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Why did they make metastasis show? 

Karyotype
Epithelial–mesenchymal transition
Cardiothoracic surgery
Metastasis
Malignancy

Answers from top 8 papers

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Papers (8)Insight
Open access•Journal Article•DOI
Tumour progression and metastasis
Francisco Arvelo, Felipe Sojo, Carlos Cotte 
29 Jan 2016-Ecancermedicalscience
63 Citations
It also suggests that the metastatic niche can be an ideal target for new treatments that make controlling metastasis possible.
Open access•Journal Article
Does surgery promote the development of metastasis in melanoma
Pinsolle, Alain Ravaud, Baudet J 
01 Aug 2000-Annales De Chirurgie Plastique Esthetique
10 Citations
Surgery itself as well as the surgical stress could also make easier metastasis spread owing to antitumor immune mechanisms disturbance.
Open access•Journal Article
Determination of clonality of metastasis by cell-specific color-coded fluorescent-protein imaging.
Norio Yamamoto, Meng Yang, Ping Jiang, Mingxu Xu, Hiroyuki Tsuchiya, Katsuro Tomita, A. R. Moossa, Robert M. Hoffman 
15 Nov 2003-Cancer Research
85 Citations
We conclude that spontaneous metastasis may be clonal because they are rare events, thereby supporting the rare-cell clonal origin of metastasis hypothesis.
Open access•Journal Article•DOI
Understanding the molecular mechanisms driving metastasis.
Joan Massagué, Eduard Batlle, Roger R. Gomis 
01 Jan 2017-Molecular Oncology
58 Citations
Metastatic dormancy may explain why metastasis occurs years or even decades after primary tumor resection.
Journal Article•DOI
The P2X7 Receptor in the Maintenance of Cancer Stem Cells, Chemoresistance and Metastasis
Vanessa Fernandes Arnaud-Sampaio, Izadora Lorrany Alves Rabelo, Henning Ulrich, Claudiana Lameu 
01 Apr 2020-Stem Cell Reviews and Reports
25 Citations
Indeed, they have a unique phenotypic plasticity, allowing the acquisition of features that make them successful in all steps of metastasis.
Journal Article•DOI
Key Questions in Metastasis: New Insights in Molecular Pathways and Therapeutic Implications
Geraldine Gueron, A De Siervi, Elba Vazquez 
31 Oct 2011-Current Pharmaceutical Biotechnology
14 Citations
These metastasis-prone genes support primary tumor growth through one particular effect, whereas they enhance distant metastasis through another effect.
Journal Article•DOI
Pulmonary metastasis from colorectal carcinoma with hepatic metastasis
Takuma Tsukioka, Noritoshi Nishiyama, Takashi Iwata, Koshi Nagano, Nobuhiro Izumi, Shinjiro Mizuguchi, Ryuhei Morita, Kiyotoshi Inoue, Shigefumi Suehiro 
12 Nov 2007-The Japanese Journal of Thoracic and Cardiovascular Surgery
12 Citations
Patients with synchronous metastases had a poorer prognosis than did the patients in the other two groups. Surgical treatments for patients with pulmonary metastasis alone or metachronous metastasis can provide a beneficial outcome.
Journal Article•DOI
Skeletal metastases in 102 patients evaluated before surgery for renal cell carcinoma.
Christen Henriksson, G. Haraldsson, Frank Aldenborg, S. Lindberg, S. Pettersson 
01 Jan 1992-Scandinavian Journal of Urology and Nephrology
49 Citations
Solitary bone metastasis must be diagnosed early since they may be radically removed.

Related Questions

What are the names of each step of metastasis?4 answersMetastasis, the complex process of cancer spread, involves several distinct steps. These steps include local invasion of tumor cells, intravasation into the vasculature, survival in circulation as circulating tumor cells (CTCs), extravasation into secondary organs, and colonization leading to metastatic outgrowth. The process also encompasses interactions with stromal cells, adaptation to new environments, evasion of immune responses, and establishment of a metastatic niche. Different types of cell movements, such as collective, mesenchymal, and amoeboid migration, play crucial roles in metastasis. Additionally, factors like epithelial-mesenchymal transition (EMT), genetic changes facilitating migration, and establishment of a vascular network within secondary sites are essential components of the metastatic cascade. Understanding and targeting these steps are crucial for developing effective anti-metastatic strategies.
How do cancer stem cells affect metastasis?5 answersCancer stem cells (CSCs) play a crucial role in metastasis by driving tumor growth, therapy resistance, and the spread of cancer. CSCs possess unique abilities like self-renewal, slow proliferation, and the capacity for epithelial-mesenchymal transition (EMT), which enables them to detach, migrate, invade, and complete the metastatic cascade. Studies suggest that CSCs are responsible for the initiation of metastatic events, emphasizing their significance in the metastatic process. Furthermore, the presence of CSC-derived extracellular vesicles (EVs) has been linked to tumor progression, metastasis, and chemoresistance, highlighting the impact of CSCs on cancer spread and treatment failure. Understanding and targeting CSCs may offer promising strategies to impede metastasis and enhance cancer treatment outcomes in the future.
Why are we studying cancer metastasis?3 answersCancer metastasis is being studied because it is the leading cause of mortality in cancer patients. Understanding the mechanisms underlying cancer metastasis is crucial for developing effective diagnostic and therapeutic strategies against this disease. Metastasis involves a complex and multi-step process, and studying it can help in identifying the factors that contribute to cancer spreading to other organs. Additionally, studying cancer metastasis can provide insights into how cancer cells adapt to different tissue environments and overcome challenges such as physical confinement. It is also important to study metastasis because current cancer treatments may have the potential to induce metastasis, highlighting the need to minimize the risk of metastasis during treatment. By studying cancer metastasis, researchers can develop better models and assays to replicate the tumor microenvironment and investigate the behavior of cancer cells in different tissues.
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