Topic
Acyl-CoA
About: Acyl-CoA is a research topic. Over the lifetime, 527 publications have been published within this topic receiving 25134 citations. The topic is also known as: Acyl Coenzyme A.
Papers published on a yearly basis
Papers
More filters
TL;DR: The data presented show that the addition of GLA to the diet of Walker 256 tumour-bearing rats can greatly decrease the rate of development of the tumours burden, due to the accumulation of poorly metabolised acyl CoA's within the tumour cell cytoplasm which, when coupled with altered mitochondrial composition, membrane potential and ultrastructure, may be a signal for cell death.
Abstract: Walker 256 tumour-bearing rats were fed pelleted chow containing low-gamma-linolenic acid (GLA) (2.98%) or high-GLA (5.55%) during the twelve-day period after subcutaneous implantation of the tumour. The presence of n-6, polyunsaturated GLA in the diet caused a concentration-dependent decrease in tumour growth, reaching an almost 50% reduction in final tumour weight in the high-GLA group. The eicosatrienoic acid content of the whole tumour homogenate and of the Percoll-purified mitochondrial fraction was increased by the GLA-rich diets. Changes in the fatty acid composition of the cytoplasmic acyl CoA pool were also found, with increases in GLA content in both the low- and high-GLA groups. Additionally, increases in eicosatrienoic acid and arachidonic acid were found in the high-GLA group. Both the cytoplasmic acyl CoA content and the mitochondrial acyl CoA synthetase activity were increased by GLA in the diet and lipid peroxidation was also increased as determined by an increase in TBARS content. Changes in mitochondrial fatty acid composition were accompanied by a decrease in the mitochondrial membrane potential in the high-GLA group. Tumours from the control and GLA groups were examined by transmission electron microscopy. This revealed an increase in mitochondrial area and volume in the high-GLA group, in comparison with the control group, as well as a change in general cell ultrastructure, with many cells found in an apoptotic state or in a necrotic state, possibly secondary to apoptosis. The data presented show that the addition of GLA to the diet of Walker 256 tumour-bearing rats can greatly decrease the rate of development of the tumour burden. This may be, in part, due to the accumulation of poorly metabolised acyl CoA's within the tumour cell cytoplasm which, when coupled with altered mitochondrial composition, membrane potential and ultrastructure, may be a signal for cell death.
12 citations
TL;DR: It is found that long‐chain fatty acids and their CoA ester derivatives inhibit CBR1, and a possible new food‐drug interaction through inhibition of CBR 1‐mediated intestinal first‐pass drug metabolism by dietary fatty acids is suggested.
12 citations
TL;DR: Results suggest that enrichment of arachidonic acid in the sn-2 position of phosphatidylinositol is established by the high specificity and affinity of 1-acyl-GPI acyltransferase for arachidonoyl-CoA.
12 citations
TL;DR: The greater capacity of neonatal membranes for acylation by the de novo pathway is in accord with the requirements for neonatal muscle to effect high rates of triacylglycerol and phospholipid synthesis essential for oxidative metabolism and membrane synthesis during postnatal development and growth.
12 citations
01 Jan 2016
TL;DR: The process of FA synthesis occurs in the cytosol, whereas the process of β-oxidation of FA takes place in the mitochondrial matrix as discussed by the authors, and the final products of FA βoxidation are acyl CoA, FADH 2, and NADH.
Abstract: Fatty acids (FAs) are long hydrocarbon chain molecules with a terminal carboxylate group, originating from the organism or food. Their nomenclature, structure, and properties depend on the length of hydrocarbon chain, degree of unsaturation, and position of double bond(s). The process of FA synthesis occurs in the cytosol, whereas the process of β-oxidation of FA takes place in the mitochondrial matrix. Saturated FAs are synthesized by the enzyme system FA synthase, while synthesis of unsaturated FA involves elongase and desaturase activity. The final products of FA β-oxidation are acyl CoA, FADH 2 , and NADH.
12 citations