Topic
Acridine
About: Acridine is a research topic. Over the lifetime, 3003 publications have been published within this topic receiving 48814 citations. The topic is also known as: Akridin & 2,3-benzoquinoline.
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TL;DR: The proposed structural change is compatible with the normal restrictions on bond lengths, angles, and non-bonded contacts, and maintenance of the hydrogen- bonded base pairs perpendicular to the axis of the molecule.
2,046 citations
657 citations
TL;DR: 4Muller, H. J., Drosophila Info.
Abstract: 4Muller, H. J., Drosophila Info. Serv., 22, 73-74 (1948). 5 Brosseau, G. E., Jr., and D. L. Lindsley, Drosophila Info. Serv., 32, 116 (1958). 6 Lindsley, D. L., and L. Sandler, Genetics, 43, 547-563 (1958). 7Personal communication. 8 Oksala, T. A., Cold Spring Harbor Symposia Quant. Biol., 23, 197-210 (1958). 9 Sandler, L. M., and E. Novitski, Genetics, 41, 189-193 (1956). 10 Bridges, C. B., Trudy po Dinemike Razvitiia, 10, 463-474 (1935). 11 Hannah, A., Advances in Genet., 4, 87-121 (1951).
454 citations
TL;DR: While intercalation seems to be prerequisite for mutagenicity of the insertion-deletion type, the acridine structure is not essential, nor are all intercalating molecules mutagenic.
Abstract: A number of independent critical structural parameters, which have been determined by studies on sedimentation, low angle X-ray scattering, flow dichroism, flow-polarized fluorescence, and chemical reactivity, provide the evidence for intercalation of the acridines between two otherwise sequential base pairs, and require the rejection of various alternative hypotheses. The binding requires a local untwisting and extension of the double helix, which is found to be compatible with the normal structural and bonding parameters. The expectation of a substantial alteration in the chemical reactivity of intercalated molecules because of their inaccessibility to electrophilic attack has been verified by reaction rate studies. Study of the relation between viscosity enhancement in dilute DNA solutions and intercalation has been extended using very low shear viscometry. The results agree with the earlier measurements in that the enhancement is observed with the binding of intercalatable cations, while others yield a slight diminution. A pronounced stabilization of the double helix is found, corresponding to a substantially raised thermal transition temperature. Intercalation into polyribonucleotide complexes formed between poly A and poly U renders the double helix substantially more stable than the triple. While intercalation seems to be prerequisite for mutagenicity of the insertion-deletion type, the acridine structure is not essential, nor are all intercalating molecules mutagenic.
357 citations
TL;DR: The UV/H2O2-induced degradation of carbamazepine, a worldwide used antiepileptic drug, recently found as contaminant in many municipal sewage treatment plant effluents and other aquatic environments, is investigated to support the importance of prolonged oxidation treatments to ensure complete degradation of aromatic intermediates.
345 citations