Topic
Acacetin
About: Acacetin is a research topic. Over the lifetime, 442 publications have been published within this topic receiving 10458 citations. The topic is also known as: 5,7-Dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone & Linarigenin.
Papers published on a yearly basis
Papers
More filters
Patent•
03 Feb 2014
TL;DR: Water-soluble derivatives and/or prodrugs of acacetin are described in this article, which can be used as cardioprotection agents against myocardial infarction induced by ischemia-reperfusion.
Abstract: Water-soluble derivatives and/or prodrugs of acacetin are described herein. The compounds can be used as cardioprotection agents against myocardial infarction induced by ischemia-reperfusion. In one embodiment the compounds are used to treat ischemic cardiac diseases. In the preferred embodiment, the compounds are used to treat and/or prevent myocardial infarction in humans.
4 citations
TL;DR: Nine flavonoids were isolated and identified as luteolin-4'-O-beta-D-glucoside, acacetin, rutin, quercetin, and Isorhamnetin from Lysimachia paridiformis var.
Abstract: Nine flavonoids were isolated and identified as luteolin (1), luteolin-4'-O-beta-D-glucoside (2), acacetin-7-O-beta-D-glucoside (3), rutin (4), acacetin (5), quercetin (6), quercetin-3-O-beta-D-glucoside (7), kaempferol-3-O-beta-D-glucoside (8), Isorhamnetin-3-O-beta-D-glucoside(9) from Lysimachia paridiformis var. stenophylla, and all these compounds were isolated from this plant for the first time.
4 citations
TL;DR: It is demonstrated that acacetin induces not only apoptotic cell death via activation of Bak, loss of Δψ, and activation of the mitochondrial caspase cascade, but also cytoprotective autophagy resulting from suppression of the Akt-mTOR pathway.
Abstract: Exposure of Jurkat T cell clone (J/Neo cells) to acacetin (5,7-dihydroxy-4'-methoxyflavone), which is present in barnyard millet (Echinochloa esculenta (A. Braun)) grains, caused cytotoxicity, enhancement of apoptotic sub-G1 rate, Bak activation, loss of mitochondrial membrane potential (Δψ), activation of caspase-9 and caspase-3, degradation of poly(ADP-ribose) polymerase, and FITC-Annexin V-stainable phosphatidylserine exposure on the external surface of the cytoplasmic membrane without accompanying necrosis. These apoptotic responses were abrogated in Jurkat T cell clone (J/Bcl-xL) overexpressing Bcl-xL. Under the same conditions, cellular autophagic responses, including suppression of the Akt-mTOR pathway and p62/SQSTM1 down-regulation, were commonly detected in J/Neo and J/Bcl-xL cells; however, formation of acridine orange-stainable acidic vascular organelles, LC3-I/II conversion, and Beclin-1 phosphorylation (Ser-15) were detected only in J/Neo cells. Correspondingly, concomitant treatment with the autophagy inhibitor (3-methyladenine or LY294002) appeared to enhance acacetin-induced apoptotic responses, such as Bak activation, Δψ loss, activation of caspase-9 and caspase-3, and apoptotic sub-G1 accumulation. This indicated that acacetin could induce apoptosis and cytoprotective autophagy in Jurkat T cells simultaneously. Together, these results demonstrate that acacetin induces not only apoptotic cell death via activation of Bak, loss of Δψ, and activation of the mitochondrial caspase cascade, but also cytoprotective autophagy resulting from suppression of the Akt-mTOR pathway. Furthermore, pharmacologic inhibition of the autophagy pathway augments the activation of Bak and resultant mitochondrial damage-mediated apoptosis in Jurkat T cells.
4 citations
TL;DR: In this article, a liquid phase one-step synthesis of acacetin from ethyl 3-(4-methoxyphenyl)-3-oxopropionate and phloroglucinol using PEG 1000 as solvent was examined.
Abstract: In this work liquid phase one-step synthesis of acacetin from ethyl 3-(4-methoxyphenyl)-3-oxopropionate and phloroglucinol using PEG 1000 as solvent was examined. Heating of the reaction mixture was done with 915 MHz and 2.45 GHz microwaves at atmospheric pressure. The demethylation of the obtained acacetin using HBr at reflux led to the formation of apigenin. In view of a possible scale-up, the reaction conditions under 915 MHz microwaves were optimized to obtain high yields of acacetin. The energy required to convert phloroglucinol in acacetin was also estimated and used to calculate the total microwave power required for scaling up the process by a factor of 100. This method is an easier and cleaner synthesis for large scale preparation of flavones with good yields and purity.
4 citations
Journal Article•
TL;DR: In this article, apigenin, acacetin, tilianin, kaempferol and kaempeferol-3-O-L-rhamnoside have been isolated from the herb Saussurae stella Maxim and superoxide anion scavanging and lipid peroxidation inhibitory activities of these flavonoids are reported.
Abstract: Flavonoids apigenin, acacetin, tilianin, kaempferol and kaempferol-3-O-L-rhamnoside have been isolated from the herb Saussurae stella Maxim and superoxide anion scavanging and lipid peroxidation inhibitory activities of these flavonoids are reported.
4 citations