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Where are estrogen and testosterone produced? 

Testosterone
Aromatase
Estrogen
Estrone
Dihydrotestosterone

Answers from top 14 papers

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Papers (14)Insight
Open access•Journal Article•DOI
Sexual differentiation of aromatase activity in the rat brain: effects of perinatal steroid exposure.
Charles E. Roselli, Scott A. Klosterman 
01 Jul 1998-Endocrinology
105 Citations
The process that differentiates aromatase expression appears to depend on androgen exposure and, in part, local estrogen synthesis, as diethylstilbestrol was able to substitute for testosterone propionate.
Journal Article•DOI
The histochemistry of estrogen receptors.
Sin Hang Lee
01 Jan 1981-Histochemistry and Cell Biology
28 Citations
Thus their binding behavior and distribution pattern are consistent with those of specific estrogen receptors.
Journal Article•DOI
The development of estrogen receptor systems in the rat brain and pituitary: postnatal development.
Neil J. MacLusky, Claude Chaptal, Bruce S. McEwen 
07 Dec 1979-Brain Research
181 Citations
The possibility is discussed that this estrogen arises from testosterone via aromatization.
Journal Article•DOI
Transformation de la dehydroépiandrosterone 4-14C par les gonades embryonnaires de la caille japonaise (Coturnix coturnix japonica) explantées in vitro
D. Scheib, K. Haffen, Arlette Guichard, Lise Cedard 
01 Aug 1974-General and Comparative Endocrinology
In the latter species, estrogens are chiefly produced by female gonads, and testosterone is formed in larger relative amounts by embryonic testis.
Journal Article•DOI
Sex steroid hormones during multiphase pubertal developments.
Derek Gupta, K. Rager, A. Attanasio, W. Klemm, M. Eichner 
01 Jun 1975-Journal of Steroid Biochemistry
Estradiol levels in boys were highly correlated to testosterone concentrations, indicating that perhaps a significant portion of the estrogen is derived from circulating androgens.
Journal Article•DOI
Effect of gonadectomy and gonadal hormones on singly established Hymenolepis diminuta in rats
J.Walter Beck
01 Mar 1952-Experimental Parasitology
44 Citations
A stimulation of testosterone production is postulated as a possible mechanism in the case of normal male rats and possibly the production of estrogen in the normal female hosts.
Journal Article•DOI
Aromatase expression in the human breast
Angela Brodie, Brian J. Long, Qing Lu 
01 Jan 1998-Breast Cancer Research and Treatment
51 Citations
The findings suggests that estrogen produced locally is important in enhancing proliferation of the tumor.
Journal Article•DOI
Hormonal changes in puberty.
Allen W Root
01 Oct 1980-Pediatric Annals
85 Citations
Peripheral aromatase conversion of testosterone to estrogen, especially by fatty tissue, is possible, and is
Journal Article•DOI
Estrogen synthesis in normal and hypogonadal men: quantitative studies on the precursor role of testosterone
B. J. Epstein, M. C. Raheja, E. Frow, W. I. Morse 
01 Jun 1966-Biochemistry and Cell Biology
19 Citations
The specific activities of the urinary estrogen fractions from the normal men were sufficiently low to warrant the conclusion that there were other sources of estrogen production in addition to the plasma testosterone pool.
Journal Article•DOI
Age, estrogen, and the endometrium.
James Aiman
01 Mar 1981-Clinical Obstetrics and Gynecology
Second, the estrogen produced by these women is biologically active.
Journal Article•DOI
Androgen Metabolism in the Brain of the Green Anole Lizard (Anolis carolinensis)
Juli Wade
01 Apr 1997-General and Comparative Endocrinology
33 Citations
These results suggest roles for both aromatase (which catalyzes the conversion of testosterone to estradiol) and 5 alpha-reductase (which converts testosterone to dihydrotestosterone).
Journal Article•DOI
Aromatization of testosterone to estrogen varies between strains of mice.
Peter J. Sheridan, Robert T. Melgosa 
29 Aug 1983-Brain Research
The results suggest testosterone is aromatized to estrogen in n. preopticus medialis ventralis in the Swiss--Webster mouse.
Open access•Journal Article•DOI
Expression and localization of estrogenic type 12 17β-hydroxysteroid dehydrogenase in the cynomolgus monkey
Hong Liu, ShuFang Zheng, Véronique Bellemare, Georges Pelletier, Fernand Labrie, Van Luu-The 
05 Feb 2007-BMC Biochemistry
26 Citations
It strongly suggests that in the estradiol biosynthesis pathway, the step of 17-ketoreduction comes after the step of the aromatization (the aromatization of 4-androstendione to estrone followed by the conversion of estrone into estradiol by estrogen specific l7β-HSDs) which is in contrast with the hypothesis suggesting that 4-androstenedione is converted to testosterone followed by the aromatization of testosterone.
Journal Article•DOI
Androgen biosynthesis in the quail brain
Masahiro Matsunaga, Kazuyoshi Ukena, Kazuyoshi Tsutsui 
06 Sep 2002-Brain Research
55 Citations
Testosterone may subsequently be converted to estradiol.

Related Questions

Can skin synthesize estrogen?5 answersYes, skin has the capability to synthesize estrogen locally. Research indicates that human skin cells, particularly epidermal keratinocytes and melanocytes, express enzymes involved in estrogen synthesis, such as 17β-hydroxysteroid dehydrogenase 1 (HSD17β1). This local estrogen production plays a crucial role in protecting skin cells from oxidative stress and promoting cell survival. Additionally, skin fibroblasts and keratinocytes have been found to express key steroidogenic proteins and estrogen receptors, enabling the intracrine production of active sex steroid hormones like estrogen from adrenal precursors. Furthermore, studies have shown that estrogen, specifically 17β-estradiol, can stimulate the synthesis of connective tissue components in the skin, highlighting the regulatory role of estrogen in skin health and repair.
Where is parathyroid hormone produced?5 answersParathyroid hormone (PTH) is produced by the parathyroid glands, which are located adjacent and behind the thyroid gland. The parathyroid glands continuously regulate serum calcium levels by secreting PTH in response to low calcium levels in the blood. PTH plays a crucial role in maintaining calcium and phosphate homeostasis in the body. It acts on various organs, including the bones, kidneys, and small intestines, to regulate calcium and phosphate levels. PTH secretion is tightly regulated through a negative-feedback loop, where increased calcium levels in the blood suppress PTH release. PTHrP, a related peptide, is also involved in calcium regulation but is expressed in most tissues of the body and acts locally as a paracrine/autocrine factor.
How is testosterone produced in the body?5 answersTestosterone is produced in the body through a series of enzymatic reactions starting with the synthesis of cholesterol. There are multiple pathways for testosterone synthesis, including the "frontdoor" pathway and the "backdoor" pathways. The production of testosterone involves the translocation of cholesterol across the mitochondrial membrane and its conversion into testosterone. Testosterone is primarily produced in the Leydig cells of the testes, but it is also produced in the adrenal cortex, liver, kidneys, fat, and muscle tissue. The production and secretion of testosterone are regulated by the hypothalamus, pituitary gland, and testes. Testosterone can also be converted into other metabolites, such as estradiol and dihydrotestosterone, which have their own physiological effects.
How much estrogen is produced by ovaries?5 answers
What gland is responsible for estrogen?4 answers
Where is estrogen hormone produced?5 answers

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