Search or ask a question

Why inflammation happens?

Vascular permeability

Innate immune system

Medical diagnosis

Best insight from top research papers

Inflammation occurs as a normal physiological response to injury, infection, or other challenges to homeostasis . It is a protective mechanism that aims to eliminate the cause of damage, remove damaged cells, and initiate tissue healing and repair . Acute inflammation is a short-term, self-limiting response that helps control infections and promote wound healing . However, chronic inflammation can occur when the mission of acute inflammation is not accomplished, leading to ongoing oxidative stress and disease onset . Chronic inflammation can be caused by various factors such as persistent infection, chronic non-infectious diseases, aging, and chronic trauma . While inflammation is intended to benefit the body, an inflammatory response can go awry, resulting in collateral damage to healthy tissues and exacerbation of disease . Therefore, understanding the causes and mechanisms of inflammation is crucial for effective medical treatment and management .

Answers from top 5 papers

PDF

Open Access

More filters

Papers (5)	Insight
Journal Article•DOI An inflammation classification system using cytokine parameters. Kevin Roe 01 Feb 2021-Scandinavian Journal of Immunology 33 Citations	Inflammation can be caused by various factors such as blood clots, immune system disorders, infections, cancers, chemical exposures, physical injuries, or neurological conditions.
Book Chapter•DOI Inflammation 01 Jan 2022	Inflammation happens as a protective response to injury or infection, helping to eliminate the cause of injury and initiate tissue healing and repair.
Book Chapter•DOI An Overview of Inflammation M.B. Furie 01 Jan 2014 4 Citations	Inflammation happens as a reaction to tissue injury and is designed to eliminate the cause of damage and promote healing.
Book Chapter•DOI Inflammation: A multifaceted and omnipresent phenomenon 01 Jan 2023 1 Citations	Inflammation happens as a normal physiological process to maintain homeostasis, repel foreign invaders, and initiate healing response, triggered by various environmental factors.
Book Chapter•DOI Inflammation Salaheldin Mohamed Ahmed 01 Jan 2023	Inflammation happens as a protective response to invasion, injury, and other challenges to homeostasis, but chronic inflammation occurs when the mission is not accomplished.

My columns

Related Questions

What are the effects of inflammation on the brain?4 answersInflammation in the brain can have various effects. It can lead to redness, swelling, heat, pain, and loss of function, similar to the effects of inflammation in other parts of the body. In neuropsychiatric disorders, neuroinflammation can cause neuronal or glial atrophy or death, disruptions in neurotransmitter signaling, and cognitive and behavioral changes. Neuroimaging studies have shown potential disruptions in the choroid plexus and blood-brain barrier, which can affect the transfer of ions, molecules, toxins, and cells from the periphery into the brain. Systemic inflammation can also impact cerebral blood vessels, leading to impaired oxygen availability and disturbances in neurovascular coupling. These vascular changes and impaired oxygen availability may contribute to the long-term risk of neurodegenerative changes associated with chronic, systemic inflammation.

How does pain affect inflammation?3 answersPain affects inflammation in multiple ways. Inflammatory mediators can activate peripheral nociceptors, leading to pain. Changes in the responsiveness of nociceptive nerve endings can cause ongoing pain and lowered pain thresholds, resulting in hyperalgesia. Inflammation can stimulate angiogenesis, which can facilitate pain. Inflammatory processes in the peripheral and central nervous systems contribute to the development and maintenance of chronic pain. On the other hand, leukocytes release opioid peptides in inflamed tissue, counteracting the effects of inflammation and reducing pain. Macrophages and glial cells in the peripheral and central nervous systems can also promote pain resolution through the release of anti-inflammatory mediators and specialized pro-resolving mediators. Overall, pain and inflammation have a complex relationship, with inflammation contributing to pain sensitization and chronic pain, while pain can also influence the inflammatory process.

What specific bacteria that causes inflammation?3 answersSpecific bacteria that can cause inflammation include Helicobacter hepaticus, Proteobacteria, Pseudomonas aeruginosa, and certain subtypes of Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans, and Campylobacter rectus. These bacteria have been shown to induce chronic intestinal inflammation, inflammatory bowel disease, pulmonary inflammation, and extra-oral infections and inflammation. The degree of inflammation can be influenced by the specific composition of bacterial strains and their interactions with other bacteria. Additionally, the inflammatory response may be regulated by factors such as gut microbiota composition, immune response, and host genetic factors. Further research is needed to fully understand the mechanisms by which these bacteria induce inflammation and their role in various diseases.

What are different signs of inflammation?9 answers

What are the different signs of inflammation?9 answers

Which are the signs of inflammation?10 answers

See what other people are reading

How can these approaches be used to understand social phenomena?

Agent-based modelling (ABM) is an effective methodology for studying the mechanisms underlying the dynamic characteristics of social phenomena. ABM allows for the understanding of complex social phenomena by capturing the interactions between individuals, their environment, and the feedback between them. ABM simulations involve social agents interacting in autonomous, adaptive, and interdependent ways, providing a method to theorize and test mechanisms behind complex social phenomena, even in the absence of empirical data. Social simulation, using advanced computational capabilities, offers a new paradigm for understanding social complexity and constructing virtual laboratories to test and validate hypotheses of social phenomena. By utilizing omics approaches, such as examining gene expression and genome evolution, sociality in natural populations can be clarified, and the consequences of sociality can be explored. These approaches provide valuable tools for understanding social phenomena by capturing the interactions, behaviors, and feedback between individuals and their environment.How does the immune response inhibit mycotoxins?

The immune response inhibits mycotoxins by modulating the host's immune system and enhancing immune defenses. Fungal toxins, including mycotoxins, can have a deleterious impact on health and can disrupt immune homeostasis. Research suggests that mycotoxins can modulate immune responses, but our understanding of the mechanisms involved is incomplete. In one study, it was found that mycotoxins such as Zearalenone (ZEA) and deoxynivalenol (DON) can negatively regulate the levels of Nitric oxide (NO) through the toll-like receptors 2 (TLR2)/nuclear factor kappa-B (NFκB) pathway, inhibiting the innate immune responses of the liver. Another study showed that mycotoxins can trigger the production of CXCL17, a chemokine involved in immune response, which in turn modulates enhanced immuno-protective responses and ameliorates mycotoxin-induced inflammation and apoptosis. These findings suggest that the immune response plays a crucial role in inhibiting mycotoxins and protecting against their harmful effects.How does divorce affect of children?

Divorce has a negative impact on children in various ways. It affects their educational achievements, leading to academically weak children and a decline in their academic level. Divorce also affects children's growth and development, as they receive less than optimal care from their parents. Furthermore, the consequences of marital dissolution may adversely affect children's success in their future romantic relationships. High-conflict parental relationships, which are often present during and after divorce, can make it difficult for children to form their own healthy relationships. Divorce also affects the personality, learning interests, and mental development of teenagers, as they still need the love and attention of both parents. The effects of divorce on children are emotional, psychological, economical, and religious, among others. Overall, divorce has a significant impact on children's well-being and future prospects.Is silk good for hair and skin?

Silk is beneficial for hair and skin. It can provide a smooth and durable film to protect against damage from the environment, chemicals, and grooming. Silk proteins, whether natural or synthetic, can be used in cosmetic or dermatological compositions. High molecular weight proteins found in silk, when processed into scaffolds, have been shown to enhance wound healing in human skin. Silk-derived compositions, such as silk solutions and silk mats, can be applied to the skin surface to prevent wounds and promote wound healing. Silk peptides with a specific molecular weight distribution can be used in skin cosmetics to inhibit the formation of melanin pigment and provide moisturizing effects.What are the challenges and opportunities for diversity in talent management research?

Diversity in talent management research presents both challenges and opportunities. The growing diversity of organizations' workforce necessitates a reassessment of conventional HRM approaches. The development of a global talent market creates a complex and substantial talent pool, but also brings geographic and cultural differences that need to be addressed. The debate between inclusive and exclusive talent management approaches highlights the tensions in managing diverse talents. Different generations have different values and perceptions, requiring companies to adapt and develop talent management practices for each generation. Research methods play a crucial role in studying organizational diversity, and this book aims to provide insights into potential research designs for diversity studies in contemporary organizations. By addressing these challenges and leveraging the opportunities, organizations can enhance their talent management practices and achieve higher levels of employee satisfaction and long-term results.How does Dahl's concept of power relate to other theories of power?

Dahl's concept of power is related to other theories of power in several ways. Firstly, Pettit argues that Dahl's analysis of power needs some corrections and extensions, but when corrected and extended, it provides a base for articulating radical points of view and defining control or domination that opposes freedom. Secondly, Lamarche examines the use of nonviolence by the Ottawa Panhandlers' Union using Dahl's theory of power as capacity, which focuses on the ability to force others to take specific actions. Lastly, Haugaard theorizes the four dimensions of power, which builds upon the work of Dahl, Lukes, Foucault, Bourdieu, and Giddens, among others. These connections show that Dahl's concept of power is influential and has been built upon and expanded by other theorists in the field.How does divorce effect children?

Divorce has a negative impact on children in various aspects. It affects their educational achievements, leading to a decline in academic performance and weakens their social integration and engagement in society. The pattern of parenting after divorce plays a crucial role in children's growth and development, and if not done properly, it can have detrimental effects on the child's well-being. Children who experience their parents' divorce face multiple stressors that increase the risk of developing adjustment problems, anxiety, depression, behavioral issues, and poor academic achievement. The effects of divorce on children are emotional, psychological, economical, and religious, among others, and it is important to minimize these effects on children. Divorce also affects the personality, learning interests, and mental development of adolescents, as they still need the love and attention of both parents.What is the impact of stress on the immune system?

Stress has a significant impact on the immune system. It can alter immune functions and lead to immune responses that promote depressive- and anxiety-like behaviors. Different stressors can induce either inflammation or immune suppression, depending on the specific response required. Chronic stress can drive changes in microglia phenotype and increase inflammatory cytokine signaling, leading to synaptic plasticity deficits and impaired neurogenesis. Stress also affects the Th1/Th2 balance and immune mediators, making the body more vulnerable to external infections. Exposure to psychological stress is associated with the onset and exacerbation of diseases such as atopic dermatitis and autism spectrum disorder, potentially through the activation of mast cells and subsequent inflammation.What are the mechanisms by which stress affects the brain immune system?

Stress affects the brain immune system through various mechanisms. Chronic stress leads to reduced neurogenesis and altered synaptic plasticity, which are similar to the pathophysiology of psychiatric disorders. Microglia, a type of neuroimmune cell, play a critical role in regulating the neurobiology of stress. Chronic stress changes microglia phenotype, increases inflammatory cytokine signaling, and affects neuronal function, synaptic plasticity, and neurogenesis. Stress-induced immune responses, both in the periphery and the brain, contribute to depressive- and anxiety-like behaviors. Stress mobilizes myeloid cells to the brain, where they release cytokines and affect neuronal morphology and activity. Different stressors induce diverse immune responses, which can either promote inflammation or immune suppression. Stress is associated with changes in ligand-receptor interactions on the membranes of immune cells, and the orexinergic system mediates the brain's responses to stressors. The feedback between the peripheral immune system and the brain contributes to individual differences in the behavioral response to stress, and immune response to stress may contribute to mood-related disorders.What are the advantages of Neo4j in navigating through relationships?

Neo4j offers several advantages in navigating through relationships. Firstly, it provides a visual representation of relationships, allowing users to easily understand and analyze connections between individuals or components of data. This visual understanding helps in identifying commonalities and trends in relationships. Additionally, Neo4j enables efficient and intuitive navigation of complex many-to-many relationships, making it easier for users to explore and interact with the underlying data structure. Furthermore, Neo4j allows users to define filters and apply them to the relationships, providing a tailored and focused view of the data. Overall, Neo4j's visual representation, intuitive navigation, and customizable filtering capabilities make it a powerful tool for effectively navigating and analyzing relationships in various domains.What is the cyber philosophy?

Cyber philosophy refers to the study of the relationship between humans and technology in the context of cyberspace. It explores the impact of new technologies on ethical situations and the existential nature of individuals. The concept of cyber philosophy is closely related to the cyberization of objects and spaces, leading to the convergence of physical, social, thinking, and cyberspaces. It examines the human-machine relationship and the potential for subservient behavior towards machines, where humans become instruments for the use of digital resources. Cyber philosophy also challenges traditional philosophical theories, such as realism, and proposes a constructivist approach within the field of cybernetics. Additionally, it addresses the need for professional and corporate ethics in the field of cybersecurity, emphasizing the importance of raising awareness and providing education on cyber hygiene and security.