Topic
1,3-Dipolar cycloaddition
About: 1,3-Dipolar cycloaddition is a research topic. Over the lifetime, 5560 publications have been published within this topic receiving 98615 citations.
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TL;DR: In this paper, the Click chemistry inspired Huisgen 1,3-dipolar cycloaddition reaction in the presence of a Cu(I) catalyst was used to grow divergently grown dendrimers containing 1,4-triazole linkages.
Abstract: Dendrimers containing 1,4-triazole linkages between each generation were grown divergently via the Click chemistry inspired Huisgen 1,3-dipolar cycloaddition reaction in the presence of a Cu(I) catalyst. The monomeric unit (1-propargylbenzene-3,5-dimethanol) contained the alkyne functionality, while the core (1,2-bis(2-azidoethoxy)ethane) and growing dendrimers presented the azide groups necessary for this type of Click reaction. The first generation dendrimer was also functionalized with alkyne termini to demonstrate an alternative pathway allowed by this chemistry. Synthesis and characterization, with infrared (IR), 1H and 13C NMR spectroscopies, high-resolution mass spectrometry, gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA), are reported for these divergently grown dendrimers.
237 citations
TL;DR: In this paper, a monolayers of 11-azido-undecyl-siloxane were prepared on powdered silica and on silicon wafers by the substitution of 11bromo-, undecyl, and were subsequently coupled with three substituted acyclic acid derivatives.
Abstract: Monolayers of 11-azido-undecylsiloxane were prepared on powdered silica and on silicon wafers by the substitution of 11-bromo-undecylsiloxane and were subsequently coupled with three substituted ac...
235 citations
234 citations
TL;DR: This article surveys recent applications of Cu(I)-catalysed 1,3-dipolar cycloaddition of azides and alkynes in carbohydrate chemistry, highlighting developments in the preparation of simple glycoside and oligosaccharide mimetics, glyco-macrocycles, glycopeptides, Glyco-clusters and carbohydrate arrays.
Abstract: This article surveys recent applications of Cu(I)-catalysed 1,3-dipolar cycloaddition of azides and alkynes in carbohydrate chemistry, highlighting developments in the preparation of simple glycoside and oligosaccharide mimetics, glyco-macrocycles, glycopeptides, glyco-clusters and carbohydrate arrays.
230 citations
TL;DR: In this article, the intramolecular 1, 3-dipolar cycloaddition reaction of suitably functionalized 1,3-dipoles represents a general scheme for the synthesis of novel fused ring heterocycles.
Abstract: The intramolecular 1,3-dipolar cycloaddition reaction of suitably functionalized 1,3-dipoles represents a general scheme for the synthesis of novel fused ring heterocycles. Such reactions of a number of 1,3-dipoles are summarized and the general outline and potential analogies for these reactions noted. While the immediate aim of this review is to survey and correlate published work, it is hoped that general and specific points in need of study will be revealed and will stimulate further work in this fertile field.
230 citations