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Ageratum conyzoides
About: Ageratum conyzoides is a research topic. Over the lifetime, 928 publications have been published within this topic receiving 13813 citations.
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TL;DR: Results from prothrombin timing showed that A. afriana was the most efficacious haemostatic plant followed by L. owariensis, and L. curcas the least.
Abstract: Leaves of Ageratum conyzoides (L), Alchornea cordifolia (Schym and Thonn) Muel. Arg, Aspilia africana (Pers.) C. D. Adams, Baphia nitida (Lodd), Chromolaena odorata (L) K. R., Landophia owariensis (P. Beauv) and sap of Jatropha curcas (L) used traditionally to arrest bleeding in fresh cuts were comparatively investigated phytochemically and their ability to precipitate and coagulate blood plasma. Saponins and tannins were the most abundant compounds in these plants while flavoids were the least. Crude aqueous extracts of alkaloids, flavonoids, tannins and saponins from these plants precipitated and coagulated blood plasma within time limits of 4 to 120 seconds (for precipitation) and 15 to 1500 seconds (for coagulation). Results from prothrombin timing showed that A. afriana was the most efficacious haemostatic plant followed by L. owariensis, and L. curcas the least. Some similarities in their chemical composition established a scientific basis for common usage in traditional medicine.
Key words: Phytochemical, crude extracts, haemostatic plants.
(Global Journal of Pure and Applied Sciences: 2002 8(2): 203-208)
976 citations
TL;DR: The results offer a scientific basis for the traditional use of water and ethanol extracts of A. wilkesiana, O. gratissimum, T. avicennioides and P. discoideus against MRSA-associated diseases, but B. ferruginea and A. conyzoides were ineffective in vitro in this study; it is suggested the immediate stoppage of their traditional use in Lagos, Nigeria.
Abstract: Six Nigerian medicinal plants Terminalia avicennioides, Phylantus discoideus, Bridella ferruginea, Ageratum conyzoides, Ocimum gratissimum and Acalypha wilkesiana used by traditional medical practitioners for the treatment of several ailments of microbial and non-microbial origins were investigated for in vitro anti-methicillin Resistant Staphylococcus aureus (MRSA) activity. Fresh plant materials were collected from the users. Water and ethanol extracts of the shredded plants were obtained by standard methods. The Bacterial cultures used were strains of MRSA isolated from patients. MRSA was determined by the reference broth microdilution methods using the established National Committee for Clinical Laboratory Standards break points. Staphylococcus aureus NCIB 8588 was used as a standard strain. Susceptibility testing and phytochemical screening of the plant extracts were performed by standard procedures. Controls were maintained for each test batch. Both water and ethanol extracts of T. avicennioides, P. discoideus, O. gratissimum, and A. wilkesiana were effective on MRSA. The Minimum Inhibition Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the ethanol extracts of these plants range from 18.2 to 24.0 mcg/ml and 30.4 to 37.0 mcg/ml respectively. In contrast, MIC range of 30.6 to 43.0 mcg/ml and 55.4 to 71.0 mcg/ml were recorded for ethanol and water extracts of B. ferruginea, and A. conyzoides respectively. Higher MBC values were obtained for the two plants. These concentrations were too high to be considered active in this study. All the four active plants contained at least trace amount of anthraquinones. Our results offer a scientific basis for the traditional use of water and ethanol extracts of A. wilkesiana, O. gratissimum, T. avicennioides and P. discoideus against MRSA-associated diseases. However, B. ferruginea and A. conyzoides were ineffective in vitro in this study; we therefore suggest the immediate stoppage of their traditional use against MRSA-associated diseases in Lagos, Nigeria.
468 citations
TL;DR: It is demonstrated that yellow vein disease of A. conyzoides results from co-infection by AYVV DNA A and a circular DNA that is approximately half its size that is designated DNA beta, which represents a satellite-like DNA.
Abstract: Ageratum conyzoides L., a weed species widely distributed throughout southeast Asia, frequently exhibits striking yellow vein symptoms associated with infection by Ageratum yellow vein virus (AYVV), a member of the Geminiviridae (genus Begomovirus). Most begomoviruses have bipartite genomes (DNAs A and B), but only a DNA A has been identified for AYVV. We demonstrate that yellow vein disease of A. conyzoides results from co-infection by AYVV DNA A (2,741 nt) and a circular DNA that is approximately half its size (1,347 nt) that we designate DNA beta. Apart from the sequence TAATATTAC, common to all geminiviruses and containing the initiation site of rolling circle replication, DNA beta shows negligible sequence homology either to AYVV DNA A or to DNA B associated with bipartite begomoviruses. DNA beta depends on DNA A for replication and is encapsidated by DNA A-encoded coat protein and so has characteristics of a DNA satellite. However, systemic infection of A. conyzoides by DNA A alone is sporadic and asymptomatic, and DNA A accumulation is reduced to 5% or less of its accumulation in the presence of DNA beta. Therefore, DNA A and DNA beta together form a previously unrecognized disease-inducing complex. Our data also demonstrate that the nanovirus-like DNA 1 component associated with infected A. conyzoides plays no essential role in the disease and represents a satellite-like DNA. Furthermore, the satellite DNA previously found associated with tomato leaf curl virus is probably a defective DNA beta homologue.
402 citations
TL;DR: The comprehensive account of the chemical constituents and the biological activities of Ageratum conyzoides L., are presented in this review such that the potential use of this plant either in pharmaceutics or as an agricultural resource can be evaluated.
275 citations
TL;DR: More than 90% wound healing was recorded in the extract and cicatrin powder treated groups by 14 days post surgery, where as 72% healing was observed in the distilled water-treated group, significantly different from those of extract and antibiotic-treated groups.
275 citations