Which vitamin has the most powerful anti angiogenic properties?
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15 Citations | Furthermore, vitamin B12 reduces homocysteine levels in plasma, which is a significant anti-angiogenesis agent. |
15 Citations | Thus, vitamin C has anti-angiogenic properties. |
| As a result, we found that tocotrienol (T3), especially delta, beta, and gamma-T3 has the potent anti-angiogenic activity in vitro and in vivo experiments. | |
| Besides having antiproliferative properties, vitamin D might also reduce the invasiveness of cancer cells and act as an anti-angiogenesis agent. | |
| We conclude that vitamin E analogues selectively kill angiogenic endothelial cells, suppressing tumor growth, which has intriguing clinical implications. | |
15 Citations | Vitamin E, Tocopherols, exhibit anti-angiogenic effects by inhibition of proliferation and tube formation of endothelial cells through suppression of signaling pathways that are dependent on activation of PI3K/PDK/Akt signaling. |
13 Citations | These results suggest that vitamin K(3) amine derivatives with shorter alkyl chains, such as 1b, could be useful for developing anti-angiogenic agents. |
128 Citations | The results suggest that these two vitamin D3 analogues might be promising anti-angiogenic agents for controlling the angiogenesis which occurs in several pathological conditions, including tumor development. |
| s/Significance Taken together, our study demonstrated the distinctive anti-angiogenic properties of PA, both in vitro and in vivo. | |
57 Citations | These compounds show a potent anti-angiogenic activity at low dosages. |
Related Questions
How does retinol help in anti-angiogenesis?5 answersRetinol, also known as vitamin A, plays a role in anti-angiogenesis. It helps inhibit the formation of new blood vessels, a process known as angiogenesis, which is important in various diseases including diabetic retinopathy and age-related macular degeneration (AMD). In diabetic retinopathy, retinol can help prevent the development of abnormal blood vessels in the retina, which can lead to vision loss. In AMD, retinol can help inhibit the growth of abnormal blood vessels under the retina and macula, which can cause central vision loss. Additionally, retinol has been found to have anti-angiogenic effects in other diseases related to angiogenesis, such as hemangioma, psoriasis, rheumatoid arthritis, and menstrual disorders. Overall, retinol's ability to inhibit angiogenesis makes it a potential therapeutic option for various angiogenesis-related diseases.
How anti angiogenesis work?4 answersAnti-angiogenesis therapy is a method used in cancer treatment to inhibit the formation of new blood vessels, thereby reducing the nutrient and oxygen supply to the tumor. This therapy is often combined with other strategies such as chemotherapy and radiotherapy to enhance its effectiveness. Angiogenesis, the process of blood vessel formation, plays a crucial role in tumor growth and progression. By targeting angiogenesis, anti-angiogenic agents aim to normalize the microvascular network of tumors. These agents can decrease the density of capillaries in tumors of different sizes, leading to a reduction in microvascular density. The effectiveness of anti-angiogenic treatment may depend on the size and progression stage of the tumor. Overall, anti-angiogenesis therapy works by disrupting the angiogenic process and inhibiting the growth and spread of tumors.
Best vitamin for anticoagulation?3 answersVitamin K supplementation has been studied for anticoagulation control in patients taking warfarin. Two studies found that low-dose oral vitamin K (150-175 mcg) may improve INR control in patients with a high-variability response to warfarin. Another meta-analysis showed that oral and intravenous vitamin K are more effective than simply withholding warfarin for excessive anticoagulation. However, subcutaneous vitamin K was found to be inferior to oral and intravenous vitamin K and similar to placebo. A systematic review found limited evidence that vitamin K administration in patients with an INR between 4.5 and 10 without bleeding may not significantly benefit INR control and may have potential risks. Overall, the evidence suggests that low-dose oral vitamin K may be beneficial for anticoagulation control in patients with a high-variability response to warfarin, while intravenous and oral vitamin K are more effective for excessive anticoagulation. However, the use of vitamin K in patients with an INR between 4.5 and 10 without bleeding is uncertain and may carry risks.
What are the angiogenic motifs?5 answersAngiogenic motifs are important sequences within peptides that are required to exert anti-angiogenic activity. The sequence VHHQKLVFF has been identified as a potent anti-angiogenic motif. Additionally, the steric hindrance between alkyl chains and a rigid framework contributes to a high barrier to isomerization, which is important for angiogenesis modulation. Polypeptides with at least 80% sequence identity to specific sequences have also been found to be useful for modulating angiogenesis. Angiogenesis is a complex process influenced by multiple angiogenic factors that influence various events within a cascade of pathways. The mature vascular system is composed of a network of blood vessels, including arteries, capillaries, and veins, which are composed of endothelial cells surrounded by smooth muscle cells.
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