Topic
Acyl-CoA
About: Acyl-CoA is a research topic. Over the lifetime, 527 publications have been published within this topic receiving 25134 citations. The topic is also known as: Acyl Coenzyme A.
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TL;DR: The data show that in hepatocytes isolated from rats 24 h after administration of a single dose of TTA, there is a diversion of hepatic acyl-CoA from synthesis of triacylglycerols into beta-oxidation in the mitochondria.
28 citations
TL;DR: The objective was to develop a method to measure fatty acyl-CoA species that are present in tissues of mice with fatty acid oxidation defects using flow-injection tandem mass spectrometry and validate the method using liver of the short-chain-acyl- CoA dehydrogenase (SCAD) knock-out mice.
28 citations
TL;DR: Characteristics ofSerine palmitoyltransferase explain the predominance of long-chain bases with 18 carbon atoms in brain sphingolipids, and account for the minor variants such as the C17- and C20-long chain bases.
28 citations
TL;DR: There is now evidence to implicate acyl-CoA esters in the regulation of a variety of biological processes, ranging from mitochondrial metabolism to gene transcription to insulin secretion and signaling.
Abstract: Fatty acyl-CoA esters have the ability to bind at specific sites on certain proteins through their CoA moiety, thereby acting as modulators of cellular metabolism. In some cases at least, the acyl-CoA competes with cofactors (nucleotides) for binding to the proteins and results in either their activation or inhibition of catalytic activity. Photolabeling derivatives of acyl-CoA permit covalent binding of the esters to the proteins, which should lead to determination of amino acid residues required for ligand binding, if a common binding motif exists. On the basis of the accumulation of published results, there is now evidence to implicate acyl-CoA esters in the regulation of a variety of biological processes, ranging from mitochondrial metabolism to gene transcription to insulin secretion and signaling.
27 citations
TL;DR: The results suggest that peroxisomal β-oxidation plays an important role in the biosynthesis of functional lipids such as phospholipids, in addition to bile acids and cholesterol (previous report) by supplying acetyl-CoA.
27 citations