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When will stem cell treatment be available for periodontal disease? 

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So it is speculated that botanical products may become a new perspective in stem cell-based periodontal regeneration.

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What are the current advancements in stem cell technology for wound healing?5 answersRecent advancements in stem cell technology for wound healing include the use of induced pluripotent stem cells (iPSCs) to generate personalized three-dimensional skin constructs for disease modeling and autologous grafts. Adipose stem cell matrix gel, derived from adipose tissue, has been shown to effectively promote wound healing by regulating inflammatory reactions, promoting microvascular reconstruction, and collagen synthesis. Hematopoietic stem cells (HSCs) have also been found to play a critical role in wound healing, with myeloid cells derived from HSCs being important for the process. In situ cell electrospinning, a novel approach for stem cell delivery, has been developed to enhance the efficacy of stem cell therapy for cutaneous wound healing. Additionally, mesenchymal stem cell-derived extracellular vesicles (EVs) have shown promise in promoting wound healing by eliminating infections, inhibiting inflammation, promoting angiogenesis, and reducing scar formation.
Why are stem cells not used to treat autoimmune disease?4 answersStem cells are not widely used to treat autoimmune diseases due to several reasons. Firstly, while stem cells have shown potential in reducing immune-mediated damage and regulating the immune system, the clinical outcomes of stem cell-based therapies have been variable and inconsistent, highlighting the need for more robust preclinical models and better prediction of therapeutic benefits. Secondly, hematopoietic stem cell transplantation (HCT) has shown efficacy in certain autoimmune diseases such as multiple sclerosis (MS) and systemic sclerosis (SSc), but large comparative trials are still needed for diseases like lupus. Additionally, the use of mesenchymal stem cells (MSCs) in autoimmune diseases has shown promise, but there is still a need for more clinical trials and treatment algorithms to determine their efficacy and safety, especially in children. Furthermore, the clinical heterogeneity of autoimmune diseases and the challenges in optimizing patient selection and minimizing side effects also contribute to the limited use of stem cells in treating autoimmune diseases.
What are the applications of AI in periodontal disease?4 answersArtificial intelligence (AI) has shown promise in various applications in the field of medicine, but there is limited literature on its applications in periodontal disease. However, AI has been widely used in clinical medicine and has the potential to aid in the analysis of periodontal disease. AI can be used for image analysis, lesion determination, and healthcare management, which can contribute to the diagnosis and treatment of periodontal disease. Additionally, AI methodologies such as machine learning and deep learning have been applied in the field of pancreatobiliary diseases, which require complex diagnosis and treatment decisions. Although there is limited research specifically on AI applications in periodontal disease, the use of AI in healthcare and related fields suggests its potential for aiding in the analysis and management of periodontal disease.
What is the effect of stem cells on bone regeneration?5 answersStem cells have shown to be effective in bone regeneration. They can be used for the treatment of various bone-related diseases and have been found to be more efficient than traditional methods such as surgical procedures. Stem cell-based therapy combined with bone tissue engineering is a possible alternative to current bone augmentation techniques. Stem cells have self-renewal and differentiation capacity, and they can secrete bioactive molecules and regulate the behavior of other cells in the host tissue, which can improve the bone regeneration process. Stem cells, including multipotent and pluripotent cells, are considered a regenerative remedy for bone defects. Transplantation of mesenchymal stem cells (MSCs) has been investigated for bone regeneration, but engraftment of transplanted cells can be hindered by insufficient oxygen and nutrients supply. Various approaches, such as scaffold and hydrogel constructs, genetic modifications, and surface engineering of the cell membrane, are being explored to improve MSCs transplantation for bone regeneration.
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