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7,12-Dimethylbenz[a]anthracene
About: 7,12-Dimethylbenz[a]anthracene is a research topic. Over the lifetime, 1717 publications have been published within this topic receiving 40892 citations.
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TL;DR: None of the parameters demonstrated any correlation with growth rate, although there were many coordinated biochemical changes in 3: isocitrate dehydrogenase and hexokinase activities and triglyceride content.
Abstract: Mammary tumors induced by 7,12-dimethylbenz(a)-anthracene were divided into slow- and fast-growing neoplasms on the basis of growth rate. Biochemical and histological evaluation was performed on each group and the data were compared. Of the 21 different parameters examined, significant differences were found in 3: isocitrate dehydrogenase and hexokinase activities and triglyceride content. None of the parameters demonstrated any correlation with growth rate, although there were many coordinated biochemical changes.
17 citations
TL;DR: The finding that adduct formation in microsomes from Sudan III-, phenobarbital- and dexamethasone-treated rats could be inhibited by the isoenzyme-selective inhibitors alpha-naphthoflavone, metyrapone and troleandomycin, respectively was supported.
17 citations
TL;DR: The effect of a peptide prepared from corn gluten meal by proteolysis with alkaline protease on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumor progression were investigated in female Sprague-Dawley rats and total number and total weight of tumors were greater in the CAS group compared with 5-CP, 10-CP or AA groups.
17 citations
TL;DR: The chemopreventive potential of genistein+daidzein in combination is probably due to their antilipid peroxidative efficacy and modulatory effect on phase I and phase II detoxification cascade during DMBA induced mammary carcinogenesis.
Abstract: The chemopreventive potential of two major soy isoflavones, genistein and daidzein, in mammary carcinogenesis remains enigmatic. The aim of the present study was to investigate the chemopreventive potential of orally administered genistein, daidzein and genistein+daidzein in 7,12-dimethylbenz[a]anthracene (DMBA) induced mammary carcinogenesis in Sprague-Dawley rats. The chemopreventive potential was assessed by monitoring the tumor incidence and tumor volume as well as by analyzing the status of biochemical markers (17beta-estradiol (E2)), enzymatic and non-enzymatic antioxidants and phase I and phase II detoxification enzymes) during DMBA-induced mammary carcinogenesis. A single subcutaneous injection of DMBA (25 mg rat(-1)) in the mammary gland developed mammary carcinoma in female Sprague-Dawley rats. Oral administration of genistein (20 mg kg(-1) b.wt.), daidzein (20 mg kg(-1) b.wt.) and genistein+daidzein (20 mg+20 mg kg(-1) b.wt.) to DMBA treated rats significantly prevented the tumor incidence and tumor volume as well as brought back the status of above said biochemical variables. Genistein and daidzein in combination have shown pronounced chemopreventive potential than either as genistein or daidzein alone. The present study revealed the chemopreventive potential of genistein+daidzein in combination during DMBA induced mammary carcinogenesis. The chemopreventive potential of genistein+daidzein is probably due to their antilipid peroxidative efficacy and modulatory effect on phase I and phase II detoxification cascade during DMBA induced mammary carcinogenesis.
17 citations
TL;DR: ERBB2 is required for the normal healing of skin wounds and for the progression of tumors during skin chemical carcinogenesis in mice and may be a promising target for inhibiting human nonmelanoma skin cancer progression.
17 citations