Search or ask a question

Who has leukemia in Imlie?

Monocytic leukemia

Friend leukemia

Answers from top 3 papers

PDF

Open Access

More filters

Papers (3)	Insight
Journal Article•DOI Surgical implications of pseudomonas aeruginosa necrotizing fasciitis in a child with acute lymphoblastic leukemia. Tang-Her Jaing, Chen-Sheng Huang, Cheng-Hsun Chiu, Yhu-Chering Huang, Man-Shan Kong, Wei-Mu Liu - Show less +5 more 01 Jun 2001-Journal of Pediatric Surgery 21 Citations	To our knowledge, this is the second case described in association with leukemia.
Journal Article•DOI Establishment, characterization and differentiation induction of a new human diploid myelomonocytic cell line (HL-92) derived from a patient with acute myelomonocytic leukemia. S. Zaki Salahuddin, Phillip D. Markham, Kenneth B. McCredie, Koji Kondo, Janet D. Rowley, Robert C. Gallo - Show less +5 more 01 Jan 1982-Leukemia Research 12 Citations	This is consistent with recent observations in monocytic leukemia.
Journal Article•DOI Establishment and characterization of a transplantable erythroblastic leukemia in C3H mice. Itoh K, Katsuhiko Ono, Hitoshi Sawada, Hitoshi Sawada, Tezuka H, Tezuka H, Hiroto Sakoda, Hiroto Sakoda, Hideo Nakane, Takashi Uchiyama, Haruto Uchino, Kazuhiro J. Mori - Show less +11 more 01 Jan 1988-Leukemia Research 14 Citations	This leukemia is distinguishable, in this respect, from diseases reported by Friend or Rauscher.

My columns

Related Questions

AML and CML?5 answersAML and CML are both types of leukemia. AML, or Acute Myeloid Leukemia, is a blood cell disorder that arises from gene mutations involved in hematopoiesis. It can develop de novo or progress from myeloproliferative disorders or myelodysplastic syndrome. CML, or Chronic Myeloid Leukemia, is characterized by uncontrolled proliferation of myeloid progenitors and is associated with the cytochrome P450 enzyme. LSCs, or leukemic stem cells, play a role in both AML and CML and can be refractory to standard therapies. The prevalence of CYP1A1*2C polymorphism in AML and CML patients was studied, but no significant differences were found in the genotypes. A CNN combined with transfer learning was used to classify and diagnose AML, ALL, and CML based on bone marrow cell microscopy images, resulting in improved accuracy compared to manual microscopy. Overall, understanding the characteristics and markers of LSCs in AML and CML is important for developing targeted therapies.

Can a blood culture show leukemia?13 answers

Does Stalin has leukemia?4 answers

Does leukemia cause acne?5 answers

How did Rishi Kapoor get leukemia?4 answers

Which cells are responsible for leukemia?2 answers

See what other people are reading

What's the IC50 of ceramide in Huh-7 cell line?

The IC50 of ceramide in the Huh-7 cell line is not explicitly mentioned in the provided contexts. However, data from various studies on ceramide's cytotoxic effects on different cancer cell lines can provide insights. Ceramide has shown cytotoxic activity on various cancer cell lines, including HEp-2, RD, AMGM5, REFAM3, and AMN3. Additionally, synthetic ceramide derivatives have demonstrated cytotoxicity in drug-resistant breast tumor cell lines, SKBr3 and MCF-7/Adr, with varying selectivity compared to normal breast epithelial cells. These studies highlight the potential cytotoxic effects of ceramide on cancer cells, but specific IC50 values for ceramide in the Huh-7 cell line would require further investigation beyond the provided contexts.What are the levels of lysozyme M in mouse serum?

The levels of lysozyme M in mouse serum can vary significantly depending on several factors, including health status, age, and exposure to pathogens or inflammatory conditions. Research has demonstrated that in mice with intra-abdominal abscesses, serum lysozyme levels were significantly increased compared to controls, indicating a high sensitivity and specificity of serum lysozyme levels in relation to the presence of an intra-abdominal abscess. Similarly, in mice subjected to lipopolysaccharide-induced inflammation, oral administration of lysozyme significantly suppressed inflammatory cytokine levels, suggesting that lysozyme can mitigate inflammatory conditions and potentially affect its own serum levels through feedback mechanisms. Age and disease conditions also influence lysozyme M levels. In older mice bearing spontaneous lymphocytic leukemia, higher concentrations of lysozyme were detected in kidney homogenates, although serum levels did not vary markedly between young and old mice or during the course of leukemic cell proliferation. Exposure to irradiation affects serum lysozyme levels in mice, with variations observed based on the dose of irradiation. In the context of infection, lysozyme M plays a crucial role in the defense against pathogens like Klebsiella pneumoniae, with genetically modified mice showing differences in bacterial killing efficiency and survival rates, which indirectly suggests variations in lysozyme M levels. Furthermore, infection with trypanosomes in various rodents, including mice, resulted in a rapid increase in lysozyme levels shortly after infection, indicating an immune response that elevates lysozyme levels in the serum. Assay methods, such as nephelometric and enzymatic assays, have been developed and refined for accurate measurement of serum lysozyme levels, demonstrating the importance of precise quantification in research and clinical settings. Structural studies of mouse lysozyme M have provided insights into its lower activity compared to other species, which could influence its concentration and activity in serum. Lastly, in leukaemic mice, an increase in serum lysozyme level was observed, correlating with a rise in neutrophils, further indicating the variability of lysozyme M levels in response to pathological conditions. In summary, lysozyme M levels in mouse serum are influenced by a complex interplay of factors including infection, inflammation, age, genetic modifications, and specific pathological conditions, with various studies highlighting the dynamic nature of lysozyme M in response to these factors.What is the effect of 'Cell adhesion molecules' in nasopharyngeal cancer?

Cell adhesion molecules play crucial roles in nasopharyngeal carcinoma (NPC). Studies have highlighted various effects of specific cell adhesion molecules in NPC progression. For instance, PECAM-1 induction by ionizing radiation contributes to cisplatin resistance in NPC cells. SSX2IP upregulation is associated with aggressive features and poor outcomes in NPC patients. EpCAM overexpression promotes metastasis through the PTEN/AKT/mTOR pathway in NPC cells. N-cadherin and β-catenin are elevated in NPC tissues, correlating with lymph node metastasis and advanced stages, impacting patient survival. These findings collectively emphasize the significant impact of cell adhesion molecules on NPC pathogenesis, progression, and patient outcomes.What are the current methods being used for replication of SARS-CoV-2 virus in laboratories?

Currently, laboratories are employing various methods for replicating SARS-CoV-2 virus. Reverse transcription-polymerase chain reaction (RT-PCR) is a highly useful technique for analyzing SARS-CoV-2 variants, especially during periods of high COVID-19 incidence. Additionally, circular polymerase extension cloning (CPEC) has been demonstrated as an efficient approach for generating full-length clones of SARS-CoV-2 and its variants, allowing for rapid and versatile engineering of mutations and insertions. Moreover, real-time cell analysis (RTCA) has been utilized to assess viral replication kinetics, providing a quantitative and rapid method to evaluate the replicative capacity of different SARS-CoV-2 variants, such as USA WA1/2020, Delta, and Omicron subvariants BA.1, BA.4, and BA.5. These methods collectively contribute to the comprehensive study of SARS-CoV-2 replication in laboratory settings.Is there any complement dependent cytotoxicity activity of cetuximab on A431 cells?

Cetuximab, when tested on A431 cells, did not exhibit complement-dependent cytotoxicity (CDC) activity. This was observed in a study where A431 cells were incubated with cetuximab, and subsequent staining did not show CDC activity. In contrast, another study focused on rituximab's CDC activity in lymphoma cells revealed a strong association between CDC susceptibility and response to rituximab-containing chemotherapy in diffuse large B-cell lymphoma and follicular lymphoma. The study highlighted the importance of CDC in rituximab's ability to induce remission, emphasizing its role as a predictor of therapeutic response. Therefore, while cetuximab did not demonstrate CDC activity on A431 cells, rituximab's CDC activity in lymphoma cells proved significant in predicting treatment outcomes.Which liver cells uptake mRNA covid vaccine?

Human liver cell line Huh7 has been shown to uptake the mRNA COVID-19 vaccine BNT162b2 rapidly, leading to changes in gene expression of LINE-1 and intracellular reverse transcription of the vaccine mRNA into DNA within 6 hours of exposure. Liver transplant recipients (LTRs) have also demonstrated immunological responses to mRNA-based COVID-19 vaccines, with most LTRs developing a positive anti-spike IgG response after receiving two doses of the Moderna vaccine. Additionally, chronic liver disease (CLD) patients exhibited good humoral responses to COVID-19 vaccines, with seroconversion rates ranging from 84% to 91% based on different antibodies, while LT recipients had a lower response rate, particularly after two doses of mRNA vaccines. Therefore, both in vitro and clinical studies suggest that liver cells, including Huh7 cells and liver transplant recipients, can uptake mRNA COVID-19 vaccines effectively.How mdr1 is tested?

MDR1 (P-glycoprotein) testing methods include in vitro assays using cell lines like MDR1-MDCKI and MDR1-MDCKII to predict brain penetration of drug candidates. Transgenic mouse models, such as MDR1-luc mice, have been developed to monitor human MDR1 transcription in the brain and spinal cord in vivo, providing a unique system to visualize MDR1 expression and regulation. Additionally, optimized gold nanoparticle beacons have been designed to detect MDR1 mRNA expression in living tumor cells, offering a promising strategy for real-time detection in individualized medication management. Experimental systems have been calibrated using MDR1 transport screening assays to predict drug interactions and brain penetration, with established thresholds and inhibitory potential assessments for better in vivo predictions. Veterinary practices can utilize cost-effective allele-specific methods for rapid genotype determination of MDR1 mutations in dogs, aiding in the prevention of neurotoxicity from certain drugs.Oligdendrocytes express glutamine synthetase ?

Oligodendrocytes do express glutamine synthetase (GS). Research indicates that GS is not only highly enriched in astrocytes but is also expressed in myelinating oligodendrocytes in the mouse and human ventral spinal cord. In normal conditions, GS expression in oligodendrocytes plays a role in metabolizing glutamate into glutamine, contributing to the regulation of glutamine levels in the spinal cord. Furthermore, studies have shown that GS expression in oligodendrocytes can be upregulated in chronic pathological conditions such as amyotrophic lateral sclerosis and multiple sclerosis, suggesting a potential role in disease progression. This evidence highlights the involvement of oligodendrocyte-expressed GS in normal spinal cord function and its dysregulation in neurological diseases.What are some specific examples of machine learning algorithms used in healthcare decision-making?

Machine learning algorithms play a crucial role in healthcare decision-making. Various algorithms are utilized in this field, such as support vector machines, artificial neural networks, decision trees, and naive Bayes. These algorithms are employed to handle the vast amount of medical data, enabling automatic identification of patterns and prediction of outcomes based on data. Additionally, modified ANOVA algorithms are used to identify marker leukemia genes, aiding in the examination of gene subsets that may increase the risk of developing leukemia. The integration of artificial intelligence into healthcare systems has led to the adoption of neural networks, support vector machines, and random forest/decision trees for clinical prediction, categorization, and disease prognosis primarily in oncology and neurology using imaging data.Why need to subculture the primary sulture in tissue culture technique?

Subculturing primary cell cultures in tissue culture techniques is essential for various reasons. Firstly, subculturing allows for the continuous growth and expansion of cells. It helps in maintaining the viability and health of the cells by providing fresh nutrients and removing waste products, preventing contact inhibition growth among cells. Additionally, subculturing aids in obtaining a homogeneous population of cells, as primary cultures are usually morphologically heterogeneous initially. By subculturing, researchers can isolate specific cell types and ensure consistent results in experiments. Moreover, subculturing is crucial for scaling up cell production for various applications, such as tissue engineering and regenerative medicine. Overall, subculturing primary cultures is vital for sustaining cell viability, purity, and functionality in long-term cell culture studies.What is the need for 3D Cell culture?

The need for 3D cell culture arises from its ability to closely mimic the natural in vivo environment, providing a more accurate representation of tissue microenvironments. This technology allows for the simulation of cell behaviors like attachment, migration, mitosis, and apoptosis, which differ from traditional 2D cultures. 3D cell culture models offer superior biocompatibility compared to 2D cultures, enabling the creation of organoids that better replicate in vivo structures and functions. By incorporating the third dimension, 3D cell cultures influence spatial organization, cellular responses, and molecular processes, leading to more realistic cellular phenotypes. These advancements have significantly impacted drug development, disease research, and precision medicine by providing platforms that better represent in vivo conditions, ultimately enhancing the evaluation and screening of active substances.