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7,12-Dimethylbenz[a]anthracene

About: 7,12-Dimethylbenz[a]anthracene is a research topic. Over the lifetime, 1717 publications have been published within this topic receiving 40892 citations.


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Journal ArticleDOI
TL;DR: Betel leaf extract at the dose levels used in the present study did not affect the body weight gain among rats and no appreciable degree of inhibition of tumor growth was noticed.

36 citations

Journal ArticleDOI
TL;DR: A very good inverse correlation was found between the potential life span of a species and the apparent capacity of its cultured fibroblasts to activate DMBA.

36 citations

Journal Article
TL;DR: It is demonstrated that metallothionein acts as an endogenous defensive factor against DMBA-induced skin tumorigenesis and shows proliferative activity, as shown by proliferative cell nuclear antigen staining.
Abstract: To investigate a possible involvement of metallothionein (MT) in chemical carcinogenesis, MT-I and MT-II gene-deficient [MT (-/-)] transgenic mice and wild-type [MT (+/+)] control mice were topically applied at a single dose of 100, 250, 500, or 1000 µg of 7,12-dimethylbenz[ a ]anthracene (DMBA) on the dorsal skin and thereafter compared. After 14 weeks of DMBA treatment, the skin tumor occurred in MT (-/-) mice only and in a dose-dependent manner, whereas no change was observed in MT (+/+) mouse skin given the same DMBA treatment. The tumor cells showed proliferative activity, as shown by proliferative cell nuclear antigen staining. These results demonstrate that MT acts as an endogenous defensive factor against DMBA-induced skin tumorigenesis.

36 citations

Journal ArticleDOI
TL;DR: It is shown that cells with a high expression level of WT1 tended to develop into leukemia and that WT1 contributed to leukemogenesis in the late stage, suggesting that the expression ofWT1 plays an important role in cell proliferation and in maintaining the viability of some leukemia cells.
Abstract: The Wilms'-tumor gene WT1 may have a different function from a tumor-suppressor gene in some leukemias. Using the 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat leukemia system, we examined whether WT1 expression was involved during leukemogenesis, since this model enabled us to analyze cells altered by DMBA at various stages of leukemogenesis. By the semi-quantitative reverse-transcriptase polymerase chain reaction(RT-PCR) method, WT1 expression was detected in 15 (71%) of 21 DMBA-induced erythroblastic leukemias. Among 15 WT1-expressing leukemias, GATA-1, which is an erythroid-specific transcription factor and might regulate WT1 expression, was also expressed in 13 cases (p < 0.05). On the other hand, WT1 expression was not detected in any normal or early pre-leukemic rats and was detected in 1 of 8 rats in late pre-leukemic stages. These results showed that cells with a high expression level of WT1 tended to develop into leukemia and that WT1 contributed to leukemogenesis in the late stage, suggesting that the expression of WT1 plays an important role in cell proliferation and in maintaining the viability of some leukemia cells. Int. J. Cancer 72:696–699, 1997. © 1997 Wiley-Liss, Inc.

36 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20236
202215
202121
202018
201912
201823