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Showing papers on "Acacetin published in 1987"


Journal ArticleDOI
TL;DR: An investigation of the South African tree Combretum caffrum (Combretaceae) for antineoplastic constituents was conducted by employing the astrocytoma bioassay (9ASK) and a substance designated combretastatin was isolated and found to display significant astroCyte reversal and murine P-388 lymphocytic leukemia cell growth inhibition.
Abstract: An investigation of the South African tree Combretum caffrum (Combretaceae) for antineoplastic constituents was conducted by employing the astrocytoma bioassay (9ASK). By this approach and a combination of solvent partition, steric exclusion, and adsorption chromatographic procedures, a substance designated combretastatin [1a] was isolated and found to display significant (71-90% astrocyte reversal at 1-100 micrograms/ml dose levels) astrocyte reversal and murine P-388 lymphocytic leukemia (PS) cell growth inhibition (ED50 0.011 micrograms/ml). The structure of (-)-combretastatin was elucidated by X-ray crystal structure analysis and confirmed by total synthesis. The absolute configuration at C-10 was assigned the R-configuration on the basis of Horeau esterification techniques. Other prominent, albeit PS-inactive, constituents were found to be 3,3',4'-tri-O-methylellagic acid [2] and acacetin [3].

126 citations


Journal ArticleDOI
TL;DR: In this article, a sesquiterpene lactone septuplinolide was shown to be a 7,8β-lactonized eudesmanolide.

14 citations


Journal ArticleDOI
TL;DR: In this article, 14 medicinal plants were screened for determining inhibitory activities on monoamine oxidase B. The extracts of Artemisia Messer-Schmidtiana (herba), chrysanthemum indicum (flos),Ericibe obtusifolia (radix et rhizoma) andSophora japonica(flos) strongly inhibited the enzyme.
Abstract: Fourteen kinds of medicinal plants were screened for determining inhibitory activities on monoamine oxidase B. The extracts ofArtemisia Messer-Schmidtiana (herba),Chrysanthemum indicum (flos),Ericibe obtusifolia (radix et rhizoma) andSophora japonica (flos) strongly inhibited the enzyme. Among them, Chrysanthemi flos was chosen for elucidating its active principles, and some flavonoids were isolated and identified as acacetin (I), 5,7-dihydroxy chromone (II), diosmetin (III), apigenin (IV), eriodictyol (V) and luteolin (VI). IC50-dihydroxy chromone (II), diosmetin (III), apigenin (IV), eriodictyol (V) and luteolin (VI). IC50 were determined as following: I, 2.46; II, 0.19; III. 2.11mM, and the others showed weak inhibition.

11 citations


Journal ArticleDOI
TL;DR: Tetrahydroxy-6methoxyflavanone has been isolated for the first time from Eupatorium subhastatum besides acacetin, hispidulin, eupato.

10 citations