Acacetin

About: Acacetin is a research topic. Over the lifetime, 442 publications have been published within this topic receiving 10458 citations. The topic is also known as: 5,7-Dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone & Linarigenin.

Composition for preventing and treating breast cancer comprising acacetin

Abstract: A composition for preventing and treating the breast cancer, which contains an acacetin as an active ingredient is provided to reduce Bcl-2 expression, increase Bax and Bcl-2 and induce the apoptosis of MCF-7 cell which is a breast cancer cell. A composition for preventing and treating breast cancer cell comprises 25-200 muM of acecatin (5,7-dihydroxy-4'-methoxylflavon). The acecatin induces the activation of caspase, loss of mitochondria membrane potential, oxygen free radical generation, and the activation of stress-activated protein kinase/c-Jun NH-4 terminal kinase 1/2(SAPK/JNK1/2). The composition is administered through oral, mucous membrane (nasal cavity, sublingual, vagina, or rectum), perenteral (hypodermic and vein), topical (eye), transdermal or transcutaneous. The composition is used in a form of tablet, caplet, capsule, cachets, lozenges, powder, suppository, aerosol, gel, suspension, or elixir.

Quantitative determination of contents of flavone glycosides in Chrysanthemum morifolium

Abstract: Object To determine the amount of acacetin 7 O β D glucoside and apigenin 7 O β D glucoside in Chrysanthemum morifolium Ramat from different localities Methods By the use of HPLC Results The contents of acacetin 7 O β D glucoside in Boju 1, Chuju 2, Gongju 3 and Hangju 4 were 0 082 6% ～0 124 9%, 0 015 7% and 0 033 5% respectively; the contents of apigenin 7 O β D glucoside in Chuju, Boju, Gongju and Hangju were 0 012 6%, 0 027 4%, 0 117 7% and 0 587 7% respectively Conclusion The contents of the two flavone glycoside in C morifolium from different localities were markedly different

Determination of acacetin in Xiangjuganmao Keli (no sweet) by HPLC

Abstract: OBJECTIVE To establish a method for the determination of acacetin in Xiangjuganmao Keli (no sweet). METHODS Acacetin in powdered herb was extracted by ultrasonator with methanol and was hydrolyzed with hydrochloric acid. Separation was accomplished on an ODS reversed phase column (5 microm, 4.6 x 250 mm) with a mobile phase of methanol-water-acetic acid(350: 150: 2). The detective wavelength was at 340 nm. RESULTS The method was accurate, the results were stable and reproducible. The linear range of calibration cure was within the concentration of 2.00 - 10.00 microg/ml (r = 0.9998). The average extraction recovery was 99.9% (n = 6), RSD = 0.41% (n = 6). CONCLUSION The method is simple, convenient, sensitive, and reproducible for quality control of Xiangjuganmao Keli (no sweet).

Blainvillea rhomboidea : constituintes químicos e atividade citotóxica

Abstract: the ethanol extract from the aerial parts of Blainvillea rhomboidea (Asteraceae) resulted in the isolation and characterization of 8β-tigloyloxy-grazielia acid, together with the flavonoids derrone, acacetin, luteolin and luteolin 7-methyl ether, and p-(1-methylethan-1-ol)-phenol. The structures of all compounds were determined by spectroscopic methods (1H and 13C NMR and HREIMS) and comparison with published spectral data. The flavonoids luteolin and 7-O-metyl-luteolin, isolated from the active dichloromethane fraction, showed moderate cytotoxic activity.

Acacetin Alleviates Listeria monocytogenes Virulence Both In Vitro and In Vivo via the Inhibition of Listeriolysin O.

Abstract: Listeria monocytogenes is a ubiquitous Gram-positive foodborne pathogen that is responsible for listeriosis in both humans and several animal species. The bacterium secretes a pore-forming choleste...