramics, and metallic materials, which are fabricated to create specific structures and surface features. The scaffolds can be used in both 2D and 3D culture environments to guide neural growth and influence cell behavior. Additionally, they can be functionalized with bioactive signals, cytokines, growth factors, or biomolecules to enhance neural proliferation and cells-extracellular matrix interplay. Biomimetic nanofibrous scaffolds, created using techniques like 3D printing and microfluidics, are particularly suitable for neural tissue engineering due to their ability to mimic the in vivo cellular microenvironment.
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Recent research on NG2 glia has unveiled intriguing findings. Studies have shown that NG2 glia play a crucial role in various neurological conditions. Santini et al. demonstrated that in vivo reprogramming of NG2 glia leads to axonal regeneration and improved function after spinal cord injury. Liu et al. highlighted the protective effect of NG2 glia in prion infections and the role of prostaglandin E2 signaling. Miralles et al. focused on the role of GPR17-expressing NG2 glia under physiological conditions, suggesting a distinct function beyond classic differentiation control. Janeckova et al. investigated the heterogeneity of NG2 glia after ischemic injury, revealing their neurogenic potential and differentiation plasticity. Timmermann et al. found that dysfunctional NG2 glia impact neuronal signaling and behavior, emphasizing the importance of proper NG2 glia function for normal brain function.