scispace - formally typeset
Search or ask a question

Who introduced Mycobacterium tuberculosis? 

Paleopathology
Ancient DNA
Mycobacterium tuberculosis
Mycobacterium
Tuberculosis

Answers from top 5 papers

More filters
Papers (5)Insight
Journal Article•DOI
Mycobacterium xenopei: A study of sixteen strains
A. Beck, J.L. Stanford 
01 Jun 1968-Tubercle
23 Citations
In our experience this organism was the second most frequent mycobacterium other than M. tuberculosis encountered in human clinical material.
Open access•Journal Article•DOI
Tuberculosis in the 21st century: an emerging pandemic?
Gunnar Bjune
01 Jan 2005
31 Citations
Molecular epidemiology done in Archangel, Russia, where most of the classical reasons for increase in tuberculosis were absent, indicated that strains of Mycobacterium tuberculosis with changed biological properties could be responsible.
Book Chapter•DOI
Host-pathogen interactions during Mycobacterium tuberculosis infections.
Sarah A. Stanley, Jeffery S. Cox 
01 Jan 2013-Current Topics in Microbiology and Immunology
93 Citations
The intimate and persistent connection between Mycobacterium tuberculosis and its human host suggests that the pathogen has evolved extensive mechanisms to evade eradication by the immune system.
Journal Article•DOI
Tuberculosis: from prehistory to Robert Koch, as revealed by ancient DNA.
Helen D. Donoghue, Mark Spigelman, Mark Spigelman, Charles L. Greenblatt, Galit Lev-Maor, Gila Kahila Bar-Gal, Carney Matheson, K Vernon, Andreas G. Nerlich, Albert Zink 
01 Sep 2004-Lancet Infectious Diseases
184 Citations
This has provided direct support for the current theory of Mycobacterium tuberculosis evolution, and suggests areas of investigation for the interaction of M tuberculosis with its host.
Journal Article•DOI
Identification of Mycobacterium DNA in an Egyptian Pott's disease of 5400 years old
Eric Crubézy, Bertrand Ludes, Jean-Dominique Poveda, John Clayton, Brigitte Crouau-Roy, Daniel Montagnon 
01 Nov 1998-Comptes Rendus De L Academie Des Sciences Serie Iii-sciences De La Vie-life Sciences
106 Citations
We cannot prove that it is M. tuberculosis, M. bovis or an ancient mycobacteria resembling the two current forms because the observed modifications in the sequence could be attributed to the antiquity of Mycobacterium and/or to the effects of Taq polymerase.

Related Questions

What is the history of tuberculosis?5 answersTuberculosis (TB) has a long history, dating back more than 40,000 years. The disease was described in ancient India, China, and the Bible. In the Middle Ages, a new clinical form of TB called scrofula was identified, and it was believed that those affected could be healed by a royal touch. TB was epidemic in Europe and America in the 18th and 19th centuries, particularly affecting young people and the poorer classes. Paleopathological evidence shows that TB has been present since ancient times, with evidence dating back to 8000 BCE. The discovery of the tubercle bacillus by Robert Koch in 1882 led to significant advancements in research and the development of vaccines and antimicrobial treatments. Despite these advancements, TB continues to be a challenge today, with the emergence of drug-resistant strains.
How can you grow Mycobacterium tuberculosis in laboratory?4 answers
Is Mycobacterium tuberculosis Cocci?3 answers
What is the scientific name for Mycobacterium tuberculosis?4 answers
Which milk is good for tuberculosis?7 answers
Which scientist discovered Mycobacterium tuberculosis?5 answers

See what other people are reading

What are the current research trends in the prevention of tuberculosis (TB) in India?
5 answers
Who is person deprived of liberty?
4 answers
What are the impact of rural-urban migration on municipality of South Africa?
5 answers
What are the impact of rural-urban migration on municipality of South Africa?
5 answers
Why does acquired tuberculosis drug resistance?
5 answers
What are the potential implications of the findings in the study published at <https://doi.org/10.1186/s43093-024-00308-6>?
4 answers
Why synergestic plant therapy is utilized to ameliorate toxicity?
5 answers
Synergistic plant therapy is employed to ameliorate toxicity due to the potent effects of combining multiple plant extracts, enhancing their individual benefits. Studies show that plant combinations like Geranium wallichianum, Elaeagnus parvifolia, and Taraxacum officinale have hepatoprotective effects against liver damage induced by toxins. Phytoremediation, utilizing plants and associated microbes, efficiently removes pollutants without generating secondary pollutants, showcasing the synergistic relationship between plants and microbes. Additionally, plant compounds in combination with conventional drugs, such as ginger, reduce drug toxicity and combat resistance in tuberculosis treatment. Clinical trials on herb-drug interactions emphasize the importance of proper evidence-based integrative therapies to mitigate toxicity and enhance treatment efficacy. Furthermore, the synergistic benefits of combining Purslane and Chicory extracts show promising results in ameliorating testicular dysfunction induced by glucocorticoids.What is tubercolosis?
5 answers
Tuberculosis (TB) is a highly infectious disease caused by Mycobacterium tuberculosis, affecting various organs, primarily the lungs. It is a significant global health concern, with around one-third of the world's population estimated to be infected. TB diagnosis involves expert interviews and laboratory testing of sputum samples, which can be time-consuming. The disease spreads easily through the air when infected individuals cough or sneeze, leading to potential severe consequences if left untreated. Despite the availability of the BCG vaccine for prevention, its limitations in protecting only children and preventing severe forms of TB highlight the need for more effective vaccines. Developing advanced anti-TB drugs with potent and rapid action mechanisms is crucial to combat drug-resistant strains and enhance treatment outcomes.What are the computational tools and techniques used for the analysis of plant metabolites antibacterial activity through sequential docking?
4 answers
Computational tools and techniques utilized for analyzing plant metabolites' antibacterial activity through sequential docking include deep neural network models (DNN), molecular docking, and ADMET analysis. DNN models were developed to predict antibacterial properties of metabolites based on fingerprints, correlation-based similarities, and structurally similar compound clusters. Molecular docking studies were conducted to screen phytocompounds against specific bacterial enzymes, such as aminoacyl-tRNA synthetase (AaRS) and enoyl-(acyl carrier protein)-reductase (InhA). Additionally, ADMET analysis was performed to assess drug-likeness properties of the phytocompounds. These computational approaches aid in identifying potential antibacterial agents from plant metabolites for drug development against bacterial infections.What are the effects of earthquake ( as per 50 citations)?
5 answers
Earthquakes have multifaceted effects on various aspects of human life. They can lead to immediate medical needs at the epicenter and secondary health problems in other areas. Post-earthquake, infectious diseases can surge due to factors like lack of clean water, food, and hygiene, along with disruptions in essential services like water and electricity supply. Furthermore, earthquakes are associated with the development of posttraumatic stress disorder (PTSD) and depression, emphasizing the importance of preventive measures and effective coping strategies. Demographically, earthquakes can impact reproductive outcomes, as seen in the significant rise in childbirth rates and reduced birth spacing following the 2001 Gujarat earthquake, with variations based on location, socioeconomic status, and parental characteristics.Docking Study with IC50 VALUE
5 answers
The docking study conducted in various research papers aimed to analyze the binding interactions of different compounds with specific target proteins, correlating these interactions with their IC50 values. For instance, in the study by Xia et al., compound 4 exhibited strong antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 2 μg/mL, and its docking to the KatG enzyme was highlighted as a key factor in its efficacy. Similarly, Taha et al. synthesized bisindole analogs and evaluated their anti-leishmanial potential, showing outstanding inhibitory activity with IC50 values ranging from 0.7 ± 0.01 to 13.30 ± 0.50 µM, with molecular docking aiding in understanding the binding interactions of these active molecules. These studies demonstrate the importance of molecular docking in elucidating the mechanisms underlying the IC50 values of bioactive compounds.