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Why does cirrhosis cause high AST?

Chronic liver disease

Primary biliary cirrhosis

Cell activation

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Journal Article•DOI Incidence of cholelithiasis among patients with cirrhosis and portal hypertension. H V Steinberg, William W. Beckett, Judith L. Chezmar, William E. Torres, Frederick B. Murphy, Michael E. Bernardino - Show less +5 more 01 Oct 1988-Abdominal Imaging 19 Citations	We believe the severity and duration of cirrhosis in our patient population, all with documented portal hypertension, may be the cause of this increased incidence.
Journal Article•DOI Ratio of Serum Aspartate to Alanine Aminotransferase in Chronic Hepatitis Relationship to Cirrhosis Ann Williams, Jay H. Hoofnagle - Show less +1 more 01 Sep 1988-Gastroenterology 467 Citations	Thus, the finding of an AST/ALT ratio of greater than 1.0 in a patient with nonalcoholic liver disease should suggest the presence of cirrhosis.
Journal Article•DOI An assessment of the clinical utility of serum ALT and AST in chronic hepatitis C. Frank H Anderson, Lecheng Zeng, Natalie R Rock, Eric M. Yoshida - Show less +3 more 01 Jul 2000-Hepatology Research 83 Citations	An AST/ALT ratio >/=1 is highly suggestive of the presence of cirrhosis.
Journal Article•DOI Markers of cell activation and apoptosis in bone marrow mononuclear cells of patients with autoimmune hepatitis type 1 and primary biliary cirrhosis. Aikaterini Tsikrikoni, D. Kyriakou, Eirini I. Rigopoulou, Michael G. Alexandrakis, Kalliopi Zachou, Freda Passam, Georgios N. Dalekos - Show less +6 more 01 Mar 2005-Journal of Hepatology 37 Citations	Cirrhosis appears unlikely to be the cause of the above findings.
Journal Article•DOI Increased ascitic level of hyaluronan in liver cirrhosis Kar Neng Lai, Cheuk-Chun Szeto, Christopher W.K. Lam, Ka Bik Lai, Teresa Y.H. Wong, Joseph Leung - Show less +5 more 01 Apr 1998-Journal of Laboratory and Clinical Medicine 13 Citations	We conclude that a high level of HA is found in ascites from patients with cirrhosis.
Open access•Journal Article•DOI Prognosis of Patients with Cirrhosis and AKI Who Initiate RRT Andrew S. Allegretti, Xavier Vela Parada, Nwamaka D. Eneanya, Hannah Gilligan, Dihua Xu, Sophia Zhao, Jules L. Dienstag, Raymond T. Chung, Ravi Thadhani - Show less +8 more 06 Jan 2018-Clinical Journal of The American Society of Nephrology 84 Citations	Cause of AKI was not significantly associated with mortality in patients with cirrhosis who required RRT.

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