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Which Nsaid has the least anti inflammatory efficacy? 

Toxicity
Aspirin
Tolerability
Acetaminophen
Anti-inflammatory

Answers from top 10 papers

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Papers (10)Insight
Journal Article•DOI
Non-Steroidal Anti-Inflammatory Drugs
P. R. Blower
17 Jun 1993-Rheumatology
8 Citations
Pre-clinical studies suggest that, whilst NSAIDs have similar anti-inflammatory efficacy, the potential for producing side effects varies widely between members of this class of therapeutic agents.
Journal Article•DOI
Nonsteroidal Anti-inflammatory Drugs: Making the Right Choices.
Robert G. Berger
01 Sep 1994-Journal of The American Academy of Orthopaedic Surgeons
18 Citations
The superiority of one NSAID over another has not been clinically demonstrated in musculoskeletal conditions, nor has the efficacy of NSAIDs in noninflammatory rheumatic conditions been shown to be better than that of simple analgesics, such as acetaminophen.
Open access•Journal Article•DOI
An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis
Nuray Çakici, Nuray Çakici, N. J. M. van Beveren, G. Judge-Hundal, Maju Mathew Koola, Iris E. C. Sommer 
23 Aug 2019-Psychological Medicine
107 Citations
Some, but not all agents with anti-inflammatory properties showed efficacy.
Open access•Journal Article
Oral Analgesics for Acute Nonspecific Pain
Carolyn J. Sachs
01 Mar 2005-American Family Physician
94 Citations
In some cases, modest improvements in analgesic efficacy can be achieved by adding or changing to a nonsteroidal anti-inflammatory drug (NSAID).
Book Chapter•DOI
Towards safer nonsteroidal anti-inflammatory drugs.
Brune K, Beck Ws 
01 Jan 1991-Agents and actions
13 Citations
These observations indicate that certain pharmacokinetic characteristics of distinct nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible, at least in part, for well-known side-effects.
Journal Article•DOI
Tolerability and efficacy of nabumetone and naproxen in the treatment of rheumatoid arthritis
Hollis E. Krug, Larry K. Broadwell, Martin Berry, Ralph DeLapp, Robert H. Palmer, Maren L. Mahowald 
01 Jan 2000-Clinical Therapeutics
15 Citations
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) have similar efficacy at equipotent doses, but the therapeutic response to various NSAIDs often differs in individual patients.
Journal Article•DOI
Mechanism of action of anti-inflammatory drugs.
John R. Vane, Regina M. Botting 
01 Jan 1996-Scandinavian Journal of Rheumatology
410 Citations
A NSAID which selectively inhibits COX-2 is likely to retain maximal anti-inflammatory efficacy combined with less toxicity.
Open access•Journal Article•DOI
Association of Nonsteroidal Anti-Inflammatory Drugs with Lung Cancer: Results from a Large Cohort Study
Christopher G. Slatore, David H. Au, Alyson J. Littman, Jessie A. Satia, Emily White, Emily White 
01 Apr 2009-Cancer Epidemiology, Biomarkers & Prevention
63 Citations
The use of nonsteroidal anti-inflammatory drugs (NSAID) may be promising.
Journal Article•DOI
Efficacy and tolerability of preservative-free and preserved diclofenac and preserved ketorolac eyedrops after cataract surgery.
Saskia M. Maca, Michael Amon, Oliver Findl, Günal Kahraman, Talin Barisani-Asenbauer 
01 May 2010-American Journal of Ophthalmology
32 Citations
Anti-inflammatory efficacy was comparable for all 3 agents.
Journal Article•DOI
Severe necrotizing soft-tissue infections and nonsteroidal anti-inflammatory drugs
C. Souyri, Pascale Olivier, Sabrina Grolleau, Maryse Lapeyre-Mestre 
01 May 2008-Clinical and Experimental Dermatology
92 Citations
The use of nonsteroidal anti‐inflammatory drugs (NSAIDs) has been implicated as a contributing factor, but their role remains debated.

Related Questions

Is Etoricoxib vs other NSAIDS?5 answersEtoricoxib has been compared to other NSAIDs in terms of its efficacy and safety profile. In a meta-analysis, etoricoxib was found to have better analgesic activity compared to ibuprofen and diclofenac for postoperative pain after third molar surgery. It was also reported to significantly reduce the number of patients needing rescue analgesics compared to NSAIDs after third molar surgery. In the treatment of acute and chronic nonspecific back pain, etoricoxib has been shown to be superior to placebo and noninferior to diclofenac. In terms of safety, etoricoxib has a relatively low risk of gastrointestinal complications and its frequency of cardiovascular and renal complications is not higher than that of nonselective NSAIDs. However, etoricoxib has been associated with a greater propensity to destabilize blood pressure control compared to diclofenac and celecoxib.
Why anti inflammatory drugs?4 answersAnti-inflammatory drugs are used because they can help prevent and treat age-related diseases, reduce cancer risk, interfere with the tumor microenvironment, and minimize tissue damage in inflammatory diseases. These drugs, including non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids, have been widely used for their anti-inflammatory properties. NSAIDs, in particular, have been shown to reduce cell migration, increase apoptosis, and enhance chemo-sensitivity in cancer therapy. Additionally, plants have been studied for their potential as alternative anti-inflammatory agents with less toxicity. The development of new biological targets, such as NOD protein NLRP11, has also opened up possibilities for treating chronic inflammation diseases, autoimmune diseases, and tumors. Overall, anti-inflammatory drugs are important for managing inflammation and its associated complications in various diseases.
What is the effects of NSAIDs in bacterial infections?5 answersNSAIDs have been associated with the severity of bacterial infections, including skin and soft tissue infections (SSTI). Studies have reported septic complications such as dissemination of infection, suppuration, and the need for invasive procedures in patients with NSAID exposure. However, the rate of septic complications did not significantly differ between patients with severe sepsis or shock and those without. In children, NSAID exposure has been linked to severe bacterial infections such as cellulitis, abscesses, and pneumonia. Staphylococcus aureus, group A streptococci, and Streptococcus pneumoniae were commonly identified pathogens. The frequency of severe bacterial infections after NSAID exposure was elevated in children, but further research is needed to confirm these findings. NSAIDs may contribute to the progression of invasive group A streptococcal infections by inhibiting neutrophil function and augmenting cytokine production. However, the evidence regarding the effects of NSAIDs in bacterial infections is still limited and more studies are required.
How do NSAIDs affect diabetes mellitus?5 answersNSAIDs have various effects on diabetes mellitus (DM). Prolonged use of NSAIDs has been associated with a reduced risk of several cancer types and neurodegenerative diseases. However, the use of NSAIDs in DM patients should be carefully considered due to their potential impact on cardiovascular (CV) and gastrointestinal (GI) risks. A study found that inappropriate prescribing of NSAIDs was prevalent in DM patients at risk for significant GI and CV adverse events. Another study suggested that aspirin only marginally increases the bleeding risk in DM patients, possibly due to impaired platelet inhibition. Larger trials are needed to determine the relative cardioprotective benefits and bleeding risks of aspirin in these patients. Overall, the effects of NSAIDs on DM are complex and require careful consideration of individual patient risk profiles.
Are there any differences in the efficacy of NSAIDs and diacerein in the treatment of OA?5 answersThere is evidence to suggest that NSAIDs are effective in the treatment of osteoarthritis (OA). However, there is no specific mention of diacerein in the abstracts provided, so it is unclear whether there are any differences in efficacy between NSAIDs and diacerein for the treatment of OA.
Which is the best Nsaid for arthritis?2 answers

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