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Showing papers on "Aging brain published in 1978"



Book
01 Nov 1978
TL;DR: The concept that aging is an endogenous process inherent in all living things and not basically dependent on stress and disease is increasingly accepted, although there are still not sufficient data to choose finally between these alternatives or to conclude that a cell, organ, or organism placed in an optimal environment may not live indefinitely.
Abstract: I * Introduction.- 1 The Ponce de Leon Trail Today.- II * Aging in Cells and their Molecules.- 2 Cell Aging: A Model System Approach.- 3 Is Limited Cell Proliferation the Clock That Times Aging?.- 4 Molecular Biology of Aging.- III * Aging in Plants and Lower Animals.- 5 Cellular and Metabolic Aspects of Senescence in Higher Plants.- 6 The Biological Significance of Death in Plants.- 7 Aging in Lower Animals.- IV * Aging in Humans and Other Mammals.- 8 Exercise and Aging.- 9 Diet and Nutrient Needs in Old Age.- 10 Nutritional Regulation of Longevity.- 11 Consequences of Alcohol and Other Drug Use in the Aged.- 12 Physical Changes of the Aging Brain.- 13 Aging and Immune function.- 14 Genes and Aging.- 15 The Dilemma of Aging Parents: Increased Risk of Genetically Abnormal Offspring.- V * Hormones and Aging.- 16 Endocrinology and Aging.- 17 Hormone "Replacement" in the Aged: Proceed with Care.- 18 Altered Biochemical Responsiveness and Hormone Receptor Changes during Aging.- 19 The Brain and Aging.- VI * Aging in Perspective.- 20 Evolutionary Biology of Senescence.- 21 The Origin, Evolution, Nature, and Causes of Aging.

18 citations


Book ChapterDOI
01 Jan 1978
TL;DR: Enhanced resistance conferred by drugs in hypoxia and related situations is of potential therapeutic predictive value and Sequential pharmacological studies are reported with several drugs, including nootropics, that are used in geropsychiatry.
Abstract: Impaired cerebral oxygen supply, of different organic and functional origins, is a usual concomitant of aging. Therefore enhanced resistance conferred by drugs in hypoxia and related situations is of potential therapeutic predictive value. Sequential pharmacological studies are reported with several drugs, including nootropics, that, among other indications, are used in geropsychiatry. The experiment models are: survival in mice to a nitrogen hypoxia and a curare-like short-acting agent; the same in bilateral carotid ligated rats and in unilateral ligated ones to subsequent nitrogen-hypoxia; EEG resistance and recovery after nitrogen-hypoxia as well as survival and EEG criteria after barbiturate intoxication in rabbits.

5 citations


Journal Article
TL;DR: The activity of carbonic anhydrase demonstrates in both human cortex and corpus striatum an age-dependent decrease which begins after the 6th decade of life, similar to morphological and physiological changes occuring in the aging brain.
Abstract: Little information about the possible neurochemical-enzymatic changes occuring during aging of human brain is available. We, therefore, investigated the activity of various enzymes of human brains obtained at autopsy and covering a range from 19 to 91 years. Protein kinase, which mediates the information carried by the second messenger cAMP, does not show age-related changes of basal activity. Cyclic AMP-dependent activation of protein kinase remains nearly constant up to 60 years of life, but undergoes a distinct and progressive decline between 60 and 90 years. In corpus striatum no age-related changes of cyclic AMP-dependent protein kinase activity were observed. The activity of carbonic anhydrase demonstrates in both human cortex and corpus striatum an age-dependent decrease which also begins after the 6th decade of life. These neurochemical changes are similar to morphological and physiological changes occuring in the aging brain. They begin after the 60th year of life.

3 citations