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Taken together, this study suggests that topical formulations such as creams including SLNs with QNT3-18 might be appropriate carriers for skin whitening agents.
These results indicate that G. uralensis and G. glabra extracts, which have been used as whitening agent, could be applicable to functional cosmetic ingredient as a natural antioxidant.
Highest-evidence literatures showed that glutathione is not beneficial enough as a skin-whitening agent as it was only effective in some parts of the body and did not elicit long-lasting effects.
These results suggest that glyasperin C and glycyrrhisoflavone could be promising candidates in the design of skin-whitening agents.
are promising compounds that could be useful for treating hyperpigmentation as skin-whitening agents.

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What is properties of butyl resorcinol compare with other resorcinol derivative?
5 answers
Butyl resorcinol, compared to other resorcinol derivatives, exhibits unique properties. Resorcinol derivatives synthesized with various functional groups and alkyl chains showed promising effects on melanoma cells and tyrosinase activity, indicating potential skin whitening properties. Additionally, alkylresorcinols, including butyl resorcinol, have demonstrated antimicrobial properties and DNA cleaving abilities, suggesting a role as defensive agents in plants. Furthermore, the liquid phase alkylation of resorcinol with tert.-butyl alcohol over different catalysts resulted in the production of 4-tert.-butyl resorcinol and 4,6-di-tert.-butyl resorcinol, with modified montmorillonite-K10 showing significantly higher butylation activity compared to other catalysts. These findings highlight the diverse biological and chemical properties of butyl resorcinol in comparison to other resorcinol derivatives.
What is the benefit of Butyl resorcinol compare With whitening agent?
5 answers
Butyl resorcinol offers significant advantages over traditional whitening agents in terms of its inhibitory effects on melanin synthesis and enzyme activities. Research has shown that Butyl resorcinol effectively inhibits tyrosinase activity and melanin production in melanoma cells, making it a potent skin whitening agent. Additionally, Butyl resorcinol demonstrates stability in maintaining pH levels, brightening skin color, and providing sunscreen functions when combined with other compounds like hydroxyethyl piperazine ethane sulfonic acid and VC ethyl ether. Moreover, a derivative of Butyl resorcinol, peptide-4-n-butylresorcinol, has been developed to enhance the inhibitory effect on melanin synthesis, offering improved stability and reduced skin sensitivity. These findings collectively highlight the superior whitening and skin-beneficial properties of Butyl resorcinol compared to conventional whitening agents.
What are the recommended ice application times with open wounds?
5 answers
The optimal application window for ice on open wounds is within the immediate acute stage following injury to reduce secondary tissue damage proliferation. Ice packs have been shown to be effective in reducing postoperative pain in patients undergoing major abdominal operations, suggesting that ice application can aid in pain relief. However, using ice directly on burn wounds is not recommended, as studies indicate that cold tap water at approximately 15 degrees Celsius is beneficial for healing burn wounds, while ice should be avoided due to better outcomes with milder cooling techniques. Recent clinical studies have not found a strict time limit for closing traumatic wounds to avoid infection, indicating that many wounds can be closed later than the traditional six to eight-hour window without increased infection risk.
What is the most popular topic in pancreatic surgery recently?
5 answers
The most popular topic in pancreatic surgery recently is vascular resection, with 39 votes, followed by radical antegrade modular pancreatosplenectomy (RAMPS) versus standard distal pancreatectomy, celiac axis resection versus standard resection, spleen management in distal pancreatectomy, and the time point for surgery for chronic pancreatitis. Additionally, research in pancreatic surgery has evolved significantly, with a focus on complication management, surgical progress, and multimodal oncological treatment for pancreatic cancer. Furthermore, advancements in reducing postoperative pancreatic fistula rates have been reported, including the use of perioperative pasireotide, hydrocortisone therapy, and techniques like reinforcing the distal pancreatectomy suture/staple line and active drainage methods. These developments reflect the current trends and priorities in the field of pancreatic surgery.
Why does CBT assist with Adjustment disorder?
4 answers
Cognitive Behavioral Therapy (CBT) is beneficial for Adjustment Disorder (AjD) due to its effectiveness in reducing symptoms and improving coping mechanisms. Research has shown that internet-delivered CBT interventions, such as TAO, have been successful in treating AjD, leading to significant improvements in symptoms, post-traumatic growth, affect, and quality of life. Additionally, CBT combined with Positive Psychology strategies provides comprehensive support to individuals with AjD, enhancing their ability to overcome daily challenges. Furthermore, CBT protocols utilizing Virtual Reality (VR) have been designed to enhance patient adherence and engagement, ultimately improving treatment outcomes for AjD. Overall, CBT's structured approach, focus on cognitive restructuring, and incorporation of innovative technologies make it a valuable tool in addressing the symptoms and challenges associated with Adjustment Disorder.
How does CBT help migrants with adjustment disorder?
5 answers
Cognitive-behavioral therapy (CBT) has shown effectiveness in aiding migrants with adjustment disorder by providing structured support. CBT interventions, such as internet-delivered CBT programs, have been developed to specifically target adjustment disorder symptoms in migrants. These programs combine CBT techniques with Positive Psychology strategies to reduce clinical symptoms and enhance individuals' resilience in facing everyday challenges. The goal is to minimize distress symptoms associated with adjustment disorder and promote post-traumatic growth, positive affect, and an improved quality of life. By offering tailored support and evidence-based interventions like CBT, migrants experiencing adjustment disorder can effectively address their psychological distress and improve their overall well-being.
How effective are different therapeutic exercises in improving posture and reducing symptoms of upper crossed syndrome?
5 answers
Different therapeutic exercises have shown effectiveness in improving posture and reducing symptoms of upper crossed syndrome (UCS). Studies have highlighted the benefits of various exercises such as McKenzie and TheraBand exercises, selected corrective exercises, ischaemic compression (IC) of trigger points and muscle energy techniques (MET), comprehensive corrective exercises in water, and a selected corrective exercise program. These exercises have demonstrated significant improvements in pain, disability, muscle strength, forward head posture, rounded shoulder posture, kyphosis, scapula-humeral rhythm, and performance in individuals with UCS. The findings suggest that tailored exercise interventions play a crucial role in addressing postural abnormalities, reducing pain, and enhancing overall musculoskeletal health in individuals with upper crossed syndrome.
Are there simple exercises that can reduce shoulder pain for the general public?
4 answers
Yes, there are simple exercises that can help reduce shoulder pain for the general public. Research suggests that exercises can effectively reduce shoulder pain. Full-cycle rehabilitation exercises, including hospital and community-based interventions, have shown promise in managing shoulder pain in subjects with rotator cuff injury and adhesive capsulitis. Additionally, educational and exercise-based shoulder rehabilitation programs have been found to significantly improve pain, disability, and function in patients with rotator cuff-related shoulder pain. Furthermore, a comparison between corticosteroid injections and physiotherapist-led exercise therapy in primary care settings is ongoing to determine the clinical effectiveness and cost-effectiveness of these interventions for shoulder pain management. These findings collectively highlight the potential benefits of incorporating simple exercises into routine care for alleviating shoulder pain in the general population.
How does vitamine e work in complex ii in cancer treatment?
4 answers
Vitamin E analogues, such as α-tocopheryl succinate (α-TOS), exhibit potent anti-cancer properties by targeting the ubiquinone (UbQ) binding site(s) of mitochondrial complex II (CII). These analogues induce apoptosis in cancer cells by triggering excessive reactive oxygen species production and inhibiting succinate dehydrogenase activity of CII. Studies show that functional and reconstituted CII cells respond to α-TOS with reactive oxygen species generation and apoptosis, leading to tumor suppression in vivo, while dysfunctional CII cells do not respond. Furthermore, recent randomized control trials on Vitamin E's therapeutic role in cancer management suggest the need for well-designed trials to establish the safety and efficacy of Vitamin E supplementation in cancer treatment. Overall, Vitamin E analogues target CII in cancer cells, inducing apoptosis and suppressing tumor growth.
How does organizing home exercise practice affect the effectiveness of neuro rehabilitation for individuals with disabilities?
5 answers
Organizing home exercise practice significantly impacts the effectiveness of neurorehabilitation for individuals with disabilities. Home-based telerehabilitation (TR) programs have been shown to increase physical activity levels, improve muscular strength, body composition, and quality of life in persons with neurological disabilities, offering a safe, feasible, and effective alternative to traditional therapy. Additionally, home-based Virtual Reality (VR) exercise treatments have demonstrated improved functional ability, increased range of motion, and motivation, making them a cost-effective and safer option compared to in-hospital rehabilitation. Studies have also found that home rehabilitation programs are more effective in promoting long-term physical activity adherence in individuals with disabilities compared to standard in-office rehabilitation programs. Overall, home-based rehabilitation, including exercise programs and VR interventions, offers a practical and beneficial approach to enhancing neurorehabilitation outcomes for individuals with disabilities.
How effective is educational intervention in promoting cardiovascular health among adolescents?
4 answers
Educational interventions play a crucial role in promoting cardiovascular health among adolescents. Studies have shown that such interventions can significantly improve awareness of cardiovascular diseases (CVD), enhance health knowledge, behaviors, and objective measures like BMI and blood pressure, and reduce anxiety and depression in patients participating in cardiac rehabilitation programs. Implementing school-based multi-level interventions with community involvement has been effective in promoting physical activity and healthy behaviors among adolescents. Additionally, educational tools in primary care settings have proven to increase knowledge about CAD risk factors, emphasizing the importance of education in patient care management. Overall, educational interventions are instrumental in addressing cardiovascular health challenges in youth, highlighting the potential for long-term positive impacts on their well-being.