Topic
Acyl-CoA
About: Acyl-CoA is a research topic. Over the lifetime, 527 publications have been published within this topic receiving 25134 citations. The topic is also known as: Acyl Coenzyme A.
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TL;DR: DGAT2 can utilize diacylglycerol generated by MGAT2 for TG synthesis, suggesting that the interaction of DGAT2 and MGat2 serves to channel lipid substrates efficiently for TG biosynthesis.
53 citations
TL;DR: It is concluded that adiponectin induces an activation of AMPK in beta cells, which inhibits their cataplerosis of glucose-carbon to lipids.
53 citations
TL;DR: A marked reduction in myocardial CoA content in pressure-overload hypertrophy is established and its precursor, pantothenic acid, were unaltered.
Abstract: Changes in the total content and acylation state of coenzyme A (CoA) and carnitine in the heart result in alterations in fatty acid metabolism that may be associated with ventricular dysfunction. The present study was undertaken to determine whether abnormal myocardial CoA and carnitine metabolism occur in pressure-overload hypertrophy and congestive heart failure. Right ventricular hypertrophy was induced in cats by pulmonary artery (PA) banding. Total tissue CoA was reduced by 50% in the hypertrophied right ventricle and 25% in the nonhypertrophied left ventricle of PA-banded cats in the presence or absence of heart failure. No alterations were observed in long-chain fatty acyl CoA levels in either ventricle of PA-banded cats. In addition, a 20% reduction in total CoA was also observed in hypertrophied hearts of rats subjected to aortic banding. Although the CoA content was reduced in hypertrophied cat hearts, myocardial tissue levels of its precursor, pantothenic acid, were unaltered. Total tissue carnitine and long-chain fatty acyl-carnitine levels were unchanged in both ventricles of PA-banded cats; however, total carnitine was reduced by 25% in hypertrophied rat hearts. This study establishes a marked reduction in myocardial CoA content in pressure-overload hypertrophy.
52 citations
TL;DR: The rate of disappearance of endogenous lipids, calculated from gravimetric data, closely resembled the rate of oxidation of absorbed palmitate-U-14C throughout development, and both the presence and the function of the enzymes of β-oxidation in developing eggs ofscaris lumbricoides was established.
52 citations
TL;DR: Observations that single large additions of palmitoyl CoA reverse the nucleotide-induced inhibition of swelling in KC1 plus vahnomycin and partially overcome respiratory control have been advanced as evidence for acyl CoA, rather than the free acid, as the physiological modulator of C,H’.
51 citations