Topic
Acyl-CoA
About: Acyl-CoA is a research topic. Over the lifetime, 527 publications have been published within this topic receiving 25134 citations. The topic is also known as: Acyl Coenzyme A.
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TL;DR: Interestingly, oleoyl-CoA presents a markedly different transfer behavior compared to the rest of the ligands tested, probably indicating the possibility of specific targeting of ligands to different metabolic fates.
16 citations
TL;DR: Findings support the view that the metabolite is directly implicated in the cytotoxic action and proportionality between the degree of cellular cytotoxicity and metabolite levels is revealed.
16 citations
TL;DR: A mutation of Bacillus subtilis (bfmB) is analyzed that results in an acyl-CoA:acyl-carrier-protein transacylase with low affinity for branched acyl -CoA substrates; it maps in the acf-hisH region of the chromosome.
Abstract: We have analyzed a mutation of Bacillus subtilis (bfmB) that results in an acyl-CoA:acyl-carrier-protein transacylase with low affinity for branched acyl-CoA substrates; it maps in the acf-hisH region of the chromosome. The aceA mutation, present in the parent of the bfmB mutant, causes a deficiency in pyruvate dehydrogenase and maps in the pycA-pyrA region. Strains carrying the bfmB mutation synthesize branched-chain fatty acids at a rate sufficient for normal growth only if branched acyl-CoA precursors are present in the medium. They grow well if the medium is supplemented with 0.1 mM 2-methylbutyrate, isobutyrate or isovalerate, or with 1.0 mM isoleucine or Jaline; leucine does not support growth. Growth supported by valine and isoleucine is inhibited by butyrate and other straight short-chain fatty acids at concentrations (0.1 mM) which do not inhibit growth of the standard strain; the inhibition is prevented by short branched fatty acids which are converted to long-chain fatty acids appearing as major constituents in membrane lipids. Other results suggest that the acyl-CoA:acyl-carrier-protein transacylase activity of B. subtilis is controlled by separate enzymatic sites for the acyl-CoA precursors of branched and straight chain fatty acids. Whether these sites are contained in one or two enzymes is not known.
16 citations
TL;DR: Long-chain acyl CoA may be an important intermediate for matching triglyceride hydrolysis with the supply of extracellular fatty acids and the rates of fatty acid oxidation.
16 citations
TL;DR: Those tissues that contained high levels of docosahexaenoic acid also had the highest activation capacity for this fatty acid, except for liver, which was activated much less actively in heart tissue than the other fatty acids.
Abstract: The conversion of labeled palmitic, linoleic, arachidonic and docosahexaenoic acids to their respective acyl CoA's was studied in homogenates and microsomes of rat tissues. The highest activity, both in homogenates and microsomes, was seen in liver and heart. There was moderate activity in retina, brain, lung, kidney and testes and the lowest activity was found in spleen. Docosahexaenoic acid was activated much less actively in heart tissue than the other fatty acids. In all tissues examined, the highest activation was observed with arachidonic acid and the lowest with docosahexaenoic acid. Except for liver, those tissues that contained high levels of docosahexaenoic acid also had the highest activation capacity for this fatty acid.
16 citations