scispace - formally typeset
Search or ask a question
Topic

7,12-Dimethylbenz[a]anthracene

About: 7,12-Dimethylbenz[a]anthracene is a research topic. Over the lifetime, 1717 publications have been published within this topic receiving 40892 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: In this paper, the effect of pregnancy and lactation on growth of mammary tumor induced by 7,12-Dimethylbenz(a)anthracene (DMBA) was investigated.
Abstract: Effect of Pregnancy and Lactation on Growth of Mammary Tumours Induced by 7,12-Dimethylbenz(a)anthracene (DMBA)

61 citations

Journal ArticleDOI
TL;DR: Evidence is provided that alliinase may be important for the formation of allyl sulfur compounds that contribute to a depression in DMBA metabolism and bioactivation.
Abstract: The present studies compared the impact of heating, either by microwave or convection oven, on the ability of garlic to reduce the in vivo bioactivation of 7,12-dimethylbenz(a)anthracene (DMBA) in 55-d-old female Sprague-Dawley rats. In study 1, rats were fed a semipurified casein-based diet and treated by gastric gavage thrice weekly for 2-wk with crushed garlic (0.7 g in 2 mL corn oil) or the carrier prior to DMBA treatment (50 mg/kg body weight). Providing crushed garlic reduced by 64% (P < 0.05) the quantity DMBA-induced DNA adducts present in mammary epithelial cells compared to controls. In study 2, microwave treatment for 60 s, but not 30 s, decreased (P < 0.05) the protection provided by garlic against DMBA-induced adduct formation. In study 3, allowing crushed garlic to stand for 10 min prior to microwave heating for 60 s significantly (P < 0.05) restored its anticarcinogenic activity. Microwave heating of garlic for 30 s resulted in a 90% loss of alliinase activity. Heating in a convection oven (study 4) also completely blocked the ability of uncrushed garlic to retard DMBA bioactivation. Study 5 revealed that providing either 0.105 micromol diallyl disulfide or S-allyl cysteine by gastric gavage thrice weekly for 2 wk was effective in retarding DMBA bioactivation but isomolar alliin was not. These studies provide evidence that alliinase may be important for the formation of allyl sulfur compounds that contribute to a depression in DMBA metabolism and bioactivation.

60 citations

Journal ArticleDOI
TL;DR: Data from this pilot study suggest that in addition to being effective against colon cancer, InsP6 +/- Ins may be protective against mammary carcinoma as well; additional studies are however warranted.

60 citations

Journal ArticleDOI
TL;DR: Eugenol has a potent protective effect against DMBA‐induced genotoxicity, presumably through the suppression of the DMBA activation and the induction of its detoxification.

60 citations


Network Information
Related Topics (5)
Cell culture
133.3K papers, 5.3M citations
82% related
Cell growth
104.2K papers, 3.7M citations
81% related
Apoptosis
115.4K papers, 4.8M citations
80% related
Cell cycle
81.7K papers, 3.3M citations
80% related
Cancer cell
93.4K papers, 3.5M citations
79% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20236
202215
202121
202018
201912
201823