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Why do zinc pills give me a headache? 

Medicine
Zinc
Rostral ventromedial medulla
Migraine
Headaches

Answers from top 13 papers

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Papers (13)Insight
Open access•Journal Article•DOI
Exploring the effects of extracranial injections of botulinum toxin type A on prolonged intracranial meningeal nociceptors responses to cortical spreading depression in female rats
Agustin Melo-Carrillo, Agustin Melo-Carrillo, Andrew M. Strassman, Andrew M. Strassman, Aaron J. Schain, Aaron J. Schain, Rodrigo Noseda, Rodrigo Noseda, Sait Ashina, Sait Ashina, Aubrey Manack Adams, Mitchell F. Brin, Rami Burstein, Rami Burstein 
31 Aug 2019-Cephalalgia
20 Citations
in the cortex), a peripherally acting drug can intercept/prevent the headache.
Open access•Journal Article•DOI
Zinc deficiency induces behavioral alterations in the tail suspension test in mice. Effect of antidepressants.
Katarzyna Młyniec, Gabriel Nowak, Gabriel Nowak 
01 Mar 2012-Pharmacological Reports
69 Citations
These results indicate the developing response to zinc deficiency induced by a zinc-deficient diet.
Journal Article•DOI
Pizotifen(BC-105): A Review of its Pharmacological Properties and its Therapeutic Efficacy in Vascular Headaches
T. M. Speight, G. S. Avery 
01 Jan 1972-Drugs
97 Citations
In other forms of headache, such as tension or muscle contraction headache, post-traumatic headache, inflammatory headache and trigeminal neuralgia, pizotifen has generally had little effect.
Open access•Journal Article•DOI
Sustained morphine-induced sensitization and loss of diffuse noxious inhibitory controls in dura-sensitive medullary dorsal horn neurons.
Akiko Okada-Ogawa, Frank Porreca, Ian D. Meng 
16 Dec 2009-The Journal of Neuroscience
86 Citations
These results are consistent with studies demonstrating a loss of DNICs in patients that suffer from chronic daily headache and may partially explain why overuse of medication used to treat migraine can induce headaches.
Journal Article•DOI
The cytokine theory of headache.
R.S. Smith
01 Oct 1992-Medical Hypotheses
34 Citations
This unifying concept can not only account for headache, but also the prostaglandins, leukotrienes, platelet activating and vasoactive substances linked with headache, the varied symptoms associated with headache and the high incidence of headache with depression, infectious disease, trauma and in premenopausal women.
Journal Article•DOI
The importance of headaches in neurology clinics. Study groups of neurologists of Aragon
Gracia-Naya M
01 Sep 1999-Revista De Neurologia
Headache is the commonest cause for consulting a neurologist.
Journal Article•DOI
Headache as a presenting feature in patients with serotonin syndrome: A case series:
Sanjay Prakash, Pooja Belani, Aditi Trivedi 
01 Feb 2014-Cephalalgia
A review of the literature suggests that some overlaps exist in the pathophysiology between SS and headache disorders, including medication-overuse headache.
Journal Article•DOI
Temporomandibular Pain Dysfunction: Can Electrotherapy Help?
R. J. M. Gray, A. A. Quayle, C. A. Hall, M. A. Schofield 
01 Jan 1995-Physiotherapy
20 Citations
Headache may also be a symptom.
Journal Article•DOI
Headache induced by a nitric oxide donor (nitroglycerin) responds to sumatriptan. A human model for development of migraine drugs.
Helle K. Iversen, Jes Olesen 
01 Oct 1996-Cephalalgia
148 Citations
The results suggest that NTG headache in non-migraineurs may share mechanisms with migraine headache.
Journal Article•DOI
Toward a pragmatic migraine model for drug testing: 1. Cilostazol in healthy volunteers:
Emma Katrine Hansen, Song Guo, Messoud Ashina, Jes Olesen 
01 Feb 2016-Cephalalgia
14 Citations
Conclusion Despite similarities with migraine headache, cilostazol-induced headache in healthy volunteers does not respond to sumatriptan.
Open access•Journal Article•DOI
Effects of zinc supplementation on 1- to 5-year old children
Adriana P. R. Silva, Adriana P. R. Silva, Adriana P. R. Silva, Márcia Regina Vitolo, Luis Fabrício Zara, Carlos Frederico de Souza Castro 
01 May 2006-Jornal De Pediatria
45 Citations
Zinc supplementation improved hemoglobin response and normalized serum zinc concentration.
Journal Article•DOI
Basic Science: Mechanisms of Medication Overuse Headache
Ian D. Meng, Frank Porreca 
01 Nov 2004-Headache Currents
In the headache sufferer, these adaptations could lead to medication overuse headache.
Journal Article•DOI
Zinc and Excitotoxic Brain Injury: A New Model:
Christopher J. Frederickson, Wolfgang Maret, Math P. Cuajungco 
01 Feb 2004-The Neuroscientist
122 Citations
The authors present a new model of zinc currents and zinc toxicity that offers expanded opportunities for zinc-selective therapeutic chelation interventions.

Related Questions

Can zinc excess led to nausea and vomiting?5 answersExcessive zinc intake can lead to nausea and vomiting. Zinc toxicity can occur through overdosage of zinc supplements, which is increasing due to lack of awareness. In a study conducted on under-five children with acute diarrhea, it was found that the unpleasant taste of zinc tablets often caused nausea and vomiting. Another study observed adverse events in children after the administration of zinc, and vomiting or regurgitation was reported as a transient side effect. These studies suggest that zinc excess can indeed lead to nausea and vomiting, but the symptoms are usually transient and do not impact the continuation of zinc treatment.
Does birth control have zinc in it?4 answers
Does taking zinc make you urinate more?12 answers
What happens if you take zinc with other vitamins?5 answers
What should I eat if I take too much zinc?4 answers
Why does taking zinc give me a headache?6 answers

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