Topic
Aging brain
About: Aging brain is a research topic. Over the lifetime, 1255 publications have been published within this topic receiving 66405 citations.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Evidence implicating menopause-related declines in 17β-estradiol in cognitive aging and AD risk is implicated, highlighting an urgent need for better integration between neurology, psychiatry, and women’s health practices.
Abstract: Ovarian hormones, particularly 17β-estradiol, are involved in numerous neurophysiological and neurochemical processes, including those subserving cognitive function. Estradiol plays a key role in the neurobiology of aging, in part due to extensive interconnectivity of the neural and endocrine system. This aspect of aging is fundamental for women’s brains as all women experience a drop in circulating estradiol levels in midlife, after menopause. Given the importance of estradiol for brain function, it is not surprising that up to 80% of peri-menopausal and post-menopausal women report neurological symptoms including changes in thermoregulation (vasomotor symptoms), mood, sleep, and cognitive performance. Preclinical evidence for neuroprotective effects of 17β-estradiol also indicate associations between menopause, cognitive aging, and Alzheimer’s disease (AD), the most common cause of dementia affecting nearly twice more women than men. Brain imaging studies demonstrated that middle-aged women exhibit increased indicators of AD endophenotype as compared to men of the same age, with onset in perimenopause. Herein, we take a translational approach to illustrate the contribution of ovarian hormones in maintaining cognition in women, with evidence implicating menopause-related declines in 17β-estradiol in cognitive aging and AD risk. We will review research focused on the role of endogenous and exogenous estrogen exposure as a key underlying mechanism to neuropathological aging in women, with a focus on whether brain structure, function and neurochemistry respond to hormone treatment. While still in development, this research area offers a new sex-based perspective on brain aging and risk of AD, while also highlighting an urgent need for better integration between neurology, psychiatry, and women’s health practices.
10 citations
01 Jan 1994
10 citations
••
TL;DR: A positive T2-NS correlation in irradiated, ischemic rats that corresponded to late-stage brain recovery was found, and may provide a simple MRI-based criterion for recognition of regenerative brain transformation in aged patients following stroke.
10 citations
••
TL;DR: Histomorphometric analysis of age-related structural changes in the brain was performed in CW1 female mice, finding the thickness of the frontoparietal cortex (FPC), and the surface area of the dorsal hippocampus and the MH were found to decrease significantly from 9 to 24 months of age.
10 citations
••
TL;DR: Results indicate that alcohol's ability to inhibit NMDA-stimulated catecholamine release is not significantly altered with aging, and alcohol produced a concentration-dependent inhibition of overflow at all ages and brain regions tested.
10 citations