scispace - formally typeset
Search or ask a question

Why is exon 6 chosen for this purpose? 

Exon
Exon trapping
Exonic splicing enhancer
Tandem exon duplication
Exon shuffling

Answers from top 8 papers

More filters
Papers (8)Insight
Open access•Journal Article•DOI
A subfragment of the β tropomyosin gene is alternatively spliced when transfected into differentiating muscle cells
Domenico Libri, J Marie, E Brody, M Y Fiszman 
25 Aug 1989-Nucleic Acids Research
31 Citations
We suggest that failure of exon 6A to splice to exon 6B is due to the existence of some structural constraints which lower the efficiency with which the intron between them is excised.
Journal Article•DOI
Analysis of exonic splicing enhancers in the mouse gonadotropin-releasing hormone (GnRH) gene
Jin Han, Jae Young Seong, Kyungjin Kim, Wolfgang Wuttke, Hubertus Jarry 
22 Feb 2001-Molecular and Cellular Endocrinology
9 Citations
While not excised by exon 2 alone, intron A was efficiently excised when exon 3 and/or exon 4 was combined with exon 2, suggesting the presence of exonic splicing enhancers (ESEs) in exons 3 and 4.
Open access•Journal Article•DOI
Antisense-mediated exon skipping: A versatile tool with therapeutic and research applications
Annemieke Aartsma-Rus, Gert-Jan B. van Ommen 
01 Oct 2007-RNA
284 Citations
This knowledge allows us to optimize therapeutic exon skipping, but also opens up a range of other applications for the exon skipping approach.
Open access•Journal Article•DOI
Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus.
Mark A. Glenn, Lucille Rainbow, Frédéric Auradé, Andrew J. Davison, Thomas F. Schulz 
01 Aug 1999-Journal of Virology
155 Citations
We also found evidence for an alternative use of exon 1.
Journal Article•DOI
The splicing determinants of a regulated exon in the axonal MAP tau reside within the exon and in its upstream intron.
Mei-Ling Wei, John Memmott, Gavin R. Screaton, Athena Andreadis 
15 Sep 2000-Molecular Brain Research
22 Citations
These results strongly suggest that factors binding immediately upstream of exon 6 are involved in regulation of this exon.
Journal Article•DOI
The splicing determinants of a regulated exon in the axonal MAP tau reside within the exon and in its upstream intron.
Mei-Ling Wei, John Memmott, Gavin R. Screaton, Athena Andreadis 
15 Sep 2000-Molecular Brain Research
22 Citations
They also lead to the conclusion that splicing of exon 6 is primarily governed by multiple branch points.
Journal Article•DOI
Expression of CD45 isoforms lacking exons 7, 8 and 10.
Elizabeth L. Virts, Diana S. Barritt, William C. Raschke 
16 Feb 1998-Molecular Immunology
25 Citations
Finally, these studies demonstrate that exon 10 is also used as an alternatively spliced exon.
Open access•Journal Article•DOI
Large exon size does not limit splicing in vivo
I T Chen, Lawrence A. Chasin 
01 Mar 1994-Molecular and Cellular Biology
33 Citations
We conclude that a limitation in exon size is not part of the exon definition mechanism.

Related Questions

What should 6g be?5 answers6G should be an extension of the vision of 5G, aiming to enable more ambitious scenarios in the future and incorporating visionary technologies for step changes in communication capabilities. The research efforts on 6G are already underway, with initiatives in various countries focusing on exploring the technical aspects and vision of 6G.
How much is an exon?6 answers
How much of the human genome is exons?4 answers
What are the possible benefits from having introns and exons in your DNA?4 answers
What are the possible benefits of having introns and exons in your DNA?2 answers
What percentage of human genome is Exon?3 answers

See what other people are reading

What are the most common genetic mutations associated with hypothyroidism?
5 answers
The most common genetic mutations associated with hypothyroidism include mutations in genes such as DUOX2, TPO, and TSHR. These mutations are frequently detected in patients with congenital hypothyroidism (CH) and play a significant role in the pathogenesis of the condition. Studies have shown that DUOX2 mutations, especially compound heterozygous mutations, exhibit a high detection rate in CH patients. Additionally, mutations in genes like TG, FOXE1, and PAX8 have also been implicated in thyroid dysgenesis, a primary cause of CH. Furthermore, genetic screening has revealed a variety of mutations in genes involved in thyroid hormone synthesis, emphasizing the genetic complexity underlying hypothyroidism.Alternative splicing of ABI3 and ABI5, substrates of SnRK2s, was observed following ABA treatment?
5 answers
Alternative splicing of ABI3 and ABI5, substrates of SnRK2s, was indeed observed following ABA treatment. Studies have shown that ABI3 undergoes alternative splicing to produce different isoforms with altered functions, affecting ABA signaling in both monocotyledons and dicotyledons. Additionally, ABA treatment significantly impacts the alternative splicing pattern of genes, leading to the generation of various isoforms, including alternative first exon (AFE) and alternative last exon (ALE) types. This splicing diversity contributes to the regulatory network of ABA signaling. The interaction between ABI3 and ABI5 is crucial, with specific isoforms of ABI3 showing differential activation of downstream genes and hypersensitivity to ABA during seed germination and root growth. These findings highlight the intricate role of alternative splicing in modulating ABA responses through ABI3 and ABI5.How is RNA editinginvolved in the airway epithelium integrity and pathogen defense?
5 answers
RNA editing plays a crucial role in maintaining airway epithelium integrity and pathogen defense. Studies have shown that altered microRNA editing, specifically A-to-I editing, in bronchial epithelial cells is associated with asthma severity. Additionally, alternative splicing of genes like CHRNA7 and CHRFAM7A, involved in the cholinergic anti-inflammatory pathway, affects the nature of transcripts generated, potentially impacting the body's defense mechanisms against tissue injury or infection. Furthermore, microRNAs have been identified as essential regulators of ion channels and transporters responsible for airway surface liquid (ASL) homeostasis, which is crucial for mucociliary clearance and host defense against inhaled pathogens. These findings highlight the intricate involvement of RNA editing mechanisms in maintaining airway epithelium integrity and enhancing the defense against pathogens.Amino acid substitutions in genetic variants of human serum albumin and in sequences inferred from molecular cloning
4 answers
Amino acid substitutions in genetic variants of human serum albumin have been extensively studied. Various variants like albumin Naskapi, Mersin, Adana, Mexico-2, and proalbumin Wu Yang exhibit specific amino acid changes, such as Lysine-372 to glutamic acid, aspartic acid-550 to glycine, and Arg-->His mutations. These substitutions are crucial in understanding the structural changes in albumin variants. Additionally, sequencing studies have shown that most variants result from single-point mutations, with some exceptions like Catania and Venezia, which involve chain-termination mutations. Discrepancies in amino acid sequences inferred from cDNA sequences are attributed to cloning artifacts rather than true polymorphisms. The distribution of point mutations in the albumin gene is nonrandom, often affecting charged amino acid residues on the protein surface.How can SNP mutations affect the expression and function of specific genes?
5 answers
Single Nucleotide Polymorphisms (SNPs) can impact gene expression and function by altering transcription factor binding sites, affecting splicing, translation, stability, and protein function. Regulatory SNPs (rSNPs) in non-coding regions and microRNAs can influence gene expression. Additionally, structural RNA SNPs (srSNPs) can affect splicing, translation, and protein structure. Studies show that SNPs near genes can lead to changes in expression levels and protein properties, especially in non-synonymous SNPs that alter amino acids. Furthermore, genetic variants can influence gene expression in specific tissues, highlighting the importance of considering tissue-specific effects when studying SNP-gene interactions. Overall, understanding how SNP mutations affect gene expression and function is crucial for unraveling the genetic basis of various diseases and traits.What are the current diagnostic methods for identifying early-onset obesity and endocrine dysfunction due to LEPR gene mutation?
5 answers
Current diagnostic methods for identifying early-onset obesity and endocrine dysfunction due to LEPR gene mutations involve genetic screening and clinical assessments. Genetic testing, such as next-generation sequencing of obesity-related genes like LEPR, LEP, MC4R, and POMC, is crucial. Clinical evaluations include assessing hormonal levels like FSH, LH, oestradiol, and testosterone, as well as leptin levels, BMI measurements, and detailed medical histories. Functional studies on identified LEPR variants are essential to determine their impact on leptin-mediated signaling, receptor expression, and dimerization. Early diagnosis through these methods is vital for personalized treatment options, including pharmacologic interventions like MC4R-agonists, to manage obesity and associated endocrine dysfunctions effectively.How is computational analyzes used to uncover misinfromation?
5 answers
Computational analysis plays a crucial role in uncovering misinformation by assessing various genetic mutations and decision-making processes. For instance, computational methods were utilized to evaluate the effects of missense mutations in the PTEN gene related to breast cancer and Cowden disease. Additionally, computational analysis was employed to study joint decision-making processes, considering factors like empathic understanding and common decision options. Furthermore, in the context of genetic variations, computational tools were used to identify weaker splicing motifs in exons of the CFTR gene, aiding in the classification of mutations as disease-causing or neutral. These examples highlight the diverse applications of computational analysis in uncovering misinformation across genetic studies and decision-making scenarios.What is exon in genes section?
5 answers
Exons are DNA regions transcribed into RNA and retained after introns are spliced out. Contrary to common misuse equating exons with protein-coding regions, only a minority of exonic sequences (<30% in humans) actually encode proteins. Exons play a crucial role in gene prediction, as they contain the coding regions responsible for amino acid sequences in proteins. Recent studies have shown that analyzing gene expression at the exon level, rather than the gene level, can enhance the detection of differentially expressed genes, with the exon-level approach showing improved accuracy and lower false discovery rates, especially when using the empirical Brown's aggregation method. Understanding the distinction between coding and non-coding exonic regions is essential for precise genetic and genomic analyses, emphasizing the significance of accurate terminology in sequencing approaches.What genetic mutations are most commonly associated with the development of breast cancer?
5 answers
Genetic mutations commonly associated with breast cancer development include mutations in genes like CCND1, ERBB2, CDK12, ADGRA2, ZNF703, FGFR1, KAT6A, POLB, COL1A1, AXIN2, ZNF217, GNAS, BRIP1, FGF3, FGF4, FGF19, Nf1, and Trps1. Additionally, mutations in mitochondrial tRNA genes such as tRNA Val G1606A, tRNA Ile A4300G, tRNA Ser (UCN) T7505C, tRNA Glu A14693G, and tRNA Thr G15927A have been linked to breast cancer development due to their impact on mitochondrial functions. Furthermore, somatic mutations in PIK3CA, particularly in exons 9 and 20, have been identified in a significant percentage of breast cancer cases, with associations to negative lymph node status. These genetic alterations play crucial roles in breast carcinogenesis and highlight potential targets for therapeutic interventions.What is the promer sequence for mRNA pp2a shsy5y cell?
5 answers
The promoter sequence for mRNA in SH-SY5Y cells involves neuron-specific characteristics with regard to both promoter activation and alternative splicing. In the context of neuroblastoma cell survival, P2Y receptors are expressed in SH-SY5Y cells, and purinergic receptor antagonism affects cell viability and alters P2 receptor expression. Additionally, the CITE-seq technique was used to characterize the transcriptome of SH-SY5Y cells, providing insights into gene expression profiles at the single-cell level. These studies collectively highlight the complexity of gene regulation and expression in SH-SY5Y cells, emphasizing the importance of understanding the molecular mechanisms underlying mRNA production in these neuroblastoma cells.Is there any studies on the brazilian population with ALS and the gene TBK1 ?
5 answers
Studies have been conducted on the Brazilian population with Amyotrophic Lateral Sclerosis (ALS) and the gene TBK1. One study reported a novel TBK1 mutation in a Brazilian ALS patient, highlighting the importance of genetic testing in this population. Another study emphasized the need for increased disease awareness in various medical specialties due to a high frequency of misdiagnoses observed in clinical practice among ALS patients in Brazil. Additionally, research on TBK1 variants in ALS patients of Chinese origin revealed the presence of likely pathogenic mutations, emphasizing the importance of genetic analysis in diverse populations to understand the genetic spectrum of ALS. These studies collectively contribute to enhancing our understanding of ALS and TBK1 mutations in the Brazilian and broader populations.