Topic
Acacetin
About: Acacetin is a research topic. Over the lifetime, 442 publications have been published within this topic receiving 10458 citations. The topic is also known as: 5,7-Dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone & Linarigenin.
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TL;DR: In this article, the chemical constituents from the chloroform and ethyl acetate fractions of ethanol extract from Hemistepta lyrata were elucidated on the basis of chemical and spectroscopic methods, including MS, 1D and 2D NMR spectral techniques.
Abstract: Objective:To investigate the chemical constituents from the chloroform and ethyl acetate fractions of ethanol extract from Hemistepta lyrata.Method: The compounds were isolated by silica gel chromatography,ODS chromatography,Sephadex LH-20 chromatography,and preparative HPLC,and their structures were elucidated on the basis of chemical and spectroscopic methods,including MS,1D and 2D NMR spectral techniques.Result:Eight flavonoids were isolated from the chloroform and ethyl acetate fractions of ethanol extract from H.lyrata,and were identified as acacetin(1),cirsimaritin(2),apigenin(3),kaempferol(4),kaempferol-3-O-β-D-glucopyranoside(5),kaempferol-3-O-β-D-glucopyranoside(6),kaempferol-3-O-α-L-rhamnopyranosyl-(1 →6)-β-D-glucopyranoside(7),and acacetin-7-O-α-L-rhamnopyranosyl-(1 →6)-β-D-glucopyranoside(8).Conclusion: This is the first report of the isolation of 5 from Hemistepta genus.
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TL;DR: The ethyl acetate extract and compounds 6, 10, 12 and 18 at the concentration of 0.
Abstract: Objective To study the chemical components from the leaves of Fatsia japonica and their antitumor activities in vitro. Methods All compounds were separated and purified by column chromatography over silica gel, Sephadex LH-20 and preparative HPLC. Their structures were identified by physical and chemical properties and spectral methods including 1H-NMR and 13C-NMR. Antitumor assay was measured by MTT method. Results 18 compounds were isolated and identified as palmitic acid (1), β-hydroxypropiovanillone (2), adenosine (3), β-sitosterol (4), daucosterol (5), oleanolic acid (6), echinocystic acid (7), betulinic acid (8), hederagenin(9), hederagenin-3-O-α-L-rhamnopyranosyl(1-->2)-α-L-arabinopyranoside(10), acacetin(11), quercetin(12), quercetin-3-O-β-D-glucopyranoside(13), isovitexin(14), isovitexin-7-O-glucoside(15), astragalin(16), methylpluviatolide(17), and syringaresinol-4-O-β-D-glucopyranoside(18). Conclusion All compounds are isolated from the leaves of Fatsia japonica for the first time except compound 1. The ethyl acetate extract and compounds 6, 10, 12 and 18 at the concentration of 0. 5 mg/mL showed inhibitory effect against the proliferation of colon cell line A549 with the inhibitory rate over 90% in vitro.
2 citations