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Why inflammation happens? 

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Inflammation occurs as a normal physiological response to injury, infection, or other challenges to homeostasis . It is a protective mechanism that aims to eliminate the cause of damage, remove damaged cells, and initiate tissue healing and repair . Acute inflammation is a short-term, self-limiting response that helps control infections and promote wound healing . However, chronic inflammation can occur when the mission of acute inflammation is not accomplished, leading to ongoing oxidative stress and disease onset . Chronic inflammation can be caused by various factors such as persistent infection, chronic non-infectious diseases, aging, and chronic trauma . While inflammation is intended to benefit the body, an inflammatory response can go awry, resulting in collateral damage to healthy tissues and exacerbation of disease . Therefore, understanding the causes and mechanisms of inflammation is crucial for effective medical treatment and management .

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Inflammation can be caused by various factors such as blood clots, immune system disorders, infections, cancers, chemical exposures, physical injuries, or neurological conditions.
Book ChapterDOI
01 Jan 2022
Inflammation happens as a protective response to injury or infection, helping to eliminate the cause of injury and initiate tissue healing and repair.
Book ChapterDOI
01 Jan 2014
4 Citations
Inflammation happens as a reaction to tissue injury and is designed to eliminate the cause of damage and promote healing.
Inflammation happens as a normal physiological process to maintain homeostasis, repel foreign invaders, and initiate healing response, triggered by various environmental factors.
Inflammation happens as a protective response to invasion, injury, and other challenges to homeostasis, but chronic inflammation occurs when the mission is not accomplished.

Related Questions

What are the effects of inflammation on the brain?4 answersInflammation in the brain can have various effects. It can lead to redness, swelling, heat, pain, and loss of function, similar to the effects of inflammation in other parts of the body. In neuropsychiatric disorders, neuroinflammation can cause neuronal or glial atrophy or death, disruptions in neurotransmitter signaling, and cognitive and behavioral changes. Neuroimaging studies have shown potential disruptions in the choroid plexus and blood-brain barrier, which can affect the transfer of ions, molecules, toxins, and cells from the periphery into the brain. Systemic inflammation can also impact cerebral blood vessels, leading to impaired oxygen availability and disturbances in neurovascular coupling. These vascular changes and impaired oxygen availability may contribute to the long-term risk of neurodegenerative changes associated with chronic, systemic inflammation.
How does pain affect inflammation?3 answersPain affects inflammation in multiple ways. Inflammatory mediators can activate peripheral nociceptors, leading to pain. Changes in the responsiveness of nociceptive nerve endings can cause ongoing pain and lowered pain thresholds, resulting in hyperalgesia. Inflammation can stimulate angiogenesis, which can facilitate pain. Inflammatory processes in the peripheral and central nervous systems contribute to the development and maintenance of chronic pain. On the other hand, leukocytes release opioid peptides in inflamed tissue, counteracting the effects of inflammation and reducing pain. Macrophages and glial cells in the peripheral and central nervous systems can also promote pain resolution through the release of anti-inflammatory mediators and specialized pro-resolving mediators. Overall, pain and inflammation have a complex relationship, with inflammation contributing to pain sensitization and chronic pain, while pain can also influence the inflammatory process.
What specific bacteria that causes inflammation?3 answersSpecific bacteria that can cause inflammation include Helicobacter hepaticus, Proteobacteria, Pseudomonas aeruginosa, and certain subtypes of Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans, and Campylobacter rectus. These bacteria have been shown to induce chronic intestinal inflammation, inflammatory bowel disease, pulmonary inflammation, and extra-oral infections and inflammation. The degree of inflammation can be influenced by the specific composition of bacterial strains and their interactions with other bacteria. Additionally, the inflammatory response may be regulated by factors such as gut microbiota composition, immune response, and host genetic factors. Further research is needed to fully understand the mechanisms by which these bacteria induce inflammation and their role in various diseases.
What are different signs of inflammation?9 answers
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