scispace - formally typeset
Search or ask a question

Which assessment finding would a health care provider recognize as evidence of a paraneoplastic syndrome in an individual receiving radiation therapy for metastatic cancer? 

Answers from top 10 papers

More filters
Papers (10)Insight
Recognition of paraneoplastic syndromes is important, as it may lead to an early diagnosis of cancer.
There was also uptake by a sacral tumour, suggesting a diagnosis of paraneoplastic syndrome.
Recognition of this paraneoplastic syndrome may forewarn the physician of an underlying breast malignancy.
An elevated tumor marker in a patient with a presumed paraneoplastic neurologic disorder should suffice as evidence of an occult neoplasm, and guide definitive treatment.
Early recognition can lead to effective treatment of a paraneoplastic syndrome and a potential cure of the underlying cancer.
Some syndromes are associated with serum markers that are readily detectable and demonstration of these putative markers within prostate cancer tissue at an individual level would firmly link the paraneoplastic syndrome with its underlying prostatic malignancy.
It is pointed out that a paraneoplastic syndrome should always lead to a careful investigation for cancer.
A paraneoplastic syndrome may be the first sign of a malignancy so its recognition may be critical for early cancer detection.
Journal ArticleDOI
Lydia Sharp, Steven Vernino 
01 Dec 2012-Muscle & Nerve
23 Citations
Learning to recognize paraneoplastic neuromuscular disorders, the associated antibodies and their implications, and the appropriate screening modalities can, in some cases, lead to an earlier diagnosis of cancer.
The initial evaluation of the patient with known or suspected lung cancer should include an assessment of symptoms, signs, and laboratory test results in a standardized manner as a screen for identifying those patients with paraneoplastic syndromes and a higher likelihood of metastatic disease.

Related Questions

What are the psicological tests used to evaluate psilocybin assisted psychotherapy in cancer patients?4 answersPsilocybin-assisted psychotherapy for cancer patients has been evaluated using various psychological tests. The studies have used measures such as the Montgomery Asberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating Scale (HAM-A) to assess depression and anxiety severity. Qualitative methods, such as semistructured interviews and interpretative phenomenological analysis, have also been employed to understand patient experiences and psychological mechanisms of action. Additionally, self, community, and clinician reports have been used as subjective outcome measures to evaluate the effects of psilocybin on psychological distress. The studies have focused on assessing the impact of psilocybin on symptoms of anxiety, depression, and existential concerns, as well as attitudes toward disease progression, death, and spirituality.
Infertility diagnosis and radiation risks assessment?4 answersHysterosalpingography (HSG) is a commonly used diagnostic method for evaluating female infertility. It involves exposing patients to ionizing radiation, which raises concerns about radiation risks. Several studies have assessed the radiation dose and associated risks of HSG procedures. The mean entrance surface dose (ESD) ranged from 3.60 to 34.24 mGy, with corresponding effective doses ranging from 1.24 to 2.53 mSv. The estimated risks for cancer and hereditary effects were 24 x 10^-6 and 3.4 x 10^-6, respectively. However, these risks were considered comparable to natural incidence rates and were generally within international standards. CT-VHSG, a computerized tomography-based technique, was found to have high diagnostic performance and a lower radiation dose compared to conventional HSG. Overall, while radiation risks should be considered, HSG procedures can be considered safe when performed with optimized protocols and adherence to radiation protection guidelines.
What are the anxiety levels of cancer patients when being confronted with treatment options?\?5 answersAnxiety levels of cancer patients when being confronted with treatment options vary depending on the stage of treatment and specific procedures. Patients who appeared for tumor board decision showed the highest state-anxiety levels, followed by patients undergoing surgery. Patients already undergoing chemotherapy had lower state-anxiety levels than other patients. Patients undergoing chemotherapy also showed lower anxiety levels relating to many procedures of breast cancer treatment. In more advanced stages of cancer, patients were more likely to have higher levels of anxiety. It is important to provide psychological support to patients in the early stage of cancer detection and when metastases form. A strong patient-healthcare provider relationship after diagnosis may help reduce distress among patients with higher levels of medical mistrust.
What are the most common functional assessments used for cancer patients that receiving chemotherapy?3 answersThe most common functional assessments used for cancer patients receiving chemotherapy include the Nutrition Risk Screening (NRS) 2002, the Functional Assessment of Anorexia/Cachexia Therapy (FAACT), and the Eastern Cooperative Oncology Group (ECOG) criteria. The NRS 2002 is used to assess the risk of malnutrition in cancer patients undergoing chemotherapy. The FAACT is used to determine the functional status of cancer patients, specifically in relation to anorexia and cachexia. The ECOG criteria are widely used to evaluate a patient's performance status, which is an important factor in determining treatment options for cancer patients. These assessments help healthcare professionals understand the nutritional and functional status of cancer patients undergoing chemotherapy, allowing for better care and treatment decisions.
Why pain assessment is important in cancer patient?4 answersPain assessment is important in cancer patients because it allows for proper recognition and understanding of the type and severity of pain experienced, which is crucial for effective pain management. Cancer pain can be complex and heterogeneous, with multiple contributing factors, and can have a significant impact on various aspects of a patient's life. By assessing pain, healthcare professionals can tailor treatment strategies to target specific pain mechanisms, such as nociceptive, neuropathic, nociplastic, or mixed pain, leading to better pain control. Additionally, pain assessment helps in identifying the underlying cause of pain, which can guide the selection of appropriate pharmacological and non-pharmacological interventions. Understanding the patient's pain experience also allows for a holistic approach to care, addressing not only the physical aspects but also the psychological, social, and spiritual dimensions of pain. Overall, pain assessment plays a crucial role in improving the quality of life for cancer patients by facilitating personalized and multimodal pain management.
Assessments for patient Cushing's syndrome?3 answersAssessments for Cushing's syndrome include various screening tests and diagnostic procedures. Initial workup should begin with excluding local and systemic corticosteroid use. First-line screening tests include the 1-mg dexamethasone suppression test, 24-hour urinary free cortisol excretion, and late-night salivary cortisol measurement. In addition, scalp-hair cortisol/cortisone analysis can help assess long-term glucocorticoid exposure and detect transient periods of hypercortisolism. Once endogenous Cushing syndrome is established, measurement of plasma ACTH concentrations can differentiate between ACTH-dependent and ACTH-independent causes. Further assessment may involve different imaging modalities and dynamic biochemical testing, such as bilateral inferior petrosal sinus sampling, to pinpoint the cause of Cushing's syndrome. Ophthalmologic evaluation, including Enhanced-Depth Imaging (EDI)-Optical Coherence Tomography (OCT), can detect chorioretinal abnormalities in patients with Cushing syndrome. The drawing test can also be used to assess perceptions of patients about their disease and its relation to illness perceptions, quality of life, and clinical disease severity. Communication between physicians and patients is crucial for providing sufficient information and improving health-related quality of life during recovery.

See what other people are reading

What Are the Different Types of Sports?
4 answers
Various types of sports can be classified based on different criteria. One way to categorize sports is by the specific activities involved, such as Pool Exercise, Indoor Exercise, Road Exercise, Space Free Exercise, Indoor Sport, Field Sport, Summer Leisure, Winter Leisure, Golf, and Park-golf. Another classification method is based on the impact of exercise components on performance and cardiovascular adaptation, such as static (strength-related) and dynamic (endurance-related) exercise components. Additionally, sports can be differentiated by the skills required, such as outdoor and indoor skills, which can influence athletes' motivations and personality traits. Understanding these classifications can help in developing and promoting various sporting events and activities internationally.
How does the duration of intensive hemodialysis affect the incidence and severity of treatment complications?
4 answers
The duration of intensive hemodialysis can significantly impact the occurrence and severity of treatment complications. Research indicates that patients undergoing hemodialysis may experience various complications, including cardiovascular issues, infections, neurological manifestations, and nutritional challenges. Studies have shown that prolonged hemodialysis duration is associated with a higher incidence of major adverse cardiovascular events, sudden cardiac death, and protein-energy wasting. Additionally, the use of medications like anti-platelets and anticoagulants can influence the patency of arteriovenous fistulas, affecting the longevity of vascular access for hemodialysis. Therefore, optimizing the duration and management of hemodialysis, along with tailored medication regimens, is crucial in mitigating complications and improving patient outcomes.
What is the relationship between cholesterol homeostasis and TP53 mutation in terms of cardiovascular disease risk?
5 answers
Mutations in the TP53 gene, known for its tumor suppression role, have been linked to altered lipid metabolism, impacting cholesterol homeostasis. Specifically, individuals with left main coronary artery disease (LM-CAD) showed lower frequencies of the protective Arg/Arg genotype of TP53, potentially indicating reduced protection against atherosclerosis. Furthermore, bioinformatic analysis suggests that p53 may play a significant role in cardiovascular diseases, including CVD, potentially through interactions with hypoxia and lupus, although further experimental studies are needed to confirm these associations. These findings highlight the intricate relationship between TP53 mutations, lipid metabolism, and cardiovascular disease risk, emphasizing the importance of understanding the molecular mechanisms underlying these connections for potential therapeutic interventions.
What are the most common causative agents of fungal diseases in humans?
5 answers
The most common causative agents of fungal diseases in humans include Candida spp., Aspergillus spp., Cryptococcus spp., Pneumocytis spp., and Histoplasma. Candida species primarily affect individuals with compromised immune systems, requiring Th1-type cell-mediated immunity for clearance. Aspergillus species, especially A. flavus and A. fumigatus, are prevalent pathogens, with A. flavus producing aflatoxins that can contaminate food. Cryptococcus neoformans and C. gattii are significant human pathogens, causing severe meningitis and infections in immunocompromised individuals. Additionally, Histoplasma and Talaromyces, associated with wildlife, pose lethal systemic infections in immunocompromised patients. These fungal pathogens contribute to over 1.6 million annual deaths globally, affecting millions of individuals and posing a substantial public health challenge.
What is breast cancer?
5 answers
Breast cancer is a prevalent malignancy in women, arising from various cell types within the breast. It is characterized by abnormal cell growth that can spread to surrounding tissues and other parts of the body. The disease is categorized based on tumor size and metastasis status, with various treatment options available, including FDA-approved drugs with specific mechanisms of action. Breast cancer is a significant health concern globally, being the most common cancer in women and a leading cause of cancer-related deaths. The incidence of breast cancer has been on the rise in recent years, emphasizing the importance of prevention, early diagnosis, and effective treatment strategies to combat this disease.
Ultrasound Guided Fine-Needle Aspiration Biopsy Granulomatous lymphadenitis pediatric patient?
4 answers
Ultrasound-guided fine-needle aspiration biopsy (FNAB) is a valuable tool for diagnosing lymphadenopathies in pediatric patients. Studies have shown that FNAB is effective in differentiating between benign and malignant lymphadenopathies, aiding in appropriate treatment decisions. Additionally, percutaneous imaging-guided core needle biopsies (CNBs) have gained interest in pediatric oncology due to their high diagnostic accuracy and safety profile. CNBs have shown a high sensitivity and specificity in diagnosing malignancies in pediatric patients, with a low rate of complications. Overall, ultrasound-guided FNAB and CNBs play crucial roles in accurately diagnosing lymphadenopathies in pediatric patients, guiding treatment decisions, and ensuring timely initiation of appropriate therapies.
Granulomatous lymphadenitis and pulmonary tuberculosis?
5 answers
Granulomatous lymphadenitis is a common feature in both pulmonary tuberculosis (PTB) and tuberculous lymphadenitis (TBL). In PTB, angiogenic factors like VEGF and Ang play a role in granuloma formation. TBL, the most common form of extrapulmonary TB, often presents with tuberculous lymphadenitis, showing central caseous necrosis associated with lymphocyte density. Endobronchial ultrasound-guided biopsy aids in diagnosing granulomatous lymphadenitis, which can be a precursor to malignancies. Additionally, on chest CT scans, granulomatous lymphadenitis in the inferior pulmonary ligament can mimic lung lesions. Understanding the relationship between granulomatous lymphadenitis and TB is crucial for accurate diagnosis and management of these conditions.
Why are Muslims need to follow certain dietary restrictions?
5 answers
Muslims are required to adhere to specific dietary restrictions due to the significant role of food in human health and well-being. Islamic teachings, based on the Qur'an and hadith, emphasize the importance of consuming permissible foods to purify the body and soul, promoting overall health and preventing various ailments. Religious traditions, including fasting and dietary laws, play a crucial role in guiding lifestyle choices and promoting well-being within Islamic culture. Similarly, dietary constraints outlined in scriptures for Jews and Muslims highlight the importance of consuming beneficial foods for growth and health, as choices directly impact human well-being. These restrictions are not only religious obligations but also contribute to reducing the risk of chronic diseases, ultimately affecting life expectancy in older individuals.
Why are Muslims need to follow certain dietary restrictions? 2019 above?
5 answers
Muslims need to adhere to specific dietary restrictions due to the significant emphasis placed on food consumption in Islam, aiming at purifying the body and soul while providing guidance for optimal health and well-being. These dietary regulations are rooted in religious traditions that view diet as a crucial element of overall well-being, with fasting and abstinence being common practices across various faiths. The scriptures of Islam and Judaism provide guidelines on permissible and forbidden foods, highlighting the importance of consuming what benefits human health and avoiding what poses risks. Additionally, religious dietary habits can impact chronic diseases like cardiovascular issues and diabetes, influencing life expectancy, especially in older individuals. The observance of Islamic dietary laws also serves as a marker of integration for Muslim communities in non-Muslim-majority countries like Spain.
What are the design principles for explainabel artificial intelligence?
5 answers
The design principles for explainable artificial intelligence (AI) encompass various aspects to enhance user understanding and acceptance. These principles include global explainability, local explainability, personalized interface design, and consideration of psychological/emotional factors. Additionally, the importance of incorporating explainability into the pre-processing stage, specifically in feature selection, has been highlighted as a crucial design requirement. The need for AI explanations to be comprehensive, interpretable, and well-designed to ensure user comprehension and trust is emphasized across the literature. By integrating these design principles, AI systems can address acceptance barriers, increase transparency, and ultimately enhance the usability and effectiveness of intelligent systems in various high-stakes domains.
Is ckd a contraindication for heart transplantation?
5 answers
Chronic kidney disease (CKD) is not an absolute contraindication for heart transplantation. The 2016 International Society for Heart Lung Transplantation guidelines suggest that severe chronic renal dysfunction (eGFR <30 mL/min/1.73 m2) can be considered a relative contraindication for heart transplantation alone. However, patients with advanced heart failure and concomitant CKD may benefit from combined heart-kidney transplantation (HKT) to improve overall survival and reduce the risk of heart allograft rejection. CKD, especially at stage ≥4 pre-heart transplantation, is associated with an increased risk of post-transplant malignancies, emphasizing the need for strategies to mitigate this risk. Therefore, while CKD poses challenges and considerations in heart transplantation, it is not an absolute barrier to the procedure.