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In addition, the association between higher BMI and lean body mass with natriuretic peptides may be mediated by testosterone.
This study supports the idea that the testosterone-dependent aromatase system is directly innervated by a testosterone-dependent peptidergic system.
This increase is probably the result of peripheral conversion of androstenedione to testosterone.
Testosterone alone stimulates fat oxidation and protein synthesis, both of which are enhanced by GH.
We report here that treatment with testosterone increases the secretion of the nonamyloidogenic APP fragment, sbetaAPPalpha, and decreases the secretion of Abeta peptides from N2a cells and rat primary cerebrocortical neurons.
This effect is related to the androgenicity of the compounds of which testosterone is probably the most important.
Testosterone may increase androgen receptor (AR) immunoreactivity both by concentrating already existing ARs within the nucleus and by stimulating de novo synthesis of receptor protein.
These peptides are believed to act mainly by inhibiting the pituitary-testicular axis and, consequently, by reducing testosterone levels.
These parameters may improve with testosterone replacement therapy.
The time-course of the spectrum of effects of testosterone shows considerable variation, probably related to pharmacodynamics of the testosterone preparation.

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Does NMN help heart failure?
5 answers
Nicotinamide mononucleotide (NMN) is not directly addressed in the provided contexts. However, studies have focused on other compounds like inorganic nitrates or nitrites (INNs)and designer natriuretic peptides (NPs)for heart failure. NPs play a crucial role in cardiovascular homeostasis and HF management. Additionally, innovative designer NPs have shown promise in suppressing neurohormonal imbalances in HF. Furthermore, Dl-3-n-butylphthalide (NBP) has demonstrated protective effects on myocardial injury in HF mice by modulating the Nrf2/HO-1/Ca2+-SERCA2a axis. While NMN's specific effects on heart failure are not outlined, exploring its potential impact on pathways related to HF, such as oxidative stress and cardiac function modulation, could be a promising area for future research.
Are there any relationships between latentToxoplasma gondii infection, testosterone elevation, and risk of autism spectrum disorder?
5 answers
Latent Toxoplasma gondii infection has been associated with alterations in testosterone levels. Studies suggest that Toxoplasma-infected individuals, especially men, exhibit higher testosterone concentrations compared to non-infected individuals. Furthermore, Toxoplasma gondii infection has been linked to changes in behavior and personality, possibly through its impact on hormone levels. On the other hand, autism spectrum disorder (ASD) has been linked to factors like genetics, immune imbalance, and fetal testosterone levels. While the exact relationship between latent Toxoplasma gondii infection, testosterone elevation, and the risk of ASD remains unclear, the influence of Toxoplasma on testosterone levels and behavior, along with the role of testosterone in ASD etiology, suggests a potential avenue for further exploration into the interplay between these factors.
How does a high-fat diet affect the development of the circadian clock?
5 answers
A high-fat diet (HFD) significantly impacts the development and function of the circadian clock in various ways. Studies on mice show that HFD alters the rhythmicity of gene expression related to circadian rhythms and lipid metabolism. Specifically, HFD consumption disrupts the normal oscillations of circadian genes and metabolic pathways, leading to metabolic disturbances. In rats, short-term HFD consumption disrupts the circadian rhythms of the dorsomedial hypothalamus (DMH), a key brain structure controlling food intake and metabolism. Additionally, feeding mice an HFD affects the circadian transcriptome and metabolism of meibomian glands, highlighting the sensitivity of these glands to lipid composition in food. Overall, these findings emphasize the detrimental effects of a high-fat diet on the circadian clock, potentially leading to metabolic disorders and obesity.
Are steroids used in traumatic brain injury?
4 answers
Steroids are indeed utilized in traumatic brain injury (TBI) cases. Studies have shown that corticosteroid therapy can be beneficial in managing refractory intracranial hypertension (rICH) in severe TBI patients, potentially reducing the need for more invasive surgeries. Additionally, research indicates that steroid hormones like estrogens, androgens, and progesterone play a role in modulating TBI outcomes by regulating inflammation and oxidative stress, suggesting neuroprotective effects. Furthermore, the use of dexamethasone has been noted in the treatment of cerebral edema, a common complication in TBI patients, with different types of edema, such as cytotoxic and vasogenic, requiring specific management strategies. Therefore, steroids are indeed a part of the treatment arsenal for traumatic brain injuries, showing promise in various aspects of TBI management.
How does corticoid use affect water retention in the body?
5 answers
Corticoid use impacts water retention in the body through various mechanisms. Glucocorticoids like dexamethasone can initially increase urinary sodium excretion and reduce skin sodium and water content, compensating for renal sodium loss. Dexamethasone also promotes AQP2 protein expression, increasing water reabsorption in the kidneys, potentially leading to water retention. Additionally, glucocorticoids can suppress antidiuretic hormone (ADH) secretion, affecting water balance. Chronic glucocorticoid administration may activate the natriuretic peptide system in the hypothalamus, inhibiting dehydration-induced water intake and compromising renal water excretion, contributing to water retention. Overall, corticoid use can influence water retention by altering urinary sodium excretion, AQP2 activity, ADH secretion, and hypothalamic control of water intake.
What is the role of testosterone in the proliferation of cholangiocytes?
5 answers
Testosterone plays a crucial role in the proliferation of cholangiocytes. Cholangiocytes express androgen receptors (AR) and secrete sex hormones, including testosterone, which act as autocrine trophic factors stimulating biliary growth. In conditions of liver injury, such as cholestasis, testosterone levels decline, impacting cholangiocyte growth. Studies suggest that sex hormones, particularly testosterone, modulate cholangiocyte proliferation in liver injury, influencing the progression of liver diseases. Testosterone administration increases the expression of 17β-hydroxysteroid dehydrogenase 3 (17β-HSD3) in cholangiocytes, promoting their proliferation, which can be blocked by anti-testosterone agents or AR antagonists. Understanding the role of testosterone in cholangiocyte biology provides insights for potential therapeutic strategies in managing cholangiopathies.
How does low-carbohydrate diets affect men's health?
5 answers
Low-carbohydrate diets have shown various positive impacts on men's health. Research suggests that low-carbohydrate diets can potentially increase total serum testosterone levels and improve erectile function in hypogonadal men with metabolic syndrome. Additionally, low-carbohydrate diets may reverse many metabolic abnormalities induced by androgen deprivation therapy in prostate cancer patients, leading to weight loss, reduced fat mass, improved insulin resistance, and lipid profiles. However, long-term adherence to low-carbohydrate diets has been associated with reduced exercise performance in apparently healthy middle-aged men, along with a small unfavorable effect on their lipid profile. These findings highlight the potential benefits and considerations of low-carbohydrate diets in enhancing men's health outcomes.
What kind of nutrition can help male athlete to recover?
4 answers
Consumption of omega-3 fatty acids (n-3 FA) can aid in the recovery of male athletes. Omega-3 fatty acids have been shown to decrease delayed onset muscle soreness (DOMS) and fatigue, promoting better recovery and potentially enhancing athletic performance. Additionally, a combination of citrulline and nitrate-rich beetroot extract supplementation has demonstrated benefits in recovery by preventing an increase in cortisol levels and improving the distance covered in performance tests. Nutritional strategies such as tart cherries, beetroot, pomegranate, creatine monohydrate, and vitamin D supplementation can also help reduce exercise-induced muscle damage (EIMD). Furthermore, a high-carbohydrate diet is crucial for replenishing glycogen stores in muscles, aiding in the recovery process for athletes.
Has the topic of trans people in sport increased in the last years?
5 answers
The topic of trans people in sport has indeed gained significant attention in recent years. There has been a notable increase in the visibility of transgender individuals participating in athletic competitions, leading to efforts to include transgender women in women's categories while addressing concerns about potential advantages from exposure to male levels of testosterone. However, there is still a lack of inclusivity towards transgender athletes in various sports organizations, with many imposing prohibitions on their participation. Despite ongoing efforts towards greater inclusivity, there remains a significant gap in research regarding the social integration of transgender individuals in sports, particularly within intercollegiate athletics. The discourse surrounding trans athletes in women's sports has also sparked debates about the impact on cisgender women's experiences and rights, highlighting the need for allyship between cis and trans women in the realm of sports.
Assessment of welfare implications of transportation stress in poultry in southern Africa?
5 answers
Transportation stress in poultry, as highlighted in various studies, can significantly impact welfare and meat quality. Stressors during transportation include motion, vibration, feed withdrawal, and environmental factors, leading to physiological changes such as altered serum biochemical parameters, muscle metabolism, and meat quality. Studies emphasize the importance of maintaining physiological homeostasis during transportation to prevent negative impacts on bird welfare and production. The hypothalamic–pituitary–adrenal axis (HPA) plays a crucial role in responding to stressors, with corticosterone and cortisol secretion affected by transportation stress. Additionally, short-term transportation can induce transient alterations in hematochemical and immunological parameters, indicating the need for careful handling and transport practices to minimize stress and ensure poultry welfare in southern Africa.
How does smoking affect fibrenogen levels in men, and what potential health risks does this pose?
5 answers
Smoking has a significant impact on fibrinogen levels in men. Research shows that smokers have higher plasma fibrinogen levels compared to non-smokers, with a dose-dependent increase correlating with the number of cigarettes smoked daily. Increased fibrinogen synthesis in the liver is believed to play a primary role in this elevation, as evidenced by higher absolute fibrinogen synthesis rates in current smokers compared to non-smokers, which decrease upon smoking cessation. Elevated fibrinogen levels due to smoking are associated with cardiovascular risks, including coronary heart disease, stroke, and peripheral arterial disease, contributing to up to 50% of the increased CHD risk associated with smoking. This highlights the importance of understanding and addressing the impact of smoking on fibrinogen levels to mitigate cardiovascular health risks in men.