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When treatment with two or more AEDs fails, other treatment opportunities for drug-resistant epilepsy, including epilepsy surgery, vagal nerve stimulation, and dietary therapies should be considered.
In addition, it may have therapeutic effect for epilepsy.
This may be an effective treatment for refractory epilepsy.
Therefore, metabolic treatments appear to be promising alternative approaches for epilepsy.
The results provide a lead for potential benefit of adding CCBs to sodium valproate in the treatment of epilepsy, which needs to be explored further.

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