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These data suggest that acute treatment of estrogen may have a biphasic action on the pituitary PRL section and that the augmentatory effect of estrogen on PRL secretion is dose-dependent in human beings.
It appears that there exist both time and dose thresholds for effective enhancement of prolactin secretion by estrogen.
In other anovulatory cycles, follicular-phase estrogen levels did not lower LH secretion as occurs in cycles of younger women, indicating decreased estrogen-negative feedback on LH secretion.
Furthermore, we speculate that any stimulatory role of androgens on GH secretion is exerted primarily through the estrogen receptor after aromatization.
We speculate that the augmentation of GH secretion observed during antagonism of androgen action in late pubertal males is a result of increased stimulation of estrogen receptor-mediated pathways.
Although much work has been done on the effect of estrogen upon the amount of hormone within the gland, this may not always be a valid index of the secretion rate of the hormone.
Journal ArticleDOI
R. X.-D. Song, Richard J. Santen 
01 Jan 2003-Apoptosis
109 Citations
The effects of estrogen are estrogen-receptor dependent.
Moreover, the results indicate that the same groups of cells can be used on consecutive days to investigate the inhibitory and stimulatory effects of estrogen on LH secretion.
Furthermore, these results demonstrate that FSH secretion is not under the control of estradiol whereas LH secretion is under feedback control of ovarian estrogen.

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