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7,12-Dimethylbenz[a]anthracene

About: 7,12-Dimethylbenz[a]anthracene is a research topic. Over the lifetime, 1717 publications have been published within this topic receiving 40892 citations.


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Journal ArticleDOI
TL;DR: Investigation of the effect of dietary Diosmin on IL-6/STAT-3 signaling in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis provides significant evidence that Diosmine prevents the development and progression of HBP carcinomas through the inhibition of IL- 6/STAT -3 signaling and its downstream events.

18 citations

Journal ArticleDOI
TL;DR: A significant reduction in the values of tumour incidence, tumour burden and the cumulative number of papillomas was observed in mice treated orally with the seed extract of Brassica compestris var sarason, continuously at peri and post initiational stages of papilomagenesis compared with the control groups.
Abstract: We report the chemopreventive property of an ethanolic extract of the seeds of Brassica compestris var sarason (mustard seed) on DMBA (7,12 dimethylbenz(a)anthracene induced skin papillomagenesis in male Swiss albino mice. A significant reduction in the values of tumour incidence, tumour burden and the cumulative number of papillomas was observed in mice treated orally with the seed extract of Brassica compestris var sarason, continuously at peri and post initiational stages of papillomagenesis compared with the control groups. The latency period in the experimental group significantly increased (11.3 ± 0.40 weeks) compared with the control group (7.8 ± 0.17). Copyright © 1999 John Wiley & Sons, Ltd.

18 citations

Journal ArticleDOI
TL;DR: It is clearly demonstrated that gramine treatment diminishes angiogenesis and induces apoptosis in hamster buccal pouch (HBP) carcinogenesis by modulating TGF-β signals.

18 citations

Journal ArticleDOI
TL;DR: A single subcutaneous injection of 7,12-dimethylbenz(a)anthracene in tricaprylin was given in the interscapular region to newborn Syrian golden hamsters and the induction of sub cutaneous sarcomas and of dermal melanocytomas was obtained.
Abstract: Summary A single subcutaneous injection of 7,12-dimethylbenz(a)anthracene in tricaprylin was given in the interscapular region to newborn Syrian golden hamsters. Doses of 1000, 200 and 100 μg were administered and tricaprylin treated and untreated controls were also observed. The induction of subcutaneous sarcomas and of dermal melanocytomas was obtained. In addition, a slight acceleration of the appearance of malignant lymphomas was found.

18 citations

Journal ArticleDOI
TL;DR: It is reported that the weak carcinogen benz[a]anthracene undergoes meso-anthracenic methylation by S-adenosyl-L-methionine (SAM), in the presence of a rat liver cytosol preparation, in vitro, to form DMBA and presumably the moderately active carcinogens 7,12-dimethylbenz[a]-anthracenes and 12-methylbenz,[a] anthracene.

18 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20236
202215
202121
202018
201912
201823