Topic
Acacetin
About: Acacetin is a research topic. Over the lifetime, 442 publications have been published within this topic receiving 10458 citations. The topic is also known as: 5,7-Dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone & Linarigenin.
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Journal Article•
TL;DR: The flowers of Buddleia officinalis Maxim have been used to cure eye inflammation in China and eight flavonoid compounds were isolated from them, except linarin and acacetin, which were identified as 5,7-dihydroxy-4'-O-methoxyflavone-7-O-alpha-L-rhamnopyranosyl and named neobudofficide.
Abstract: The flowers of Buddleia officinalis Maxim have been used to cure eye inflammation in China. Eight flavonoid compounds were isolated from them. Their structures were characterized as acacetin (1), apigenin (2), luteolin (3), neobudofficide (4), linarin (acaciin 5), luteolin-7-O-rutinoside (6), luteolin-7-O-glucoside (7) and cosmosiin (8), on the basis of chemical and spectral evidences. The new compound 4 was identified as 5,7-dihydroxy-4'-O-methoxyflavone-7-O-alpha-L-rhamnopyranosyl (1-->2)-[alpha-L-rhamnopyranosyl (1-->6)]-beta-D-glucopyranoside and named neobudofficide. All the compounds were isolated from B. officinalis for the first time, except linarin and acacetin.
9 citations
TL;DR: The chemical constituents of the whole plants of Pedicularis densispica were isolated by various chromatographic methods and their structures were determined by chemical evidences and spectral data.
Abstract: OBJECTIVE To study the chemical constituents of the whole plants of Pedicularis densispica. METHOD The chemical constituents were isolated by various chromatographic methods and their structures were determined by chemical evidences and spectral data. RESULT Ten compounds were isolated and identified as acacetin (1), apigenin-7-0-beta-glucopyranoside (2), kaempferol-3,7-O-alpha-dirhamnopyranoside (3), scutellarein-7-0-beta-glucopyranoside (4), chrysoeriol-7-O-beta-glucopyranoside (5), pedicutricone A (6), dearabinosyl pneumonanthoside (7), salidroside (8), darendoside B (9), and maltol-beta-D-glucopyranoside (10). CONCLUSION These compounds were isolated from the titled plant for the first time. Except compounds 6 and 8, the others were obtained for the first time from the genus Pedicularis.
9 citations
TL;DR: The RP-HPLC method is quick, simple and repeatable for simultaneous determination of quercetin, luteolin, apigenin and acacetin in Flos Chrysanthemi Indici.
Abstract: Objective To develop a RP-HPLC method for the determination of quercetin, luteolin, apigenin and acacetin in Flos Chrysanthemi indici. Method An Eclipse XDB-C18 column (4.6 mm x 250 mm, 5 microm) was used at 25 degrees C with the mobile phases of methanol-0.2% phosphatic acid in a gradient manner. The flow rate was set at 1.0 mL x min(-1). The detection wavelength was 350 nm. Result The linear response ranged from 1.02-20.48 mg x L(-1) for quercetin (r = 0.9994, n = 5), 1.03-20.54 mg x L(-1) for luteolin (r = 0.9992, n = 5), 1.12-22.40 mg x L(-1) for apigenin (r = 0.9995, n = 5), 1.01-20.22 mg x L(-1) for acacetin (r = 0.9998, n = 5), respectively. Recoveries were 101.3% with RSD 1.3% for quercetin, 100.62% with RSD 1.4% for luteolin, 98.42% with RSD 1.7% for apigenin and 99.02% with RSD 0.8% for acacetin. A significant difference (alpha = 0.01) among the contents of four flavonoids and total flavonoids was found. Conclusion The method is quick, simple and repeatable for simultaneous determination of quercetin, luteolin, apigenin and acacetin in Flos Chrysanthemi Indici.
9 citations
TL;DR: The coupling of glucuronidation and efflux transport was probably the primary reason for the low bioavailability of acacetin.
Abstract: To determine the mechanism responsible for acacetin glucuronide transport and the bioavailability of acacetin. Area under the curve (AUC), clearance (CL), half-life (T1/2) and other pharmacokinetic parameters were determined by the pharmacokinetic model. The excretion of acacetin glucuronides was evaluated by the mouse intestinal perfusion model and the Caco-2 cell model. In pharmacokinetic studies, the bioavailability of acacetin in FVB mice was 1.3%. Acacetin was mostly exposed as acacetin glucuronides in plasma. AUC of acacetin-7-glucuronide (Aca-7-Glu) was 2-fold and 6-fold higher in Bcrp1 (−/−) mice and Mrp2 (−/−) mice, respectively. AUC of acacetin-5-glucuronide (Aca-5-Glu) was 2-fold higher in Bcrp1 (−/−) mice. In mouse intestinal perfusion, the excretion of Aca-7-Glu was decreased by 1-fold and 2-fold in Bcrp1 (−/−) and Mrp2 (−/−) mice, respectively. In Caco-2 cells, the efflux rates of Aca-7-Glu and Aca-5-Glu were significantly decreased by breast cancer resistance protein (BCRP) inhibitor Ko143 and multidrug resistance protein 2 (MRP2) inhibitor LTC4. The use of these inhibitors markedly increased the intracellular acacetin glucuronide content. BCRP and MRP2 regulated the in vivo disposition of acacetin glucuronides. The coupling of glucuronidation and efflux transport was probably the primary reason for the low bioavailability of acacetin.
9 citations
Journal Article•
TL;DR: From the flowers of Hemisteptia lyrata Bunge, two flavonoids, apigenin and acacetin, were isolated and appeared to inhibit the polyphenol oxidase activity of tyrosinase in a competitive manner.
Abstract: From the flowers of Hemisteptia lyrata Bunge, two flavonoids, apigenin (1) and acacetin (2), were isolated. Their structures were established by UV, one- and two-dimensional NMR, and mass spectroscopic methods. Apigenin showed significant inhibition against mushroom tyrosinase with an IC_50 value of 4.56㎍·ml^-1, and appeared to inhibit the polyphenol oxidase activity of tyrosinase in a competitive manner (K_1=2.5×10 exp (-5) M) when L-tyrosine was used as a substrate, but did not inhibit the melanin production of Streptomyces bikiniensis.
8 citations